Metabolic Syndrome in Childhood: Rare Case of Alstrom Syndrome with Blindness     

Afzal Ahmad  Benedicta D’Souza  Charu Yadav  Ashish Agarwal  Anand Kumar  M. Nandini  Vivian D’Souza  A. M. Poornima  Nutan Kamath 《Indian journal of clinical biochemistry : IJCB》2016,31(4):480-482

Alstrom’s syndrome (AS) is a rare autosomal recessive ciliopathic condition affecting 1:10,00,000 children. It’s a single gene disorder of ALMS1 on chromosome 2 with multisystem involvement with cone-rod retinal dystrophy causing juvenile blindness, obesity, insulin resistance, type 2 Diabetes mellitus, hypogonadism and sensorineural hearing loss. Till now only 800 patients with this disorder has been identified so far. In this report, we describe the case of a 9-year old male boy from south India. He had been initially referred for polyphagia, polyuria, polydipsia, generalized weakness from 1 weeks. On examination he was demonstrated features suggestive of AS, including blindness, obesity, type 2 diabetes, altered lipid profile, hypogonadism, acanthosis nigricans, seborrheic dermatitis, right ear discharge and episodes of respiratory tract infections. So, diagnosis of AS is critical as it can easily be overlooked because of the many features associated with metabolic syndrome starting at age 7, a relatively early age.  相似文献   

Hypolipidemic effect of water extract ofFicus bengalensis in alloxan induced diabetes mellitus in rabbits     

Rimi Shukla  Kiran Anand  K. M. Prabhu  P. Suryanarayana Murthy 《Indian journal of clinical biochemistry : IJCB》1995,10(2):119-121

Hypolipidemic effect of the water extract of the bark ofFicus bengalensis was investigated in alloxan induced diabetes mellitus in rabbits. Treatment for one month (50 mg/kg body weight/day) brought down the level of total serum cholesterol (TC) in subdiabetic and diabetic rabbits (five in each group) from 82±11 mg% and 118±10.6 mg% to 42.7±3.1 mg% and 51.7±4.7 mg% respectively. Low density lipoprotein cholesterol and very low density lipoprotein cholesterol values came down from 34±10 mg% and 95±24 mg% to 16±3 mg% and 29±4 mg% in subdiabetic and diabetic rabbits. Triacylglycerol level before treatment was 121±21.6 mg% and 416±70 mg% in subdiabetic and diabetic rabbits. Treatment brought it down to 45±5 mg% and 81±27.5 mg%. Glycosylated hemoglobin was brought down from 2.1±0.3% to 1.5±0.1% in subdiabetic group and from 4.28±0.5% to 2±0.3% in diabetic group, indicating that treatment with water extract effectively controlled blood sugar. After treatment with water extract serum lipid values were nearly equal to those in healthy controls (normal) in subdiabetic rabbits, while in diabetic group, the values were only slightly above those of normal.  相似文献   

Heart-Type Fatty Acid-Binding Protein,in Early Detection of Acute Myocardial Infarction: Comparison with CK-MB,Troponin I and Myoglobin     

Anand K. Pyati  Basavaraj B. Devaranavadagi  Sanjeev L. Sajjannar  Shashikant V. Nikam  Mohd. Shannawaz  Satish Patil 《Indian journal of clinical biochemistry : IJCB》2016,31(4):439-445

The study aimed to investigate whether heart-type fatty acid binding protein (H-FABP) measurement provides additional diagnostic value to that of conventional cardiac markers in acute myocardial infarction (AMI) within first 6 h after the onset of symptoms. The study included 120 subjects: 60 AMI cases and 60 age and sex matched controls. The cases and controls were further divided into 2 subgroups depending on the time since onset of chest pain as (1) subjects within 3 h and (2) between 3 and 6 h of onset of chest pain. In all the cases and controls, serum H-FABP concentration was measured by Immunoturbidimetric method, serum Troponin I and myoglobin concentrations by Chemiluminescence immunoassay and serum CK-MB concentration by Immuno-inhibition method. The sensitivity, specificity, positive and negative predictive values of H-FABP were significantly greater than CK-MB and myoglobin but were lesser than Troponin I in patients with suspected AMI in both within 3 h and 3–6 h groups. Receiver operating characteristic curves demonstrated greatest diagnostic ability for Troponin I (AUC = 0.99, p < 0.001) followed by H-FABP (AUC = 0.906, p < 0.001) within 3 h and 3–6 h after the onset of chest pain. In conclusion, the diagnostic value of H-FABP is greater than CK-MB and myoglobin but slightly lesser than troponin I for the early diagnosis of AMI within first 6 h of chest pain. H-FABP can be used as an additional diagnostic tool for the early diagnosis of AMI along with troponin I.  相似文献   

Effect of hemodialysis on circulating cystatin c levels in patients with end stage renal disease     

N. Krishnamurthy  K. Arumugasamy  U. Anand  C. V. Anand  V. Aruna  G. Venu  R. Gayathri 《Indian journal of clinical biochemistry : IJCB》2010,25(1):43-46

Plasma cystatin C is an emerging parameter to assess kidney function. Its utility in assessing the adequacy of hemodialysis in patients with end-stage-renal disease has however not been established with certainty. This study was therefore carried out to assess the usefulness of serum cystatin C estimation in patients undergoing low flux membrane hemodialysis. Serum creatinine and cystatin C were estimated in 20 patients before and after undergoing hemodialysis. The mean serum creatinine decreased from a pre-dialysis value of 7.72 mg/dL to a post-dialysis value of 2.90 mg/dL. On the contrary, the mean serum cystatin C levels were found to increase from a pre-dialysis value of 5.97 mg/L to a post-dialysis value of 8.25 mg/L. Therefore, serum cystatin C cannot be used to monitor dialysis adequacy. It however, serves as a surrogate marker of the inadequacy of low flux membrane bicarbonate hemodialysis in clearing low molecular weight proteins from the circulation.  相似文献   

Levels of plasma soluble complement receptor 1 (sCR1) in normal Indian adult population     

B. Sivasankar  K. R. Raju  V. Anand  S. Malu  S. Padmanabhan  S. C. Tiwari  Nibhriti Das  L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》1999,14(2):237-240

A decrease in the membrane anchored erythrocyte complement receptor 1 (CR1) is reported as an acquired phenomenon in a number of inflammatory and autoimmune diseases with concomitant rise in soluble CR1 (sCR1) levels in plasma. There is a need to establish the normal range of sCR1 in Indian adults to assess the function and disease association of this protein. The plasma sCR1 levels of 50 healthy individuals have been estimated by an indigenously developed sandwich ELISA. sCR1 levels from 26 patients suffering from nephropathies had also been assayed which was much higher than the normal controls. This observation suggests sCR1 as a potential market for the assessment of disease activity in nephropathies.  相似文献   

Serum Paraoxonase Levels In Patients with Acute Liver Disease     

Bindu CM  Anand U  Anand CV 《Indian journal of clinical biochemistry : IJCB》2011,26(3):230-234

Paraoxonase is an anti-oxidant enzyme, which circulates in the plasma, tightly bound to HDL. This enzyme is known to be synthesized in the liver. This study was carried out in order to ascertain the diagnostic utility of this enzyme in acute liver disease. Serum basal as well as salt (NaCl) stimulated paraoxonase was estimated in 50 patients with an established diagnosis of acute liver disease and also in 50 healthy blood donors. Paraoxonase levels were significantly lower in patients as compared with controls (P < 0.05). The ‘receiver operating characteristic’ plot showed that this enzyme has a high degree of sensitivity and specificity for the diagnosis acute liver disease. Serum PON is likely to emerge as an additional test of liver function, as it encompasses three different attributes of hepatic function namely, synthetic capacity, detoxication and secretory functions.  相似文献   

Serum Cystatin C Levels in Renal Transplant Recipients     

Krishnamurthy N  Arumugasamy K  Anand U  Anand CV  Aruna V  Venu G 《Indian journal of clinical biochemistry : IJCB》2011,26(2):120-124

Cystatin C is an emerging parameter for the assessment of renal allograft function. The objective of the study was to compare the efficacy of serum cystatin C (SCys) with the established parameter serum creatinine (SCr) in the assessment of renal function in renal transplant recipients (RTR). The glomerular filtration rate (GFR) of 30 renal transplant patients and 29 control subjects was determined using ^99mTc Diethylene-triamine-penta-acetate (DTPA) method. SCr was measured using an automated Jaffe’s assay and SCys was measured using latex particle enhanced turbidimetric immuno assay (PETIA). The modification of diet in renal disease (MDRD) formula was used to calculate GFR from SCr, while the Le Bricon formula was used to derive GFR based on SCys. Statistical analysis was performed using MedCalc software. SCr and SCys levels were significantly higher, while DTPA clearance was significantly lower in RTR (P < 0.0001) when compared with controls. The correlation coefficient (r value) between calculated GFR based on MDRD method and DTPA clearance was 0.343 (P = 0.06) while the calculated GFR based on Le Bricon formula was 0.694 (P < 0.001). The results have shown that SCys is a better parameter than SCr in assessing renal function in RTR. The inclusion of SCys as an additional parameter would certainly help in detection of even a marginal decline in renal function and also in adjusting the dosage of immunosuppressive drugs.  相似文献   

Wer hat einen Nutzen von Kompetenzmodellen?     

Hans Anand Pant 《Zeitschrift für Erziehungswissenschaft》2013,16(1):71-79

National educational standards (NES) were released in Germany 2003/2004 as obligatory performance standards substantively and normatively defining an acceptable degree of proficiency. The NES describe tangible competencies in the form of can-do statements for core subjects to be acquired by students at the end of defined stages of schooling. To evaluate standards-based performances the Standing Conference of the Ministers of Education and Cultural Affairs of the Federal States in Germany (KMK) implemented a test-based monitoring system that comprised a centralized evaluation in a nationwide study sample comparing the German federal states (Ländervergleich), as well as state-wide testing schemes at the end of grade 3 and grade 8 linked to the NES. All test items were designed by didactic experts on the basis of domain specific competence models that were psychometrically evaluated. The potential practical benefit from competence testing is discussed for the various system levels of feedback (state, school, teacher, and student). It is argued that, in order to tap the full potential of standards-based performance feedback, it must be appropriately communicated to the target system level and should be accompanied by suitable measures of action support.  相似文献   

A literature review of RFID-enabled healthcare applications and issues     

Samuel Fosso Wamba  Abhijith Anand  Lemuria Carter 《International Journal of Information Management》2013

Despite the rising implementation of RFID technology-based healthcare services, few empirical studies have been conducted to assess the potential of this technology within the healthcare sector. The purpose of this study is to help initiate and direct such empirical research by both conducting a review of the extant literature and using the findings to provide a discussion of current trends and future directions in this domain. In this paper, we develop a conceptual framework that can be used to classify publications on RFID applications and issues in the healthcare industry. We then use this framework to systematically summarize relevant articles. We conclude by highlighting future research directions where the deployment of RFID technology is likely to transform the healthcare sector.  相似文献   

Valide Erfassung der Kompetenzen von Studierenden in der Hochschulbildung     

Christiane Kuhn  Olga Zlatkin-Troitschanskaia  Hans Anand Pant  Bettina Hannover 《Zeitschrift für Erziehungswissenschaft》2016,19(2):275-298

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