Constructing identities in online communities of practice – By Leila Kajee     

Ramesh C Sharma 《British journal of educational technology : journal of the Council for Educational Technology》2009,40(5):965-966

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Governing Difficult Knowledge: The Canadian Museum for Human Rights and Its Publics     

Karen Sharma 《Review of Education, Pedagogy & Cultural Studies》2015,37(2-3):184-206

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Interleukin-6 Perpetrator of the COVID-19 Cytokine Storm     

Jyoti Shekhawat  Kavya Gauba  Shruti Gupta  Purvi Purohit  Prasenjit Mitra  Mahendra Garg  Sanjeev Misra  Praveen Sharma  Mithu Banerjee 《Indian journal of clinical biochemistry : IJCB》2021,36(4):440

COVID-19 has emerged as a global pandemic. It is mainly manifested as pneumonia which may deteriorate into severe respiratory failure. The major hallmark of the disease is the systemic inflammatory immune response characterized by Cytokine Storm (CS). CS is marked by elevated levels of inflammatory cytokines, mainly interleukin-6 (IL-6), IL-8, IL-10, tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Of these, IL-6 is found to be significantly associated with higher mortality. IL-6 is also a robust marker for predicting disease prognosis and deterioration of clinical profile. In this review, the pivotal role played by IL-6 in the immuno-pathology of COVID-19 has been illustrated. The role of IL-6 as a pleiotropic cytokine executing both pro and anti-inflammatory activities has been reviewed. ADAM 10, a metalloproteinase switches the anti-inflammatory pathway of IL-6 to pro inflammatory hence blocking the action of ADAM 10 could be a new therapeutic strategy to mitigate the proinflammatory action of IL-6. Furthermore, we explore the role of anti-IL6 agents, IL-6 receptor antibodies which were being used for autoimmune diseases but now are being repurposed for the therapy of COVID-19.  相似文献   

Thormann,Joan & Zimmerman,Isa Kaftal (2012) Complete step‐to‐step guide to designing and teaching online courses Teachers College Press (Columbia University,NY & Eurospan,London) isbn 978‐0‐8077‐5309‐5 216 pp £26.95 http://store.tcpress.com/0807753092.shtml     

Ramesh Sharma 《British journal of educational technology : journal of the Council for Educational Technology》2013,44(2):E68-E69

This is a highly useful illustrative step‐by‐step resource for teachers and administrators planning for or already teaching online. It offers great ideas, strategies, practical examples, online tools and design principles for all those associated with online teaching, whether they are beginners or experienced. I recommend you buy a copy of this book for your own use if its content is likely to be relevant to you. Ramesh Sharma  相似文献   

Shifting South African learners towards greater autonomy in scientific investigations     

Umesh Ramnarain 《课程研究杂志》2013,45(1):94-121

This report describes how teachers support ninth-grade students who are doing scientific investigations in Natural Sciences in South African schools. This is of interest as allowing students to participate in inquiry-based investigations is a significant shift from traditional practices. It presents a new challenge to teachers as it signals an opportunity to shift from a teacher-centred to a student-centred approach in practical inquiry. The research study adopted a mixed methodology research design that involved the collection of both quantitative and qualitative data. The quantitative data were collected by means of questionnaires that were administered to 55 teachers. Qualitative data were collected by means of five classroom observations of student investigations and in-depth teacher interviews. The analysis of all the data revealed that teachers believe in providing support and not allowing learners to discover for themselves when participating in investigations. Teachers use a number of support strategies depending on the stage of the investigation. Based on these findings, a learning progression of teacher support for increasing learner autonomy was formulated which teachers can use in guiding them in the use of appropriate support strategies as they shift students towards greater autonomy in doing investigations.  相似文献   

Perspectives of ‘STEM education and policies’ for the development of a skilled workforce in Australia and India     

Jyoti Sharma  Prasad KDV Yarlagadda 《International Journal of Science Education》2013,35(16):1999-2022

ABSTRACT

In an increasingly competitive world, it has been proved that invention, development, and profusion of new technologies through science and technology are the fundamental source of economic progress. Australia, which is one of the world leaders in education and India, which has the capacity to produce the highest number of young skilled manpower to lead the world, both understand the current situation and have signalled their commitment to restoring the national strategy for STEM education. The proposed study focuses on a comparative understanding of the interplay of inclusive policies, government’s initiatives, knowledge gap from the literature and potential future challenges that Australia and India could face in STEM education at the school level. The question we asked is: what are the important inferences and best practices in STEM education that can be mutually beneficial to broaden the Strategic Partnership? It is identified that the governments of both the countries are determined to utilise the young population to train them as skilled workforce in order to meet the future demand of industries. Australia’s constructivist approach to education and the well-defined system of vocational training outperform India, which is still following the traditional approach. However, Australia has failed to engage students adequately in STEM and needs to revisit the efficacy of the current education model, while India needs to espouse the well-defined Australian framework, which could help to enhance quality infrastructure, curriculum, constructivist teaching and transparent policy implementation. In addition, both the nations must work hard to attract bright students in the teaching profession in order to promote a conducive environment for scientific learning.  相似文献   

Diagnostic Value of PCR in Genitourinary Tuberculosis     

Narotam Sharma  Veena Sharma  Prem Raj Singh  Shivani Sailwal  Rajeev S. Kushwaha  Rajesh K. Singh  Satish C. Nautiyal  Pankaj Mishra  Tariq Masood  R. K. Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(3):305-308

Genitourinary tuberculosis is a disease of the genitourinary system which includes the entire urinary tract and reproductive system. Genital tuberculosis is an important cause of female infertility, especially in developing nations like India. In the present study, a total of 257 clinical specimens comprising of endometrial biopsy (109), endometrial curetting (42), menstrual blood (8), semen (17), placenta (11) and urine (70) were collected from patients and subjected for PCR, Culture and AFB detection. The endometrial biopsy, endometrial curetting, menstrual blood, semen, placenta, urine showed 30.2, 45.2,12.5, 5.8, 27.2, 31.4 %, positivity rate for tuberculosis by PCR, 7.3, 9.5, 25.0, 0, 9, 8.5 % by culture and 1.8, 2.3, 0, 0, 0, 2.8 % respectively by AFB smear. Being a novel, rapid technique, PCR is the method of choice for rapid diagnosis and management of genitourinary tuberculosis shared with the other concerned tests. This study reveals that genital tuberculosis can occur in any age group, however, the majority of patients were from reproductive age (nearly 75 % of them were from 20–45 years of age) group.  相似文献   

Effect of Growth Hormone on Plasminogen Activator and Inhibitor Activity in Rat     

P. Bubber  A. Sharma  A. Chauhan  D. D. Bansal 《Indian journal of clinical biochemistry : IJCB》2013,28(2):193-196

Growth retardation is one of the significant changes in chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Disturbances in growth hormone (GH) are held responsible for several complications in CKD. GH is a protein based peptide hormone which directly or indirectly regulates renal functions to ensure homeostasis. We investigated the effects of growth hormone on plasminogen activators (PA) in rat kidney, PA and plasminogen activator inhibitor (PAI), glucose and fibrinogen in plasma and serum lipid profile. Rats were injected daily with 250 mU GH kg-1 body weight subcutaneously for one week. Growth hormone treatment increased PA activity significantly in rat kidneys as compared to controls. No changes were seen in PA, PAI and fibrinogen levels in the plasma of two groups of rats. There was significant decrease in plasma glucose, total cholesterol and LDL-cholesterol levels in serum of treated group resulting in the decrease of HDL/LDL and total cholesterol/cholesterol ratios. However, triglycerides and VLDL showed significant higher activity in the serum of treated group as compared to controls. Our data suggests that GH administration might improve renal function by increasing PA activity in kidney as well as by reducing the cholesterol content in blood. GH may be effective in improving growth failure as it helps to maintain the normal homeostatic balance.  相似文献   

Standardized testing – By Richard P Phelps     

Ramesh C. Sharma 《British journal of educational technology : journal of the Council for Educational Technology》2009,40(3):590-591

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Studies on the management of root-knot nematode, Meloidogyne incognita -wilt fungus, Fusarium oxysporum disease complex of green gram, Vigna radiata cv ML-1108     

Haseeb Akhtar  Sharma Anita  Shukla Prabhat Kumar 《Journal of Zhejiang University. Science. B》2005,6(8):736-742

Studies were conducted under pot conditions to determine the comparative efficacy of carbofuran at 1 mg a.i./kg soil, bavistin at 1 mg a.i./kg soil, neem (Azadirachta indica) seed powder at 50 mg/kg soil, green mould (Trichoderma harzianum) at 50.0 ml/kg soil, rhizobacteria (Pseudomonas fluorescens) at 50.0 ml/kg soil against root-knot nematode,Meloidogyne incognita-wilt fungus,Fusarium oxysporum disease complex on green gram,Vigna radiata cv ML-1108. All the treatments significantly improved the growth of the plants as compared to untreated inoculated plants. Analysis of data showed that carbofuran andA. indica seed powder increased plant growth and yield significantly more in comparison to bavistin andP. fluorescens. Carbofuran was highly effective against nematode, bavistin against fungus,A. indica seed powder against both the pathogens and both the bioagents were moderately effective against both the pathogens.  相似文献