Hybrid paradigms     

Dronamraju KR 《Endeavour》2006,30(2):41

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Preliminary study on circulating serum levels of tumor necrosis factor—Alpha in patients of tuberculosis     

Ritesh Gupta  H. Krishna Prasad  Kalpana M. Nagarkar  A. B. Dey 《Indian journal of clinical biochemistry : IJCB》2000,15(1):40-43

Tumor necrosis factor-alpha (TNF-α) has been implicated in the pathogenesis of several non-infectious and infectious diseases including tuberculosis. In a prospective longitudinal study, TNF-α level in blood was estimated by sandwich ELISA using anti human TNF-α antibody, in 22 patients with active pleuro-pulmonary and lymphnode tuberculosis before and after chemotherapy and 8 healthy controls. Six patients and six controls had detectable levels (> 5 pg/ml) of TNF-α in blood. The mean TNF-α levels in controls and cases before and after treatment were 182.4pg/ml, 896.7 pg/ml and 678.7pg/ml pg/ml respectively. Though not statistically significant, there was a trend towards younger age, shorter duration of symptoms, presence of fever and anorexia, and high ESR, in patient with high serum TNF-α levels.  相似文献   

Lipid peroxidation and antioxidant status in patients with rheumatoid arthritis     

Krishna Mohan Surapneni  V. S. Chandrasada Gopan 《Indian journal of clinical biochemistry : IJCB》2008,23(1):41-44

The changes in the erythrocyte lipid peroxidation products (MDA), levels of glutathione (GSH), ascorbic acid and plasma vitamin E (non enzymatic antioxidant parameters) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GP_X), catalase in erythrocytes and plasma glutathione - S - transferase (GST) activity were estimated in patients with rheumatoid arthritis. This work was undertaken to assess oxidative stress and anti oxidant status in patients with rheumatoid arthritis. It was observed that there was a significant increase in erythrocyte MDA levels, activities of SOD, GP_X, plasma GST and a significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin E levels and catalse activity in patients with rheumatoid arthritis when compared to controls. The results of our study suggests higher oxygen free radical production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and Catalase activity, support to the oxidative stress in rheumatoid arthritis. The increased activities of antioxidant enzymes may be a compensatory regulation in response to increased oxidative stress.  相似文献   

Ethnicity-based cultural differences in implicit managerial knowledge usage in three Australian organizations     

Debbie?RichardsEmail author  Peter?Busch  Krishna?Venkitachalam 《知识管理研究与实践》2007,5(3):173-185

This study was interested in determining whether ethnicity-based cultural differences affected knowledge usage in today's multicultural organizations. Our empirical study uses a psychology-based approach to measure what we refer to as implicit managerial knowledge of Information and Communication Technology (ICT) workers within three Australian organizations. The research instrument captures responses to various ICT workplace scenarios in order to determine and compare the different ways in which people make use of the implicit knowledge they use to manage themselves and others. Using the culture-based literature to assist with interpretation of the data, we have identified a number of themes and their characteristics and brought these together to provide a comprehensive model for understanding cultural influences. This model can be used to better appreciate why and perhaps anticipate how an individual's implicit managerial knowledge will be used in responding to everyday workplace situations. Such an understanding will assist organizations to develop appropriate and effective knowledge management strategies.  相似文献   

Therapy in Parkinson’s disease: Some recent developments     

Amit Krishna De 《Resonance》1999,4(5):78-87

Even though research is going on throughout the world, it is clear that at the present time there is really no cure for Parkinson’s disease. Treatment with drugs, with physiotherapy can slow down the progress of this disease. Treatment through brain grafting or reparative therapy using different nerve growth factors may be the only alternative for this disease. Researchers are still hoping that the newly discovered substances could one day help doctors treat this invincible disease and possibly cure it also.  相似文献   

Negotiating the (im)mobility of domestic work: Communicative erasures,disrupted embodiments,and neoliberal Asia     

Satveer Kaur-Gill  Mohan Jyoti Dutta 《Journal of International and Intercultural Communication》2020,13(2):130-150

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高校科研质量管理体系运行中的不符合项分析   总被引：1，自引：1，他引：0  

杨默函  张君  邱建国 《科技管理研究》2011,(3)

在对教育部直属的29所高校的科研质量管理体系运行情况调研的基础上,着重分析各校在体系运行中产生的不符合项及其原因,并进行与不符合项相关若干方面的深入讨论,最后提出不符合项分析与纠正的思路.  相似文献   

Graphical Representation of Missing Data Problems     

Felix Thoemmes  Karthika Mohan 《Structural equation modeling》2013,20(4):631-642

Rubin’s classic missingness mechanisms are central to handling missing data and minimizing biases that can arise due to missingness. However, the formulaic expressions that posit certain independencies among missing and observed data are difficult to grasp. As a result, applied researchers often rely on informal translations of these assumptions. We present a graphical representation of missing data mechanism, formalized in Mohan, Pearl, and Tian (2013). We show that graphical models provide a tool for comprehending, encoding, and communicating assumptions about the missingness process. Furthermore, we demonstrate on several examples how graph-theoretical criteria can determine if biases due to missing data might emerge in some estimates of interests and which auxiliary variables are needed to control for such biases, given assumptions about the missingness process.  相似文献   

Implementation of BTOP funding for public computing centers: Goal consensus and project performance     

Eun-A Park  Krishna Jayakar 《Government Information Quarterly》2013

This paper seeks to perform an assessment of the current state of implementation of BTOP-funded public computing center projects based on insights from principal–agent theory. Using newly available data on BTOP-funded PCC projects and correlating them with socioeconomic and geographic data derived from the US census and the FCC, we seek to assess whether program funds were targeted at unserved/underserved areas as required by program objectives, as well as the progress towards completion of PCC projects by type of grantee and funding amount. On the distribution of funds, we find that the PCCs supported were located in areas of high broadband availability as well as high demand: while this is contrary to the BTOP's stated purpose, we argue that it is actually more cost-effective to also target areas of high demand. It was also found that whereas a majority of PCC grants went to governmental agencies, who also received larger grants than non-governmental recipients, they were no more likely to generate a significantly higher percentage of matching funds or to move toward project completion sooner. We speculate that the intense competition for grants might have narrowed the performance gap between these categories of applicants.  相似文献   

Mucosal IgA & IL-1β in Helicobacter pylori Infection     

Ragini Srivastava  Antara Kashyap  Mohan Kumar  Gopal Nath  Ashok Kumar Jain 《Indian journal of clinical biochemistry : IJCB》2013,28(1):19-23

Helicobacter pylori infection stimulates strong local inflammatory and specific IgA antibody production. The influence of antibodies on the bacterial colonization is not clear. Here, we have analysed the association between the mucosal IgA level and IL-1β in various manifestations of the infection seen endoscopically. Antral biopsies of 57 dyspeptic patients were taken for culture, histology and estimation of mucosal levels of anti-H. pylori IgA and IL-1β. Mean mucosal IgA level was higher in patients with normal mucosa compared to all other groups and lower IgA level was associated with higher bacterial density. IL-1β was higher in ulcer patients and suspicious malignancy group as compared to normal group and higher level of IL-1β was associated with higher grades of metaplasia. Present study indicates that local immunity seems to have a protective role against H. pylori infection and higher level of IL-1β induced by the pathogen may be associated with metaplasia and carcinogenesis.  相似文献