排序方式： 共有114条查询结果，搜索用时 859 毫秒
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Manjima Dhar Jessica Wong Armin Karimi James Che Corinne Renier Melissa Matsumoto Melanie Triboulet Edward B. Garon Jonathan W. Goldman Matthew B. Rettig Stefanie S. Jeffrey Rajan P. Kulkarni Elodie Sollier Dino Di Carlo 《Biomicrofluidics》2015,9(6)
Circulating tumor cells (CTCs) are important biomarkers for monitoring tumor dynamics and efficacy of cancer therapy. Several technologies have been demonstrated to isolate CTCs with high efficiency but achieve a low purity from a large background of blood cells. We have previously shown the ability to enrich CTCs with high purity from large volumes of blood through selective capture in microvortices using the Vortex Chip. The device consists of a narrow channel followed by a series of expansion regions called reservoirs. Fast flow in the narrow entry channel gives rise to inertial forces, which direct larger cells into trapping vortices in the reservoirs where they remain circulating in orbits. By studying the entry and stability of particles following entry into reservoirs, we discover that channel cross sectional area plays an important role in controlling the size of trapped particles, not just the orbital trajectories. Using these design modifications, we demonstrate a new device that is able to capture a wider size range of CTCs from clinical samples, uncovering further heterogeneity. This simple biophysical method opens doors for a range of downstream interventions, including genetic analysis, cell culture, and ultimately personalized cancer therapy. 相似文献
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Stefanie Stadler 《High Ability Studies》1991,1(1):33-41
Results from a developmental study on pitch matching ability (PMA) were used to draw conclusions on diagnostic and educational practice in music. Forty children from 3 age groups (4, 6, 8 years) participated in a cross‐sectional study with repeated measurements. The factor age was not important in the development of vocal PMA, whereas timbre of note presentation had strong effects on reproduction: Children in all age groups were more successful with vocal than with instrumental presentation. Remarkable were the large individual differences: There are 4‐year‐old children who hare higher ability than many 8‐year‐olds. Evidence is presented that actively produced music gives more valid insights into the individual's competence than the perceptually and verbally dominated traditional procedures for assessing PMA. Emphasis is thus placed on vocal activities because they are the earliest musical (and/or prosodic) expressions. 相似文献
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Trinh Nguyen Hanna Schleihauf Melanie Kungl Ezgi Kayhan Stefanie Hoehl Pascal Vrtička 《Child development》2021,92(4):e565-e580
Interpersonal neural synchrony (INS) has been previously evidenced in mother–child interactions, yet findings concerning father–child interaction are wanting. The current experiment examined whether fathers and their 5- to 6-year-old children (N = 66) synchronize their brain activity during a naturalistic interaction, and addressed paternal and child factors related to INS. Compared to individual problem solving and rest, father–child dyads showed increased INS in bilateral dorsolateral prefrontal cortex and left temporo-parietal junction during cooperative problem solving. Furthermore, the father’s attitude toward his role as a parent was positively related to INS during the cooperation condition. These results highlight the implication of the father’s attitude to parenting in INS processes for the first time. 相似文献
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Reflection on events at work, including errors is often as a means to learn effectively through work. In a cross-sectional
field study in the banking sector, we investigated attitudes towards workplace errors (i.e. error orientation) as predictors
of reflective activity. We assumed the organisational climate for psychological safety to have a mediating effect. The study
participants were 84 client advisors from the retail banking departments in branches of a German bank. The client advisors’
were being affected by a range of changes in their workplaces at the time of the data collection. This situation afforded
these workers opportunity for learning but also involved the risk of error by these staff. Regression analyses identified
that error competence and learning from errors were significant predictors of reflection. The results confirmed the mediating
role of psychological safety on the association between attitudes towards errors and reflective working behaviour. 相似文献
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Stefanie Xinyi Chong Chien-Sing Lee 《Educational technology research and development : ETR & D》2012,60(4):639-657
There are many evidences of motivational and educational benefits from the use of learning software. However, there is a lack of study with regards to the teaching of creative writing. This paper aims to bridge the following gaps: first, the need for a proper framework for scaffolding creative writing through learning software; second, the lack of technical scaffolding in creative writing learning software; third, the need for customizable learning software that requires little programming knowledge; and fourth, personalized learning. To develop our initial framework, Merrill??s First Principles of Instruction is used as pedagogical scaffold and story setting, characters and story structure as component-based technical scaffolds. These were tested in a low-fidelity prototype. User testing indicates an increase in creativity, improvement in story development, clarity of ideas and language skills. We also derive two design principles, i.e. identity and interactivity. Based on these findings, a high-fidelity prototype, named Storyworld, is developed. T-test analyses on results indicate significant improvement in overall creative writing skills, as well as grammar, structure and creativity. The prototype utilizes component-based design in the technical scaffolds, which is encapsulated in a tidy framework that can be personalized for individual learning needs. Our most important contribution is a proper framework combining technical scaffolds and pedagogical scaffolds that not only makes learning more effective and motivating for students, but is also cost-effective in redesigning and personalizing lessons and systems. 相似文献
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Patricia K. Falk Elizabeth Hertenstein Stefanie Dennis Hunker 《Cataloging & classification quarterly》2013,51(1-3):214-223
Recent changes have forced Bowling Green State University (BGSU) to reevaluate our documentation, workflows, and communication. There have been staff retirements, changes in staff responsibilities, and a new faculty cataloger. Additionally, BGSU is implementing a discovery layer, purchasing shelf-ready books, and adding more electronic resources. It has become apparent that documentation needs to be updated and, in many cases, created from scratch. Collaboration is critical as catalogers are currently few in number and are seeing the need to work with other departments in ways unheard of previously. The creation of a new cataloging manual is vital to the success of cataloging at BGSU. 相似文献