Genetics of Obesity     

Apurva Srivastava  Neena Srivastava  Balraj Mittal 《Indian journal of clinical biochemistry : IJCB》2016,31(4):361-371

Numerous classical genetic studies have proved that genes are contributory factors for obesity. Genes are directly responsible for obesity associated disorders such as Bardet–Biedl and Prader–Willi syndromes. However, both genes as well as environment are associated with obesity in the general population. Genetic epidemiological approaches, particularly genome-wide association studies, have unraveled many genes which play important roles in human obesity. Elucidation of their biological functions can be very useful for understanding pathobiology of obesity. In the near future, further exploration of obesity genetics may help to develop useful diagnostic and predictive tests for obesity treatment.  相似文献   

My avatar,my self: Virtual harm and attachment   总被引：1，自引：0，他引：1  

Jessica Wolfendale 《Ethics and Information Technology》2007,9(2):111-119

Multi-user online environments involve millions of participants world-wide. In these online communities participants can use their online personas – avatars – to chat, fight, make friends, have sex, kill monsters and even get married. Unfortunately participants can also use their avatars to stalk, kill, sexually assault, steal from and torture each other. Despite attempts to minimise the likelihood of interpersonal virtual harm, programmers cannot remove all possibility of online deviant behaviour. Participants are often greatly distressed when their avatars are harmed by other participants’ malicious actions, yet there is a tendency in the literature on this topic to dismiss such distress as evidence of too great an involvement in and identification with the online character. In this paper I argue that this dismissal of virtual harm is based on a set of false assumptions about the nature of avatar attachment and its relation to genuine moral harm. I argue that we cannot dismiss avatar attachment as morally insignificant without being forced to also dismiss other, more acceptable, forms of attachment such as attachment to possessions, people and cultural objects and communities. Arguments against according moral significance to virtual harm fail because they do not reflect participants’ and programmers’ experiences and expectations of virtual communities and they have the unintended consequence of failing to grant significance to attachments that we take for granted, morally speaking. Avatar attachment is expressive of identity and self-conception and should therefore be accorded the moral significance we give to real-life attachments that play a similar role. A shorter version of this paper was presented at the Cyberspace 2005 Conference at Masaryk University, Brno, Czech Republic  相似文献   

Bancroftian filariasis in south east Madhya Pradesh: Pre-control epidemilogical observations     

Vandana Dixit  Ashok V. Kurup  A K Gupta  O M Kataria  G B K S Prasad 《Indian journal of clinical biochemistry : IJCB》1997,12(1):39-43

Lymphatic filariasis caused byWuchereria bancrofti is a major health problem next only to malaria. A study had been conducted to estimate the prevalence of microfilaraemia in a rural endemic community near Raipur. The incidence of microfilaramia in the community was found to be about 14% when studied by night finger prick method. The incidence appears to be more in males as compared to females. The infection rate in vector population i.e.,Culex quinquefasciatus was recorded at a rate of 10%. No relationship could be drawn between the rates of vector and human filarial infections or between the density of vector population and the rate of vector/human infection(s). Prior health education is essential before taking up control and preventive measures in given endemic zone.  相似文献   

Hyperhomocysteinemia,MMPs and Cochlear Function: A Short Review     

Seema Bhargava  Meghaa Shanta Bhargava  Eishaan Kamta Bhargava  LM Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(2):148-151

Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented.  相似文献   

Privacy,speech, and values: what we have no business knowing     

Adam D. Moore 《Ethics and Information Technology》2016,18(1):41-49

In the United States the ascendancy of speech protection is due to an expansive and unjustified view of the value or primacy of free expression and access to information. This is perhaps understandable, given that privacy has been understood as a mere interest, whereas speech rights have been seen as more fundamental. I have argued elsewhere that the “mere interest” view of privacy is false. Privacy, properly defined, is a necessary condition for human well-being or flourishing. The opening section of this article will provide an overview of this theory. Next, after a few remarks on speech absolutism, privacy absolutism, and balancing theories, I will sketch several of the dominant argument strands that have been offered in support of presumptively weighty speech rights. While these arguments, taken together, establish that free speech is important, they do not support the view that speech should nearly always trump privacy. In final section I will present and defend a way to balance free speech and privacy claims.  相似文献   

Superoxide dismutase and catalase activities and their correlation with malondialdehyde in schizophrenic patients     

Rukmini M. S.  Benedicta D'Souza  Vivian D'Souza 《Indian journal of clinical biochemistry : IJCB》2004,19(2):114-118

Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy radicals, such as superoxide, hydroxyl ions and nitric oxide) cause cell injury, when they are generated in excess or when the antioxidant defense is impaired. Both these processes seem to be affected in schizophrenia. In this study we investigated erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities as antioxidant enzymes, malondialdehyde (MDA) as a sign of lipid peroxidation in schizophrenic patients. Activities of superoxide dismutase, catalase and malondialdehyde were greater in patients compared with the control group which may reflect increased oxidative stress in the brain tissue of schizophrenics. In the patient group erythrocyte SOD and CAT activities were weakly negative correlated with MDA concentration. These data reveal that antioxidant defense mechanisms might be impaired in schizophrenic patients. These findings also provide a theoretical basis for the development of novel therapeutic strategies, such as antioxidant supplementation.  相似文献   

Overexpression of Aldose Reductase Render Mouse Hepatocytes More Sensitive to Acetaminophen Induced Oxidative Stress and Cell Death     

Munzir M. E. Ahmed  J. A. S. Al-Obosi  H. M. Osman  M. E. Shayoub 《Indian journal of clinical biochemistry : IJCB》2016,31(2):162-170

Acetaminophen (APAP) a commonly used drug for decrease the fever and pain but is capable to induced hepatotoxicity at over dose. This study was carried out to investigate the effect of APAP on the expression of anti-apoptotic and antioxidative defense genes, and whether aldose reductase over-expressing plasmid capable to protect against APAP-induced oxidative stress and cell death. APAP treatment induced oxidative stress and hepatotoxicity, and significantly increased aldose reductase mRNA and protein expression in mouse hepatocyte (AML-12). Unexpectedly, AML-12 cells over-expressing aldose reductase augmented APAP-induced reduction in cell viability, reactive oxygen species (ROS) production, glutathione (GSH) depletion and glutathione S-transferase A2 expression. Moreover, over-expression of aldose reductase potentiated APAP induced reduction on proliferating cell nuclear antigen, B cell lymphoma-extra large (bcl-x_L), catalase, glutathione peroxidase-1 (GPx-1) and abolished APAP-induced B-cell lymphoma 2 (bcl-2) inductions. Further, over-expression of aldose reductase significantly abolished AMP activated protein kinase (AMPK) activity in APAP-treated cells and induced p53 expression. This results demonstrate that APAP induced toxicity in AML-12, increased aldose reductase expression, and over-expression of aldose reductase render this cell more susceptible to APAP induced oxidative stress and cell death, this probably due to inhibition AMPK or bcl-2 activity, or may due to competition between aldose reductase and glutathione reductase for NADPH.  相似文献   

60亿人的死亡     

Michaelshermer何毓嵩  杨光 《科学中国》2003,(12):22-23

数千年来，人类一直对死亡异常恐惧，科学能够帮助我们摆脱这一宿命吗?  相似文献   

Effect of <Emphasis Type="SmallCaps">l</Emphasis>-Thyroxine on Micronuclei Frequency in Peripheral Blood Lymphocytes in Clinical and Experimental Conditions     

Yogita S. Raut  Uma S. Bhartiya  Purushottam Kand  Rohini W. Hawaldar  Ramesh V. Asopa  Lebana J. Joseph  MGR Rajan 《Indian journal of clinical biochemistry : IJCB》2016,31(1):99-103

The aim was to study the genotoxic effect of high concentration of thyroxine (T₄) in vivo in peripheral blood lymphocytes (PBL) of the patients suffering from thyroid disorders. The effect was compared by performing in vitro experiments with addition of increasing concentration of T₄ (0.125–1 µM) in whole blood samples from healthy donors. Cytokinesis-blocked micronuclei (CBMN) assay method was used to assess the DNA damage in the PBL. The study included 104 patients which were grouped as control (n = 49), hyperthyroid (n = 31) and hypothyroid (n = 24). A significant increase in micronuclei (MN) frequency was observed in hyperthyroid patients when compared with the hypothyroid and euthyroid group thereby suggesting increased genotoxicity in hyperthyroidism (p < 0.001). A significant increase in MN frequency was observed at T₄ concentration of 0.5 µM and above when compared to lower T₄ concentrations (0.125 and 0.25 µM) and basal in in vitro experiments (p = 0.000). The results indicate that the T₄ in normal concentration does not exhibit the genotoxic effect, as observed in both the in vivo and in vitro experiments. The toxicity of T₄ increases at and above 0.5 μM concentration in vitro. Therefore acute T₄ overdose should be handled promptly and effectively so as to avoid the possible genotoxic effect of high concentration of T₄ in vivo.  相似文献   

Mean square consensus of double-integrator multi-agent systems under intermittent control: A stochastic time scale approach     

Dylan Poulsen  Michael Defoort  Mohamed Djemai 《Journal of The Franklin Institute》2019,356(16):9076-9094

We consider the leader–follower consensus problem for a multi-agent system where information is exchanged only on a non-uniform discrete stochastic time domain. For a second-order multi-agent system subject to intermittent information exchange, we model the tracking error dynamics as a $\mu ?$varying linear system on a discrete stochastic time scale, where μ is the graininess operator. Based on a Lyapunov operator and a positive perturbation operator on the space of symmetric matrices, we derive necessary and sufficient conditions to design a decentralized consensus protocol. This protocol allows us to cast the mean-square exponential consensus problem within the framework of dynamic equations on stochastic time scales. We establish some theoretical results which allow for the computation of the control gain matrix which guarantees the mean-square exponential stability with a given decay rate for the error dynamics. To show the effectiveness of the theoretical results, some simulation and experimental results on multi-robot systems have been performed.  相似文献