Robust fluidic connections to freestanding microfluidic hydrogels     

Shannon L. Faley  Bradly B. Baer  Taylor S. H. Larsen  Leon M. Bellan 《Biomicrofluidics》2015,9(3)

Biomimetic scaffolds approaching physiological scale, whose size and large cellular load far exceed the limits of diffusion, require incorporation of a fluidic means to achieve adequate nutrient/metabolite exchange. This need has driven the extension of microfluidic technologies into the area of biomaterials. While construction of perfusable scaffolds is essentially a problem of microfluidic device fabrication, functional implementation of free-standing, thick-tissue constructs depends upon successful integration of external pumping mechanisms through optimized connective assemblies. However, a critical analysis to identify optimal materials/assembly components for hydrogel substrates has received little focus to date. This investigation addresses this issue directly by evaluating the efficacy of a range of adhesive and mechanical fluidic connection methods to gelatin hydrogel constructs based upon both mechanical property analysis and cell compatibility. Results identify a novel bioadhesive, comprised of two enzymatically modified gelatin compounds, for connecting tubing to hydrogel constructs that is both structurally robust and non-cytotoxic. Furthermore, outcomes from this study provide clear evidence that fluidic interconnect success varies with substrate composition (specifically hydrogel versus polydimethylsiloxane), highlighting not only the importance of selecting the appropriately tailored components for fluidic hydrogel systems but also that of encouraging ongoing, targeted exploration of this issue. The optimization of such interconnect systems will ultimately promote exciting scientific and therapeutic developments provided by microfluidic, cell-laden scaffolds.  相似文献   

Interactive Kiosk at the Texas Tech University Libraries     

Ryan Litsey  Susan Hidalgo  Kaley Daniel  Julie Barnett  Amy Kim  Shannon Jones 《Journal Of Access Services》2015,12(1-2):31-41

The academic library, given its often privileged position on campus, is the information source that can include directional as well as general campus facts among the myriad of print and e-resources for reference. Also, an academic library's audiences can be quite varied and include prospective students or parents seeking more general knowledge of the building and the campus. Many times this need for information drives patrons to the library service desks. Sometimes, especially during the high-demand seasons of new student orientation and beginning of the fall semesters, the desk is so busy that many patrons will leave because they don't have the time to wait. To address this immediate need for information, Texas Tech University Libraries developed an interactive kiosk to provide general information for frequently asked questions in a more efficient, creative, and interactive way. The kiosk provides a fun method of satisfying a patron's information needs without the requirement of a staff member or the need to wait in line for help. The kiosk is available as long as the Library is open and provides a variety of useful answers to general questions, as well as facts about the Library.  相似文献   

Into the gray: a modified approach to citation analysis to better understand research impact     

Shannon L. Sibbald  Jennifer C. D. MacGregor  Marisa Surmacz  C. Nadine Wathen 《Journal of the Medical Library Association》2015,103(1):49-54

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Provision of consumer health information in Alberta's Rural Public Libraries   总被引：1，自引：0，他引：1  

Georges Danhoundo  Doug Whistance‐Smith  Daniel Lemoine  Jill Konkin 《Health information and libraries journal》2019,36(1):41-59

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It Costs a Lot to Look This Cheap: Preference for Low-Quality Graphic Design     

Shannon Zenner 《Visual Communication Quarterly》2019,26(1):22-31

Some 1,000 surveys were conducted on Amazon's MTurk, asking respondents to rate a high- and low-quality visual design, in this case a billboard ad. While most respondents preferred the high-quality ad, over a third opted for the low-quality design. Respondents who showed a preference for the low-quality design liked it for its “static” qualities, in that it was common, typical, average, and standard. Those who preferred the high-quality design liked it for its “dynamic” qualities, such that it was innovative, fascinating, novel, creative, and rich in elements. Older participants show a significant preference for the low-quality design. Implications of these findings for different types of visual communication are discussed.  相似文献   

Investigating the Development of the “Mobile Museum” from the Perspective of Service     

Chia‐Hui HUang  Fang‐Suey Lin 《Curator: The Museum Journal》2016,59(4):387-410

During economic development, modern museums face competition from various leisure activities and entertainment sites, and to achieve sustainable development, museums should reflect on providing high‐quality service to satisfy visitors’ expectations. Based on service design‐related theories, this research team conducted a case study to explore the planning, implementation, and meaning of Mobile Museums. It investigated design development from the perspective of public service design and summarized the policy, design, and service satisfaction results for Mobile Museums. Finally, the similarities in service processes are discussed between Mobile Museums and the general service industry. According to this study, attracting more visitors is the biggest issue facing museums today, as are the ways in which museums must actively provide service and become recognized to compete with others. This study identifies the onstage and backstage support of museums as well as their cultural features and non‐profit services.  相似文献   

Block Talk: Spatial Language During Block Play     

Katrina Ferrara  Kathy Hirsh‐Pasek  Nora S. Newcombe  Roberta Michnick Golinkoff  Wendy Shallcross Lam 《Mind, Brain, and Education》2011,5(3):143-151

Spatial skills are a central component of intellect and show marked individual differences. There is evidence that variations in the spatial language young children hear, which directs their attention to important aspects of the spatial environment, may be one of the mechanisms that contributes to these differences. To investigate how play affects variations in language, parents and children were assigned to 1 of 3 conditions: free play with blocks, guided play, or play with preassembled structures (Study 1). Parents in the guided play condition produced significantly higher proportions of spatial talk than parents in the other two conditions, and children in the guided play condition produced significantly more spatial talk than those in the free play condition. Study 2 established baselines of spatial language during activities not involving spatial materials. Proportions of spatial words were lower than those in any of the conditions of Experiment 1. In sum, interaction with blocks naturally elicits elevated levels of spatial language, especially in the context of guided play, suggesting simple‐to‐execute educational interventions.  相似文献   

Modifications of Recognition Memory Processes in Preterm Children: An Event‐Related Potential Study          下载免费PDF全文

Kerstin H. Kipp  Axel Mecklinger  Nicole Brunnemann  Mohammed G. Shamdeen  Juliane Meng‐Hentschel  Ludwig Gortner 《Child development》2015,86(2):379-393

Prematurity may cause hippocampal compromise. Therefore, hippocampus‐dependent memory processes (recollection‐based retrieval) may be more impaired than hippocampus‐independent processes (familiarity‐based retrieval). The memory of 18 children born preterm with reduced hippocampal volumes, without neonatal complications (weeks of gestation < 34, weight < 1,600 g), and 15 controls (8–10 years) was tested using an item recognition task. While groups were equal in memory performance, dissociation was found: The event‐related potential (ERP) correlate of familiarity was intact in the preterm group, whereas the correlate of recollection was attenuated. A follow‐up experiment ruled out that this was due to general cognitive deficits. Furthermore, gestational age correlated with the ERP index of recollection. Thus, recognition memory in preterm children may be characterized by a compensation of attenuated recollection by familiarity.  相似文献   

Easy as ABCABC: Abstract Language Facilitates Performance on a Concrete Patterning Task          下载免费PDF全文

Emily R. Fyfe  Nicole M. McNeil  Bethany Rittle‐Johnson 《Child development》2015,86(3):927-935

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Infant Attachment Security and Early Childhood Behavioral Inhibition Interact to Predict Adolescent Social Anxiety Symptoms          下载免费PDF全文

Erin Lewis‐Morrarty  Kathryn A. Degnan  Andrea Chronis‐Tuscano  Daniel S. Pine  Heather A. Henderson  Nathan A. Fox 《Child development》2015,86(2):598-613

Insecure attachment and behavioral inhibition (BI) increase risk for internalizing problems, but few longitudinal studies have examined their interaction in predicting adolescent anxiety. This study included 165 adolescents (ages 14–17 years) selected based on their reactivity to novelty at 4 months. Infant attachment was assessed with the Strange Situation. Multimethod BI assessments were conducted across childhood. Adolescents and their parents independently reported on anxiety. The interaction of attachment and BI significantly predicted adolescent anxiety symptoms, such that BI and anxiety were only associated among adolescents with histories of insecure attachment. Exploratory analyses revealed that this effect was driven by insecure‐resistant attachment and that the association between BI and social anxiety was significant only for insecure males. Clinical implications are discussed.  相似文献