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排序方式: 共有158条查询结果,搜索用时 15 毫秒
41.
Sarit K. Das Seok Chung Ioannis Zervantonakis Joseph Atnafu Roger D. Kamm 《Biomicrofluidics》2008,2(3)
Studies on the effects of variations in temperature and mild temperature gradients on cells, gels, and scaffolds are important from the viewpoint of biological function. Small differences in temperature are known to elicit significant variations in cell behavior and individual protein reactivity. For the study of thermal effects and gradients in vitro, it is important to develop microfluidic platforms which are capable of controlling temperature gradients in an environment which mimics the range of physiological conditions. In the present paper, such a microfluidic thermal gradient system (μTGS) system is proposed which can create and maintain a thermal gradient throughout a cell-seeded gel matrix using the hot and cold water supply integrated in the system in the form of a countercurrent heat exchanger. It is found that a uniform temperature gradient can be created and maintained in the device even inside a high temperature and high humidity environment of an incubator. With the help of a hot and cold circuit controlled from outside the incubator the temperature gradient can be regulated. A numerical simulation of the device demonstrates the thermal feature of the chip. Cell viability and activity under a thermal gradient are examined by placing human breast cancer cells in the device. 相似文献
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Sudhesna Mohapatra Teresa Biswas Saswati Das Alpana Saxena 《Indian journal of clinical biochemistry : IJCB》2014,29(1):112-113
Alkaptonuria or ochronosis is a rare inborn disorder of metabolism which is characterized by deficiency of homogentisic acid oxidase. There is accumulation of homogentisic acid in the connective tissues causing brownish black pigmentation and skeletal damage. The most serious complication of this disease is crippling degenerative arthropathy which presents in late years of life. There is no definitive treatment for the condition. Symptomatic management is the main stay. Surgical management such as arthroplasty is done for severe cases of ochronosis. We report a case of ochronosis of the hip joint presenting with inflammation and lytic lesion which can create confusion and lead to error in diagnosis. 相似文献
44.
Rituparna Maji Sukla Nath Surajit Lahiri Mita Saha Das Ajit Ranjan Bhattacharyya Harendra Nath Das 《Indian journal of clinical biochemistry : IJCB》2014,29(2):167-173
Reference intervals (RIs) of serum thyroid stimulating hormone (TSH) and free thyroxine (fT4) were determined in 402 healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after partitioning them into three trimesters. The reference population was chosen from a study population of 610 pregnant females by applying strict inclusion and exclusion criteria. The assays were done using proper quality control measures. RIs were calculated from the central 95 % of the distribution of TSH and fT4 values located between the lower reference limit of 2.5 percentile and upper reference limit of 97.5 percentile value 0.90 confidence intervals for the upper and lower reference limits were also determined. The reference intervals for TSH were 0.25–3.35 μIU/ml for the first trimester; 0.78–4.96 μIU/ml for the second trimester and 0.89–4.6 μIU/ml for the third trimester. Similarly, the reference intervals for fT4 for first, second and third trimesters were 0.64–2.0, 0.53–2.12 and 0.64–1.98 ng/dl respectively. The values thus obtained varied from those provided by the kit literature. In comparison to our derived reference intervals, the reference data from kit manufacturer under-diagnosed both subclinical hypo- and hyper-thyroidism within our pregnant reference population. 相似文献
45.
A preliminary survey of professionalism teaching practices in anatomy education among Indian Medical Colleges 下载免费PDF全文
Ilavenil Karunakaran Ponniah Thirumalaikolundusubramanian Sheela Das Nalinakumari 《Anatomical sciences education》2017,10(5):433-443
Professionalism and ethics have gained widespread recognition as competencies to be fulfilled, taught, and assessed within medical education. The role of the anatomy course in developed nations has evolved over time and now encompasses multiple domains, including knowledge, skills, and the inculcation of professionalism and ethics. The Medical Council of India recently recommended the integration of professionalism teaching in undergraduate medical curricula. The authors investigated whether the initial orientation lectures and instructions given by faculty at the outset of undergraduate medical anatomy courses throughout India served a “hidden curriculum” regarding professionalism practices, and whether these orientation messages could serve as an early exposure to medical professionalism and ethics for medical students. An online survey was carried out among 102 anatomy faculty members across India requesting details about specific professionalism protocols and instructions regarding behavior in the dissection hall that are routinely given to preclinical students, as well as the importance that they placed on professional behavior. It was found that most faculty members regularly instruct students regarding expected behavior during the anatomy course, including dissection practices. These instructions stress attributes of professionalism like humanism, accountability, and honesty. However, there needs to be a more concentrated effort by educators to prohibit such unprofessional practices like dissection hall photography, and better information is required regarding biomedical waste disposal. Despite the absence of clear guidelines for professionalism teaching in medical education in India, the existing framework of anatomy education provides an opportunity to introduce the concept of professionalism to the first‐year medical student. This opportunity may provide an early foundation for designing a professionalism‐integrated curriculum. Anat Sci Educ 10: 433–443. © 2017 American Association of Anatomists. 相似文献
46.
Maternal mind-mindedness and attachment security as predictors of theory of mind understanding 总被引:1,自引:0,他引:1
Meins E Fernyhough C Wainwright R Das Gupta M Fradley E Tuckey M 《Child development》2002,73(6):1715-1726
This study investigated relations between social interaction during infancy and children's subsequent theory of mind (ToM). Infant-mother pairs (N = 57) were observed in a free-play context at 6 months. Interactions were coded for (a) mothers' use of mental state language that commented appropriately on the infants' mental states, and (b) mothers' use of mental state language that did not appropriately reflect their infants' minds. A third variable was (c) security of attachment, which was assessed using the Strange Situation procedure at 12 months. Performance on a battery of ToM tasks at 45 and 48 months was positively correlated with (a), but was not related to (b) or (c). A regression analysis showed that mothers' use of appropriate mental state comments independently predicted overall ToM performance, accounting for 11% of the variance. Children's verbal ability was the only other independent predictor of ToM performance, accounting for 16% of the variance. These findings represent the earliest known social predictor of individual differences in ToM. 相似文献
47.
The 2006 Nobel Prize in Physiology or Medicine was awarded to Andrew Fire and Craig Mello for discovering “RNA interference—genesilencing
by double-stranded RNA”. The Nobel Committee at the Karolinska Institute in Sweden selected them for the award for unraveling
“a fundamental mechanism for controlling the flow of genetic information” that is “already being widely used in basic science
as a method to study the function of genes and may lead to novel therapies in the future”. This has been one of the fastest
Nobel Prizes conferred in physiology or medicine, considering that Fire and Mello published their path-breaking article in
the journal Nature in 1998, less than ten years ago.
Utpal Nath is an Assistant Professor in the Department of Microbiology and Cell Biology, IISc. His laboratory is studying
the genetic mechanisms of plant development.
Saumitra Das is an Associate Professor in the Department of Microbiology and Cell Biology, IISc. His laboratory is interested
in the translational control of cellular and viral RNA. 相似文献
48.
49.
Sanju Jalla Sunil Sazawal Salkat Deb robert E. Black Satya Narayan Das Archana Sarkar Maharaj K. Bhan 《Indian journal of clinical biochemistry : IJCB》2004,19(2):95-99
Lymphocyte subset estimations by flow cytometry in population-based studies require transportation of samples from the field
site to the laboratory. As samples arrive late in the day they have to wait overnight before being processed. The effect of
two possible approaches, sample storage for 24 h before staining and immediate staining with analysis after 24 h and 48 h
were evaluated. Two sets of experiments were performed with EDTA (ethylenediamine tetra-acetate) anticoagulated peripheral
blood. In the first experiment, after collection, each sample was divided into two portions. One portion was stained at the
time of blood collection and the other 24 h later after keeping it at room temperature (38–45°C). In the second experiment,
blood samples were stained within 1–2 h. Each sample was analyzed immediately upon completion of staining process and subsequently
after 24 h and 48 h of storage at 4°C. Results suggest that blood collected in EDTA can be processed using whole blood lysis
method, after storage at room temperature (38–45°C) for 24 h with some but not significant alteration in T-cell subsets. Storage
at 4°C after staining for 24 h results in a lesser and insignificant loss of cells or alteration of T-cell subsets and may
be the method of choice. 相似文献
50.
Subir Kumar Das Prasunpriya Nayak D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(2):111-118
A variety of laboratory tests are available to assist in the diagnosis of alcohol consumption and related disorders. The levels
of intake at which laboratory results become abnormal vary from person to person. Laboratory tests are particularly useful
in settings where cooperativeness is suspected or when a history is not available. Several biochemical and hematological tests,
such as γ-glutamyltransferase (GGT) activity, aspartate aminotransferase (AST) activity, high-density lipoprotein cholesterol
(HDL-C) content of serum, and erythrocyte mean corpuscular volume (MCV) are established markers of alcohol intake. Their validity
as markers is based largely on correlations with recent intake at a single time point and on decreases in elevated values
when heavy drinkers abstain from alcohol. These readily available laboratory tests provide important prognostic information
and should be integral part of the assessment of persons with hazardous alcohol consumption. There are several other markers
with considerable potential for more accurate reflection of recent alcohol intake. These include carbohydrate deficient transferrin,
β-hexosaminidase, acetaldehyde adducts and the urinary ratio of serotonin metabolites, 5-hydroxytryptophol and 5-hydroxyindoleacetic
acid. These markers provide hope for more sensitive and specific aids to diagnosis and improved monitoring for intake. 相似文献