A sudden creatinine increase: A case report     

Bernhard Strasser  Sebastian Strasser  Josef Tomasits 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2022,32(1)

Creatinine and estimated glomerular filtration rate (eGFR) are first-line laboratory parameters in the diagnosis of various renal diseases. In recent decades, cystatin C (cysC) has furthered the laboratory repertoire regarding renal status assessment and has been implemented in many clinical guidelines. Accordingly, with the establishment of cysC as a renal routine biomarker, further opportunities for assessing eGFR have been attained. Nevertheless, various limitations are still associated with cysC and creatinine analysis. Preanalytical errors could cause false results in both biomarkers. In our case, we were confronted with implausibly elevated creatinine levels due to preanalytical errors.  相似文献   

Correlates of health in adolescent elite athletes and adolescents: A cross-sectional study of 1016 adolescents     

Philip von Rosen  Oskar Olofsson  Sebastian Väsbom  Annette Heijne 《European Journal of Sport Science》2019,19(5):707-716

The primary aim of this cross-sectional study was to compare subjective correlates of health, such as nutrition, self-esteem, sleep and stress, between adolescent elite athletes (n?=?625) and a reference group of adolescents (n?=?391) not involved in elite sports. A secondary aim was to study predictors for self-perceived stress. A questionnaire was e-mailed to all participants containing valid questions about competence-based self-esteem, nutrition, self-perceived stress and sleep. Our results show that adolescent elite athletes reported significantly (p?p?相似文献   

Geschlecht im Bildungsgang     

Nils Kaufmann  Sebastian Salomon 《Sportwissenschaft》2009,39(3):263-266

  相似文献   

IGF1–PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies,biomarkers, and predicting cardiotoxicity     

Sebastian Bass-Stringer  Celeste M.K. Tai  Julie R. McMullen 《运动与健康科学(英文)》2021,10(6):637

Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing health burden and a leading cause of death worldwide. To date, limited treatment options exist for the treatment of heart failure, but exercise has been well-established as one of the few safe and effective interventions, leading to improved outcomes in patients. However, a lack of patient adherence remains a significant barrier in the implementation of exercise-based therapy for the treatment of heart failure. The insulin-like growth factor 1 (IGF1)–phosphoinositide 3-kinase (PI3K) pathway has been recognized as perhaps the most critical pathway for mediating exercised-induced heart growth and protection. Here, we discuss how modulating activity of the IGF1–PI3K pathway may be a valuable approach for the development of therapies that mimic the protective effects of exercise on the heart. We outline some of the promising approaches being investigated that utilize PI3K-based therapy for the treatment of heart failure. We discuss the implications for cardiac pathology and cardiotoxicity that arise in a setting of reduced PI3K activity. Finally, we discuss the use of animal models of cardiac health and disease, and genetic mice with increased or decreased cardiac PI3K activity for the discovery of novel drug targets and biomarkers of cardiovascular disease.  相似文献   

Sportvereinsforschung in Deutschland     

Jürgen Baur  Sebastian Braun 《Sportwissenschaft》2001,31(2):199-212

  相似文献   

Teachers’ professional knowledge and noticing: The case of multiple representations in the mathematics classroom     

Anika Dreher  Sebastian Kuntze 《Educational Studies in Mathematics》2015,88(1):89-114

  相似文献   

Measuring the (dis-)similarity between expert and novice behaviors as serious games analytics     

Christian Sebastian Loh  Yanyan Sheng 《Education and Information Technologies》2015,20(1):5-19

  相似文献   

The role of schools in bridging within-school achievement gaps based on socioeconomic status: a cross-national comparative study     

Haigen Huang  James Sebastian 《Compare》2015,45(4):501-525

Since the publication of the Coleman report in 1966, research on the role of schools in influencing student achievement relative to the role of family background has generated considerable interest and controversy. A large volume of international and comparative research has also been devoted to studying school effects on student achievement. Relatively few studies have examined international differences in the importance of schools in bridging achievement gaps based on socioeconomic status (SES). Using PISA 2012 data, this study examines the role of schools in bridging within-school SES gaps in achievement and compares findings across 61 countries. Contrary to prior research, we find that schools may have limited ability in bridging SES gaps that exist within schools. We also find that across all countries included in the study, specific factors such as the school’s learning environment and school context are not systematically associated with within-school SES gaps.  相似文献   

Automated vehicles and the morality of post-collision behavior     

Krügel  Sebastian  Uhl  Matthias  Balcombe  Bryn 《Ethics and Information Technology》2021,23(4):691-701

Ethics and Information Technology - We address the considerations of the European Commission Expert Group on the ethics of connected and automated vehicles regarding data provision in the event of...  相似文献   

The diminishing signaling value of patents between early rounds of venture capital financing     

Sebastian Hoenen  Christos Kolympiris  Wilfred Schoenmakers  Nicholas Kalaitzandonakes 《Research Policy》2014

A long stream of research has documented the positive effects that patents bring about to emerging firms in high technology industries. The general consensus is that patents contribute to firm growth because they confer monopolistic market rights, offer protection from competitors, increase the negotiating position of patent holders and other benefits. What has received relatively less attention in the literature is whether patents act as a signal that attracts investors such as venture capital firms. The handful of studies that have addressed that question has not analyzed whether the signaling function of patents decreases after the initial attraction of venture capital, as information asymmetries between investors and target firms reduce. In this study we hypothesize that patent activity has a signaling value that diminishes once information asymmetries between investors and funded firms lessen. To study our proposition we draw upon a longitudinal dataset of more than 580 U.S.-based biotechnology firms to empirically demonstrate that biotechnology firms that have submitted patent applications substantially increase the level of funding they receive for their first round of financing. In line with a reduction of information asymmetries once the initial investment has materialized, patent applications and granted patents have no effect on the growth of venture capital funds raised during the second round of financing. We conclude the study with a discussion of avenues for new research, implications for policy makers that consider the usefulness of the current patent system and with insights that can be employed by managers of firms in knowledge intensive areas such as biotechnology.  相似文献