Deleterious effects of obesity on physical fitness in pre-pubertal children     

Arianna Ceschia  Stefano Giacomini  Simone Santarossa  Miriam Rugo  Desy Salvadego  Alessandro Da Ponte 《European Journal of Sport Science》2016,16(2):271-278

The prevalence of obesity in children has increased dramatically during the past decades in Europe and understanding physical fitness and its components in children is critical to design and implement effective interventions. The objective of the present study was to analyse the association between physical fitness (aerobic, speed, agility, power, flexibility and balance) and body mass index (BMI) in pre-pubertal children. A total of 2411 healthy schoolchildren (7–11 years) participated in this study. Anthropometric characteristics and body composition were assessed by skinfold thickness. Physical fitness was measured by nine physical fitness tests: endurance running, 20 m running speed, agility, handgrip strength, standing long jump and squat jump, sit and reach, medicine ball forward throw and static balance. No relevant differences were observed between boys and girls regarding anthropometric characteristics, body composition and physical fitness. However, overweight and obese children showed significantly lower physical fitness levels in endurance running, speed and agility (mean: +18.8, +5.5 and +14.5% of time to complete tasks, respectively), lower limb power normalised to body mass (?23.3%) and balance tests (number of falls: +165.5%) than their normal weight counterparts. On the other hand, obesity did not affect handgrip, throwing and flexibility. In conclusion, increased BMI was associated with lower performance capabilities limiting proper motor skill development, which directly affects the ability of children to take on sports skills. Actions undertaken to promote children's wellness and fitness should be prioritised and introduced early in life with the aim of enhancing physical fitness as well as preventing overweight and obesity.  相似文献   

Study of the deterioration products,gilding, and polychromy of the stones of the Scuola Grande Di San Marco's façade in Venice     

Fabrizio Antonelli  Lorenzo Lazzarini  Stefano Cancelliere  Elena Tesser 《文物保护研究》2016,61(2):74-85

The Scuola Grande di San Marco is one of the most outstanding Renaissance buildings in Venice. Destroyed by fire in 1485, the Scuola was reconstructed between 1487 and 1495 by Pietro Lombardi (and sons), together with Giovanni Buora and Mauro Codussi. The façade is considered one of the finest and most original exteriors of Venetian buildings and in particular features refined sculptural and painted decorations and a remarkable pictorial effect created by the extensive use of polychrome marbles and the false perspective view between the pilasters of the lower order. Most of the stone materials (Istrian and Verona red limestones, nero di Roveré, pavonazzetto toscano, Carrara marble and various reused antique marbles) present evident decay phenomena such as scaling, exfoliation, powdering, fissuring, salt efflorescence, black crusts, and artificial patinas of various kinds. The present study reports the results of petrographic and chemical laboratory analyses carried out in preparation for the conservation treatment of the building, in order to characterize the main micro- and macro-morphologies of decay and to identify the causes and mechanisms of deterioration as well as the nature and application technique of the polychromy, gilding, and patinas present on parts of the monumental Renaissance façade.  相似文献   

Retrospective cytological evaluation of indeterminate thyroid nodules according to the British Thyroid Association 2014 classification and comparison of clinical evaluation and outcomes     

Massimo Giusti  Barbara Massa  Margherita Balestra  Paola Calamaro  Stefano Gay  Simone Schiaffino  Giovanni Turtulici  Simonetta Zupo  Eleonora Monti  Gianluca Ansaldo 《Journal of Zhejiang University. Science. B》2017,18(7):555-566

The cytology of 130 indeterminate nodules (Thy 3) was retrospectively reviewed according to the British Thyroid Association 2014 classification. Nodules were divided into Thy 3a (atypical features) and Thy 3f (follicular lesion) categories. Histology was available as a reference for 97 nodules. Pre-surgical evaluations comprised biochemical tests, color-Doppler ultrasonography (US), semi-quantitative elastography-US (USE), contrast-enhanced US (CEUS), and mutation analysis from cytological slides. Thyroid malignancy was the final diagnosis for 19% of surgically-treated nodules. No statistically significant difference in the risk of malignancy was found between Thy 3a (26%) and Thy 3f (14%) nodules. Histology of the Thy 3a and Thy 3f nodules showed a higher incidence of Hurtle cell adenomas in Thy 3f (29%) than in Thy 3a (3%) nodules (P=0.01). The only pre-surgical difference concerned the BRAF V600E mutation, which was positive in some Thy 3a but not in any Thy 3f nodules (P=0.04). Receiver-operating characteristic (ROC) analysis was used to obtain cut-off values from US (score), USE (ELX 2/1 strain index), and CEUS (time-topeak index and peak index) data. The cut-off values were similar for Thy 3a and Thy 3f nodules. Data showed that malignancy can be suspected if the US score is >2, ELX 1/2 strain index >1, time-to-peak index >1, and peak index <1. In a sub-group of 24 revised nodules (12 Thy 3a and 12 Thy 3f) with histology as a reference, the diagnostic power of cumulative pre-surgical analysis by means of US, USE, and CEUS showed high positive and negative predictive values (83% and 100%, respectively) for the presence of malignancy in Thy 3a and Thy 3f nodules. In conclusion, in our series of revised Thy 3 nodules, malignancy was low and displayed no significant differences between Thy 3a and Thy 3f categories. The use of cut-offs based on histology as a reference could reduce surgery. Our data support the conviction that, in mutation-negative Thy 3a and Thy 3f nodules, observation should be the first choice when not all instrumental results are suspect.  相似文献   

Using crowdsourcing for TREC relevance assessment     

Omar Alonso  Stefano Mizzaro 《Information processing & management》2012

Crowdsourcing has recently gained a lot of attention as a tool for conducting different kinds of relevance evaluations. At a very high level, crowdsourcing describes outsourcing of tasks to a large group of people instead of assigning such tasks to an in-house employee. This crowdsourcing approach makes possible to conduct information retrieval experiments extremely fast, with good results at a low cost.  相似文献   

Preventive thermographic diagnosis of historical buildings for consolidation     

Domenica Paoletti  Dario Ambrosini  Stefano Sfarra  Fabio Bisegna 《Journal of Cultural Heritage》2013,14(2):116-121

Conserving architectural heritage usually requires a multidisciplinary approach involving a variety of professionals and organizations. Since the evaluation of the state of conservation of historical buildings using destructive techniques should be avoided to prevent the integrity of the cultural heritage, the development of non-destructive and non-contact techniques is very important. InfraRed (IR) thermography is a non-destructive powerful tool for fast and accurate building diagnostics. In the investigation of historical structures, where a restoration or conservation treatment can cause irreversible damage to the structure, it is considered to be of most importance. A campaign of thermographic surveys were conducted on a large part of the historical cultural heritage of L’Aquila and its surroundings. In this paper we present the results of the study for the Church of Santa Maria ad Cryptas (XIII century), one of the most ancient buildings in the surroundings of L’Aquila and one of the best examples of Gothic art in Abruzzo, with the aim to evaluate the correspondence between the damage induced by the earthquake and the previous thermographic results, in order to validate the effectiveness of thermography and its role in preventive diagnosis.  相似文献   

Gene regulatory network stabilized by pervasive weak repressions: microRNA functions revealed by the May–Wigner theory     

Yuxin Chen  Yang Shen  Pei Lin  Ding Tong  Yixin Zhao  Stefano Allesina  Xu Shen  Chung-I Wu 《国家科学评论(英文版)》2019,6(6):1176

Food web and gene regulatory networks (GRNs) are large biological networks, both of which can be analyzed using the May–Wigner theory. According to the theory, networks as large as mammalian GRNs would require dedicated gene products for stabilization. We propose that microRNAs (miRNAs) are those products. More than 30% of genes are repressed by miRNAs, but most repressions are too weak to have a phenotypic consequence. The theory shows that (i) weak repressions cumulatively enhance the stability of GRNs, and (ii) broad and weak repressions confer greater stability than a few strong ones. Hence, the diffuse actions of miRNAs in mammalian cells appear to function mainly in stabilizing GRNs. The postulated link between mRNA repression and GRN stability can be seen in a different light in yeast, which do not have miRNAs. Yeast cells rely on non-specific RNA nucleases to strongly degrade mRNAs for GRN stability. The strategy is suited to GRNs of small and rapidly dividing yeast cells, but not the larger mammalian cells. In conclusion, the May–Wigner theory, supplanting the analysis of small motifs, provides a mathematical solution to GRN stability, thus linking miRNAs explicitly to ‘developmental canalization’.  相似文献   

Metabolic optimisation of the basketball free throw     

Johnny Padulo  Giuseppe Attene  Gian Mario Migliaccio  Francesco Cuzzolin  Stefano Vando 《Journal of sports sciences》2015,33(14):1454-1458

The free throw (FT) is a fundamental basketball skill used frequently during a match. Most of actual play occurs at about 85% of maximum heart rate (HR). Metabolic intensity, through fatigue, may influence a technically skilled move as the FT is. Twenty-eight under 17 basketball players were studied while shooting FTs on a regular indoor basketball court. We investigated FT accuracy in young male basketball players shooting at three different HRs: at rest, at 50% and at 80% of maximum experimentally obtained HR value. We found no significant FT percentage difference between rest and 50% of the maximum HR (FT percentage about 80%; P > 0.05). Differently, at 80% of the maximum HR the FT percentage decreased significantly by more than 20% (P < 0.001) down to about 60%. No preliminary warm-up is needed before entering game for the FT accuracy. Furthermore, we speculate that time-consuming, cooling-off routines usually performed by shooters before each FT may be functional to improve its accuracy.  相似文献   

The new institutional governance of Italian state universities: what role for the new governing bodies?     

Donina  Davide  Meoli  Michele  Paleari  Stefano 《Tertiary Education and Management》2015,21(1):16-28

Tertiary Education and Management - In 2010, a comprehensive reform required Italian state universities to restructure their institutional governance by revising their statutes. This interpretative...  相似文献   

Corrigendum to “Higher Education Policy: Why hope for Quality when rewarding Quantity?” [Research Policy Volume 49, Issue 8(2020) /104083]     

Alice Civera  Erik E. Lehmann  Stefano Paleari  Sarah A.E. Stockinger 《Research Policy》2021,50(2):104168

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Factors Affecting Students' Acceptance of Tablet PCs: A Study in Italian High Schools     

Stefano Cacciamani  Daniela Villani  Andrea Bonanomi  Claudia Carissoli  Maria Giulia Olivari  Laura Morganti 《Journal of Research on Technology in Education》2018,50(2):120-133

To maximize the advantages of the tablet personal computer (TPC) at school, this technology needs to be accepted by students as new tool for learning. With reference to the Technology Acceptance Model and the Unified Theory of Acceptance and Use of Technology, the aims of this study were (a) to analyze factors influencing high school students' acceptance of TPCs and (b) to detect any difference in this influence considering the frequency of TPC use, students' gender, and school grade. Two hundred and ninety-six students from six high schools in the Milan area participated in the study. Data were collected using an online survey. The results showed that empowerment in learning, perceived usefulness, and support conditions affect learning use, and empowerment in learning and affect influence communicative use of TPCs. The implications of these results are discussed. (Keywords: tablets, acceptance, digital technologies, high school, path analysis)  相似文献