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11.
Iida H Kato S Sekino Y Sakai E Uchiyama T Endo H Hosono K Sakamoto Y Fujita K Yoneda M Koide T Takahashi H Tokoro C Goto A Abe Y Kobayashi N Kubota K Gotoh E Maeda S Nakajima A Inamori M 《Journal of Zhejiang University. Science. B》2012,13(1):29-34
Objective
The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress-related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg.Methods
Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period.Results
During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole (median: 4.45 vs. 2.65; P=0.0367). Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg (median: 90.6% vs. 55.2%, P=0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively).Conclusions
In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. 相似文献12.
A word problem that requires addition of fractions with different denominators was presented to 11 classes of 4th- or 5th-graders, 10 years of age. It had three answer alternatives: adding the denominators and numerators separately, transforming fractions into decimals before adding them, and the standard, most appropriate solution. Students in each class were required to choose an alternative themselves, state their reason for the choice, and discuss which alternative would be right. After whole-class discussion, they were asked to choose an alternative again and nominate the student who had offered the most plausible idea. Then students in six classes were informed which alternative was the most appropriate, whereas those in five classes were not. Finally, the students, irrespective of the presence/absence of feedback, were required to solve the initial problem without the alternatives as the post-test, and two new problems as the transfer test.The results showed that (a) the students could offer more or less plausible arguments for or against each alternative, which in most classes included the correct explanation; (b) both vocal and silent students could write a mathematical expression for the post-test problem and manipulated it correctly, incorporating other students' ideas presented during the discussion, with or without the teacher's feedback, though their generalization was rather limited; and (c) the students could recognize and memorize reasonable explanations offered by other students in the discussion. 相似文献
13.
Eiji Muraki 《Journal of Educational Measurement》1999,36(3):217-232
Bock, Muraki, and Pfeiffenberger (1988) proposed a dichotomous item response theory (IRT) model for the detection of differential item functioning (DIF), and they estimated the IRT parameters and the means and standard deviations of the multiple latent trait distributions. This IRT DIF detection method is extended to the partial credit model (Masters, 1982; Muraki, 1993) and presented as one of the multiple-group IRT models. Uniform and non-uniform DIF items and heterogeneous latent trait distributions were used to generate polytomous responses of multiple groups. The DIF method was applied to this simulated data using a stepwise procedure. The standardized DIF measures for slope and item location parameters successfully detected the non-uniform and uniform DIF items as well as recovered the means and standard deviations of the latent trait distributions.This stepwise DIF analysis based on the multiple-group partial credit model was then applied to the National Assessment of Educational Progress (NAEP) writing trend data. 相似文献
14.
Joseph P. Allen Meghan A. Costello Amanda F. Hellwig Corey Pettit Jessica A. Stern Bert N. Uchino 《Child development》2023,94(6):1610-1624
Adolescent success providing satisfying support in response to a close friend's call in a caregiving task was examined as a potentially fundamental developmental competence likely to predict future social functioning, adult caregiving security, and physical health. Adolescents (86 males, 98 females; 58% White, 29% African American, 8% mixed race/ethnicity, 5% other) were followed from ages 13 to 33 (1998–2021) using multiple methods and reporters. Early caregiving success was found to predict greater self- and partner-reported caregiving security, lower negativity in adult relationships, and higher adult vagal tone. Results are interpreted as advancing our understanding beyond simply recognizing that adolescent friendships have long-term import, to now identifying specific capacities within friendships that are linked to longer-term outcomes. 相似文献