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991.
Cynthia Jane A. V. Nerurkar F. R. Karjodkar 《Indian journal of clinical biochemistry : IJCB》2007,22(2):114-117
Oral Cancer is one of the five leading sites of cancer in Indian population. The circulating immune complexes were investigated
in 100 serum samples of 60 oral cancer patients having different grades of the disease and 40 patients with precancerous lesions
obtained from Nair Hospital Dental collage, Mumbai. The results obtained were compared with those of group of 40 healthy blood
donors. Elevated levels of Circulating Immune Complexes were observed in oral cancer patients and patients with oral precancerous
lesions. 92% positive samples were observed in well differentiated squamous cell carcinoma whereas 100% positive samples were
observed in both moderately and poorly differentiated squamous cell carcinoma. Oral leukoplakia and oral submucous fibrosis
showed 15% and 90% positivity respectively. Increased level of Circulating Immune complexes in high grade tumor suggest that
Circulating Immune complexes is likely to contribute in evaluating the degree of malignancy, but follow up study is needed
to draw any conclusion regarding it's prognostic role 相似文献
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Oliver K. Burmeister 《Ethics and Information Technology》2016,18(3):185-198
Developing technology that accounts for values has been achieved in many areas, including security, gaming, finance, engineering, and many more. The main methodological approach has been that of value sensitive design. But most of the work to date has been on the first of its three stages. The focus of this article is on advances related to its second stage, empirical investigation, and in particular the impact of contextual understanding in that stage. Although lessons can be learnt from other domains, the specific context of dementia means that there are nuances to understanding values, including justice and autonomy, that differ from other areas. The integration of value considerations in the development of assistive technology in dementia is explored in two broad categories: the traditional and ongoing need for fixed decision support, and adaptable decision support technologies. For fixed decision support the A&D Benchmark is particularly useful in design. But for adaptable technologies, that benchmark requires further development, including consideration of the values of additional stakeholders, such as the general public. 相似文献
995.
996.
Kapil Mehta 《Indian journal of clinical biochemistry : IJCB》1997,12(1):23-25
A rational approach for developing effective filaricides awaits greater knowledge on the biochemical pathways operating in filarial parasites. For example, metabolic pathways or key enzymes that are so pivotal to the parasite that their interruption or inhibition causes spontaneous death, could be exploited to develop effective chemotherapeutic agents. Similarly, developing a safe and nontoxic filaricidal will require precise understanding of whether or not the potential molecular target in the parasite is unique or at least different enough from the host system. Recently, we identified a novel transglutaminase enzyme (EC2.3.2.13; TGase) in filarial parasites that plays an important role during their normal growth and development. Based on these principles, TGase may serve as a new target for the development of effective chemotherapeutic agent and vaccine for controlling and preventing the infections caused by these parasites. 相似文献
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999.
Manaswini Mangaraj Rachita Nanda Suchismita Panda 《Indian journal of clinical biochemistry : IJCB》2016,31(3):253-259
Apolipoprotein A-I (apo A-I) an indispensable component and a major structural protein of high-density lipoprotein (HDL), plays a vital role in reverse cholesterol transport and cellular cholesterol homeostasis since its identification. Its multifunctional role in immunity, inflammation, apoptosis, viral, bacterial infection etc. has crossed its boundary of its potential of protecting cardiovascular system and lowering cardiovascular disease risk, attributing HDL to be known as a protective fat removal particle. Its structural homology with prostacyclin stabilization factor has contributed to its anti-clotting and anti-aggregatory effect on platelet which has potentiated its cardio-protective role as well as its therapeutic efficacy against Alzheimer’s disease. The binding affinity and neutralising action against endotoxin lipopolysaccharide, reduces the toxic manifestations of septic shock. As a negative acute phase protein, it blocks T-cell signalling of macrophages. However the recently identified anti-tumor activity of apo A-I has been highlighted in various models of melanoma, lung cancer, ovarian cancer, lymphoblastic leukaemia, gastric as well as pancreatic cancers. These cancer fighting effects are directed towards regression of tumor size and distant metastasis by its immuno modulatory activity as well as its clearing effect on serum lysophospholipids. This lowering effect on lysophospholipid concentration is utilized by apo A-I mimetic peptides to be used in retarding tumor cell proliferation and as a potential cancer therapeutic agent. Not only that, it inhibits the tumor associated neo-angiogenesis as well as brings down the matrix degrading enzymes associated with tumor metastasis. However this efficient therapeutic potential of apo A-I as an anti tumor agent awaits further future experimental studies in humans. 相似文献
1000.
Anita R. Bijoor S. Geetha T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):20-22
Malabsorption syndromes causing steatorrhoea are quite common in India. Estimation of faecal fat is an important non-invasive
investigation, which provides vital information regarding the occurrence of malabsorption. The aim of this study was to estimate
the fat excretion per day in stools of apparently healthy adults on an unrestricted diet in random spot stool samples using
the Acid Steatocrit Method, which provides an alternate, simpler and yet reliable method of stool fat estimation. Several
studies have proved the correlation of the acid steatocrit method with the conventional methods. In India, however, there
has been no published data regarding the normal levels of fat in the stools, by the acid steatocrit method. We follow the
normal range values, as set by the United States and the European countries, not having a range for the Indian population.
Hence, we took up a preliminary study, to estimate stool fat in a section of normal and healthy Indian population. The result
obtained after screening 600 healthy and normal adults, showed the mean of stool fat to be 8.72 gms/24 hours, which is much
higher than that, defined by Western literature (7 gms/24 hours). This can be accounted for, by the cultural and ethnic variations
in dietary and food habits. Further studies are required in the same direction, involving larger population groups, and in
different malabsorptive conditions. 相似文献