The political economy of applied research: Plant breeding in Great Britain, 1910–1940     

Paolo Palladino 《Minerva》1990,28(4):446-468

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Could light meal jeopardize laboratory coagulation tests?     

Gabriel Lima-Oliveira  Gian Luca Salvagno  Giuseppe Lippi  Elisa Danese  Matteo Gelati  Martina Montagnana  Geraldo Picheth  Gian Cesare Guidi 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(3):343-349

Background:

Presently the necessity of fasting time for coagulation tests is not standardized. Our hypothesis is that this can harm patient safety. This study is aimed at evaluating whether a light meal (i.e. breakfast) can jeopardize laboratory coagulation tests.

Materials and methods:

A blood sample was firstly collected from 17 fasting volunteers (12 h). Immediately after blood collection, the volunteers consumed a light meal. Then samples were collected at 1, 2 and 4 h after the meal. Coagulation tests included: activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (Fbg), antithrombin III (AT), protein C (PC) and protein S (PS). Differences between samples were assessed by Wilcoxon ranked-pairs test. The level of statistical significance was set at P < 0.05. Mean % differences were determined and differences between and baseline and 1, 2 and 4h samples were compared with reference change value (RCV).

Results:

A significantly higher % activity of AT was observed at 1 h and 4 h after meal vs. baseline specimen [113 (104–117) and 111 (107–120) vs. 109 (102–118), respectively; P = 0.029 and P = 0.016]. APTT at 2 h was found significantly lower than baseline samples [32.0 (29.9–34.8) vs. 34.1 (32.2–35.2), respectively; P = 0.041]. The results of both Fbg and PS tests were not influenced by a light meal. Furthermore, no coagulation tests had significant variation after comparison with RCV.

Conclusion:

A light meal does not influence the laboratory coagulation tests we assessed, but we suggest that the laboratory quality managers standardize the fasting time for all blood tests at 12 hours, to completely metabolize the lipids intake.  相似文献   

Science or graduates: How do firms benefit from the proximity of universities?     

Bart Leten  Paolo Landoni  Bart Van Looy 《Research Policy》2014

This paper examines the impact of universities on the technological performance of adjacent firms. We extend existing research by jointly analyzing, and comparing, the effects of education (graduates) and scientific research (publications) activities of universities on firms’ technological performance. Adopting the knowledge production framework, our study is conducted at the level of 101 Italian territorial areas (provinces) and four industries. Overall, fixed-effect panel data models reveal a positive effect of both university graduates and scientific publications on the technological performance of firms. At the same time, considerable industry differences are observed. While the provision of university graduates positively affects firm performance in all industries under study, additional effects for scientific research are only observed in electrical and pharmaceutical industries that are science-intensive and where the scientific knowledge base is changing rapidly over time. The observation that spillovers from academia into the industrial texture of provinces rely on education and research in an industry-specific manner is relevant to the design of appropriate research and innovation policies.  相似文献   

Evaluating the Power of Latent Growth Curve Models to Detect Individual Differences in Change     

Christopher Hertzog  Timo von Oertzen  Paolo Ghisletta  Ulman Lindenberger 《Structural equation modeling》2013,20(4):541-563

We evaluated the statistical power of single-indicator latent growth curve models to detect individual differences in change (variances of latent slopes) as a function of sample size, number of longitudinal measurement occasions, and growth curve reliability. We recommend the 2 degree-of-freedom generalized test assessing loss of fit when both slope-related random effects, the slope variance and intercept-slope covariance, are fixed to 0. Statistical power to detect individual differences in change is low to moderate unless the residual error variance is low, sample size is large, and there are more than four measurement occasions. The generalized test has greater power than a specific test isolating the hypothesis of zero slope variance, except when the true slope variance is close to 0, and has uniformly superior power to a Wald test based on the estimated slope variance.  相似文献   

Evaluation of hematocrit bias on blood glucose measurement with six different portable glucose meters     

Daves M  Cemin R  Fattor B  Cosio G  Salvagno GL  Rizza F  Lippi G 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2011,21(3):306-311

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A strange horn between Paolo Mantegazza and Charles Darwin     

Carla Garbarino  Paolo Mazzarello 《Endeavour》2013

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Acute effects of whole-body vibration on running gait in marathon runners     

Johnny Padulo  Davide Filingeri  Karim Chamari  Gian Mario Migliaccio  Giuseppe Calcagno  Gerardo Bosco 《Journal of sports sciences》2013,31(12):1120-1126

Abstract

The aim of this study was to investigate the effects of a single bout of whole-body vibration (WBV) on running gait. The running kinematic of sixteen male marathon runners was assessed on a treadmill at iso-efficiency speed after 10 min of WBV and SHAM (i.e. no WBV) conditions. A high-speed camera (210 Hz) was used for the video analysis and heart rate (HR) was also monitored. The following parameters were investigated: step length (SL), flight time (FT), step frequency (SF), contact time (CT), HR and the internal work (W_INT). Full-within one-way analysis of variance (ANOVA) of the randomised crossover design indicated that when compared to SHAM conditions, WBV decreased the SL and the FT by ~4% (P < 0.0001) and ~7.2% (P < 0.001), respectively, and increased the SF ~4% (P < 0.0001) while the CT was not changed. This effect occurred during the first minute of running: the SL decreased ~3.5% (P < 0.001) and SF increased ~3.3% (P < 0.001). During the second minute the SL decreased ~1.2% (P = 0.017) and the SF increased ~1.1% (P = 0.02). From the third minute onwards, there was a return to the pre-vibration condition. The W_INT was increased by ~4% (P < 0.0001) during the WBV condition. Ten minutes of WBV produced a significant alteration of the running kinematics during the first minutes post exposure. These results provide insights on the effects of WBV on the central components controlling muscle function.  相似文献   

Ginzburg in Harlem: History,Structure and the Politics of Primitivism     

Paolo Palladino 《Culture, Theory & Critique》2013,54(2):203-217

Abstract

The historian Carlo Ginzburg is renowned for his critique of modern, scientific reason and his articulation of an alternative form of knowledge which he labels ‘conjectural’. This form of knowledge, supposedly more attuned to the historian’s interest in the singular and specific fragment, as opposed to the abstract and universal concept, is so rooted in the practices of the prehistoric hunter that Ginzburg sometimes describes it as a ‘venatic’ form of deduction, binding ‘the human animal closely to other animal species’. In this essay, I explore the ramifications of this alternative form of knowledge, attending especially to its relationship to the modernist theme of ‘primitivism’. I do so by juxtaposing Ginzburg’s critical appraisal of Arthur Conan Doyle’s most famous literary invention, Sherlock Holmes, and Rudolph Fisher’s own literary invention, John Archer, the physician who sometimes aids criminal investigations in African American Harlem. I argue that the differences between Archer and Holmes draw attention to some troubling implications of Ginzburg’s historiographical argument. Folding this analysis on itself, however, I also suggest that what might be at stake, when Ginzburg insists so troublingly on the importance of the singular, venatic trace, is the evocation of Walter Benjamin’s understanding of the historical ‘event’.  相似文献   

Using the Web as corpus for self-training text categorization     

Rafael Guzmán-Cabrera  Manuel Montes-y-Gómez  Paolo Rosso  Luis Villaseñor-Pineda 《Information Retrieval》2009,12(3):400-415

Most current methods for automatic text categorization are based on supervised learning techniques and, therefore, they face the problem of requiring a great number of training instances to construct an accurate classifier. In order to tackle this problem, this paper proposes a new semi-supervised method for text categorization, which considers the automatic extraction of unlabeled examples from the Web and the application of an enriched self-training approach for the construction of the classifier. This method, even though language independent, is more pertinent for scenarios where large sets of labeled resources do not exist. That, for instance, could be the case of several application domains in different non-English languages such as Spanish. The experimental evaluation of the method was carried out in three different tasks and in two different languages. The achieved results demonstrate the applicability and usefulness of the proposed method.  相似文献   

Non-commutability of results of highly sensitive troponin I and T immunoassays     

Lippi G  Cervellin G  Aloe R  Montagnana M  Salvagno GL  Guidi GC 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):127-129

Introduction:

The measurement of cardiospecific troponins is pivotal in the diagnostic and prognostic approach of patients with suspected acute myocardial infarction (AMI). However, no information is available on the commutability of results between the novel highly-sensitive (HS) troponin T (TnT) and I (TnI) immunoassays.

Materials and methods:

The study population consisted in 47 consecutive patients presenting at the emergency department (ED) of the Academic Hospital of Parma with suspected AMI. TnI was measured with the novel prototype Beckman Coulter HS-AccuTnI immunoassay on Access 2, whereas TnT was measured with the Roche HS-TnT immunoassay on Cobas.

Results:

Eight out of the 47 patients (17%) were finally diagnosed as having an AMI. The overall correlation between TnT and TnI for total patient group was acceptable (r = 0.944; P < 0.01). Nevertheless, when the analysis of data was carried out in separate groups according to the final diagnosis of AMI, two different equation results were obtained, i.e., HS-TnT = HS-AccuTnI × 0.349 + 20 (r = 0.823; P < 0.01) in non-AMI patients, and HS-TnT = HS-AccuTnI × 0.134 + 67 (r = 0.972; P < 0.01) in those with AMI.

Conclusions:

This study suggests the existence of two biological relationships between TnI and TnT in plasma, depending on the source of release from the myocardium. Moreover, the non-commutability of data between HS-TnT and HS-AccuTnI jeopardizes the clinical decision making, makes it impossible to calculate the delta or reference change value using the two biomarkers and to finally establish a reliable kinetics of troponin release from the injured myocardium.  相似文献