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81.
82.
AbstractA key element contributing to deteriorating exercise capacity during physically demanding sport appears to be reduced carbohydrate availability coupled with an inability to effectively utilize alternative lipid fuel sources. Paradoxically, cognitive and physical decline associated with glycogen depletion occurs in the presence of an over-abundance of fuel stored as body fat that the athlete is apparently unable to access effectively. Current fuelling tactics that emphasize high-carbohydrate intakes before and during exercise inhibit fat utilization. The most efficient approach to accelerate the body’s ability to oxidize fat is to lower dietary carbohydrate intake to a level that results in nutritional ketosis (i.e., circulating ketone levels >0.5 mmol/L) while increasing fat intake for a period of several weeks. The coordinated set of metabolic adaptations that ensures proper interorgan fuel supply in the face of low-carbohydrate availability is referred to as keto-adaptation. Beyond simply providing a stable source of fuel for the brain, the major circulating ketone body, beta-hydroxybutyrate, has recently been shown to act as a signalling molecule capable of altering gene expression, eliciting complementary effects of keto-adaptation that could extend human physical and mental performance beyond current expectation. In this paper, we review these new findings and propose that the shift to fatty acids and ketones as primary fuels when dietary carbohydrate is restricted could be of benefit for some athletes. 相似文献
83.
The tablet computer offers options for streaming TV programming that potentially alters viewing behaviors compared to the traditional television set, yet there is a dearth of research related to this viewing alternative. This study uses a national sample of adult iPad owners to investigate the tablet's role as a TV. The frameworks of continuity-discontinuity, use-diffusion, and attention and absorption to programming are applied to uncover where the tablet fits into the current repertoire of viewing devices, and how individuals are engaging with traditional TV programming through it. Results show that overall, the tablet's functionality as a TV can lead to experiential differences. 相似文献
84.
Stephen Buck 《期刊图书馆员》2015,68(1-4):106-116
The article will outline the Core Competencies for Electronic Resources Librarians (NASIG Core Competencies Task Force [July 2013]) and intersect them with the practical everyday working experiences of an e-resources and periodicals librarian. The aim of the article is to convey an understanding of working in a practical library office environment, while being aware of the complexity of the theoretical competencies that are desirable and recommended. While it is aimed mainly at librarians, it should also be of interest to publishers and other vendors as they gain an understanding of what it is that librarians (their customers) do all day. 相似文献
85.
Christopher R. Phaneuf Nikita Pak D. Curtis Saunders Gregory L. Holst Joav Birjiniuk Nikita Nagpal Stephen Culpepper Emily Popler Andi L. Shane Robert Jerris Craig R. Forest 《Biomicrofluidics》2015,9(4)
Amplification of multiple unique genetic targets using the polymerase chain reaction (PCR) is commonly required in molecular biology laboratories. Such reactions are typically performed either serially or by multiplex PCR. Serial reactions are time consuming, and multiplex PCR, while powerful and widely used, can be prone to amplification bias, PCR drift, and primer-primer interactions. We present a new thermocycling method, termed thermal multiplexing, in which a single heat source is uniformly distributed and selectively modulated for independent temperature control of an array of PCR reactions. Thermal multiplexing allows amplification of multiple targets simultaneously—each reaction segregated and performed at optimal conditions. We demonstrate the method using a microfluidic system consisting of an infrared laser thermocycler, a polymer microchip featuring 1 μl, oil-encapsulated reactions, and closed-loop pulse-width modulation control. Heat transfer modeling is used to characterize thermal performance limitations of the system. We validate the model and perform two reactions simultaneously with widely varying annealing temperatures (48 °C and 68 °C), demonstrating excellent amplification. In addition, to demonstrate microfluidic infrared PCR using clinical specimens, we successfully amplified and detected both influenza A and B from human nasopharyngeal swabs. Thermal multiplexing is scalable and applicable to challenges such as pathogen detection where patients presenting non-specific symptoms need to be efficiently screened across a viral or bacterial panel. 相似文献
86.
Paul T. Cutrufello Stephen J. Gadomski Gerald S. Zavorsky 《Journal of sports sciences》2015,33(14):1459-1466
Citrulline has been proposed as an ergogenic aid, leading to an interest in watermelon given its high citrulline concentration. The aim of this study was to determine the effects of a single, pre-exercise dose of l-citrulline, watermelon juice, or a placebo on the total maximum number of repetitions completed over 5 sets, time to exhaustion, maximal oxygen consumption (VO2max), anaerobic threshold, and flow-mediated vasodilation. A randomised double-blind within-participants study design was used to examine these effects among 22 participants (n = 11 males). Supplementation included either a 7.5% sucrose drink containing 6 g of l-citrulline, 710 mL of watermelon juice (~1.0 g citrulline), or a 7.5% sucrose placebo drink. Supplementation was administered 1 or 2 h before exercise testing to investigate a timing effect. There was no significant effect between the three supplements for the total number of repetitions, time to exhaustion, VO2max, anaerobic threshold, or flow-mediated vasodilation. There was also no interaction observed relative to gender or supplement timing (P > 0.05). A single dose of l-citrulline or watermelon juice as a pre-exercise supplement appears to be ineffective in improving exercise performance; however, greater doses of l-citrulline have been shown to be safe and are currently left unexamined. 相似文献
87.
题目:一种支持产品平台设计的多准则模块划分方法 总被引:2,自引:0,他引:2
目的:研究多准则约束下的产品模块划分方法,为企业建立稳健的模块化产品平台奠定基础。方法:采用改进的多目标进化算法对建立的多准则模块划分数学模型求解,并采用模糊集合评价机制进行最优解的寻取,得到基于多准则模块划分方法的产品模块划分结果。结论:通过改进的多目标进化算法求解多准则模块划分模型,能够得到有效支持产品平台设计的产品模块划分方案。通过与已有优化方法的比较验证了本文提出的多准则模块划分方法的优越性。 相似文献
88.
Kenneth Tobin Leonie Rennie Grady Venville Hye-Eun Chu Peter Fensham James Gallagher Reinders Duit Wolfgang Graeber Ed van den Berg Brian Hand Stephen Ritchie Justin Dillon 《Cultural Studies of Science Education》2011,6(3):783-793
For almost a half century David F. Treagust has been an exemplary science educator who has contributed through his dedication and commitments to students, curriculum development and collaboration with teachers, and cutting edge research in science education that has impacted the field globally, nationally and locally. A hallmark of his outstanding career is his collaborative style that inspires others to produce their best work. 相似文献
89.
Throughout their lives, individuals accumulate and apply lessons learned from instruction and experience. It is unclear how they transfer these lessons to become accomplished in their fields. In this exploratory study, we develop grounded hypotheses about the relationship of transfer to accomplishment. Selected individuals told stories about what they learned that influenced their major accomplishments, their sources, and timing. Findings indicate that individuality is magnified on the road to accomplishment, although shared lessons were evident. Attitudes and values, adopted and applied, seemed to play a special role in the passage from transfer to accomplishment. 相似文献
90.
Sammy Perone Stephen J. Molitor Aaron T. Buss John P. Spencer Larissa K. Samuelson 《Child development》2015,86(3):812-827
Executive functions enable flexible thinking, something young children are notoriously bad at. For instance, in the dimensional change card sort (DCCS) task, 3‐year‐olds can sort cards by one dimension (shape), but continue to sort by this dimension when asked to switch (to color). This study tests a prediction of a dynamic neural field model that prior experience with the postswitch dimension can enhance 3‐year‐olds' performance in the DCCS. In Experiment 1A, a matching game was used to preexpose 3‐year‐olds (n = 36) to color. This facilitated switching from sorting by shape to color. In 3 , 3‐year‐olds (n = 18) were preexposed to shape. This did not facilitate switching from sorting by color to shape. The model was used to explain this asymmetry. 相似文献