排序方式: 共有117条查询结果,搜索用时 93 毫秒
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He Liu Xia Jiang Ming-wu Zhang Yi-feng Pan Yun-xian Yu Shan-chun Zhang Xin-yuan Ma Qi-long Li Kun Chen 《Journal of Zhejiang University. Science. B》2013,14(1):47-57
The initiators caspase-9(CASP9) and caspase-10(CASP10) are two key controllers of apoptosis and play important roles in carcinogenesis.This study aims to explore the association between CASPs gene polymorphisms and colorectal cancer(CRC) susceptibility in a population-based study.A two-stage designed population-based case-control study was carried out,including a testing set with 300 cases and 296 controls and a validation set with 206 cases and 845 controls.A total of eight tag selected single nucleotide polymorphisms(SNPs) in CASP9 and CASP10 were chosen based on HapMap and the National Center of Biotechnology Information(NCBI) datasets and genotyped by restriction fragment length polymorphism(RFLP) assay.Multivariate logistic regression models were applied to evaluate the association of SNPs with CRC risk.In the first stage,from eight tag SNPs,three polymorphisms rs4646077(odds ratio(OR) AA+AG:0.654,95% confidence interval(CI):0.406-1.055;P=0.082),rs4233532(OR CC:1.667,95% CI:0.967-2.876;OR CT:1.435,95% CI:0.998-2.063;P=0.077),and rs2881930(OR CC:0.263,95% CI:0.095-0.728,P=0.036) showed possible association with CRC risk.However,none of the three SNPs,rs4646077(OR AA+AG:1.233,95% CI:0.903-1.683),rs4233532(OR CC:0.892,95% CI:0.640-1.243;OR CT:1.134,95% CI:0.897-1.433),and rs2881930(OR CC:1.096,95% CI:0.620-1.938;OR CT:1.009,95% CI:0.801-1.271),remained significant with CRC risk in the validation set,even after stratification for different tumor locations(colon or rectum).In addition,never tea drinking was associated with a significantly increased risk of CRC in testing set together with validation set(OR:1.755,95% CI:1.319-2.334).Our results found that polymorphisms of CASP9 and CASP10 genes may not contribute to CRC risk in Chinese population and thereby the large-scale case-control studies might be in consideration.In addition,tea drinking was a protective factor for CRC. 相似文献
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问新元 《湖北广播电视大学学报》2013,(12):133-134
在学前教育美术课程的教学中,装饰画占到了较大的比例和分量,如何教好这门课,使学生掌握知识,并学以致用,是教学工作者必须思考的问题.教学中对学生情感的引导,创造力的培养,和针对性的训练是学前教育装饰画教学的关键. 相似文献
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张心远 《北京城市学院学报》2012,(5):46-49,90
在开展普通高等学校本科教学工作合格评估的过程中,本科毕业论文(设计)与综合训练环节作为实践教学的重要环节,对本科专业与课程建设具有重要意义。在探索有特色的应用型高等教育培养模式的过程中,开展多样化的毕业综合训练是体现高校教学特色的重要举措之一。本文以北京城市学院英语(国际新闻采编)专业毕业综合训练试点为例,着力探讨通过提供多项选择开展毕业综合训练,实现应用型本科人才培养目标的途径。 相似文献
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东汉末年,魏王曹操在今河北省的大城、文安、黄骅以及河间的北部、天津市的静海县一带设置章武郡。章武郡至隋初撤,期间存370余年,是中原地区通往东北地区的战略要地。章武郡治始置地方,自唐以降,存在大城与黄骅两地矛盾的记载,至今一些专业人士还存在模糊认识。考证章武郡治地方,要放在东汉末年的政治、军事及地理状况中,进行考察、甄别,如此才能科学地辨别出何地是章武郡治始置地方。 相似文献
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张新元 《信阳师范学院学报(哲学社会科学版)》2004,24(6):50-52
大学英语测试,即四、六级考试,是西方现代语言测试理论与中国具体实际相结合的产物,是语言测试领域研究的持续热点,迄今争议不断,赞成主张继续坚持,反对主张立即取消。“取消论”主要源于对大学英语测试的认识偏差和尚欠科学的教学管理等。这些问题并非测试本身所固有,可以通过改革予以解决。大学英语测试是目前评价英语教学效果的最好体系,必将继续推动教学改革和英语人才的培养。 相似文献
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