Chlorella vulgaris triggers apoptosis in hepatocarcinogenesis-induced rats     

Emey Suhana Mohd Azamai  Suhaniza Sulaiman  Shafina Hanim Mohd Habib  Mee Lee Looi  Srijit Das  Nor Aini Abdul Hamid  Wan Zurinah Wan Ngah  Yasmin Anum Mohd Yusof 《Journal of Zhejiang University. Science. B》2009,10(1):14-21

Chlorella vulgaris (CV) has been reported to have antioxidant and anticancer properties. We evaluated the effect of CV on apoptotic regulator protein expression in liver cancer-induced rats. Male Wistar rats (200∼250 g) were divided into eight groups: control group (normal diet), CDE group (choline deficient diet supplemented with ethionine in drinking water to induce hepatocarcinogenesis), CV groups with three different doses of CV (50, 150, and 300 mg/kg body weight), and CDE groups treated with different doses of CV (50, 150, and 300 mg/kg body weight). Rats were sacrificed at various weeks and liver tissues were embedded in paraffin blocks for immunohistochemistry studies. CV, at increasing doses, decreased the expression of anti-apoptotic protein, Bcl-2, but increased the expression of pro-apoptotic protein, caspase 8, in CDE rats, which was correlated with decreased hepatoctyes proliferation and increased apoptosis as determined by bromodeoxy-uridine (BrdU) labeling and terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling (TUNEL) assay, respectively. Our study shows that CV has definite chemopreventive effect by inducing apoptosis via decreasing the expression of Bcl-2 and increasing the expression of caspase 8 in hepatocarcinogenesis-induced rats. Project supported by Department of Biochemistry, Faculty of Medicine, UKM Medical Center, Universiti Kebangsaan Malaysia, and the Malaysian Ministry of Science and Technological Innovation (MOSTI)  相似文献   

Analysing a cycling grand tour: Can we monitor fatigue with intensity or load ratios?     

Dajo Sanders  Mathieu Heijboer  Matthijs K. C. Hesselink  Tony Myers  Ibrahim Akubat 《Journal of sports sciences》2018,36(12):1385-1391

This study evaluated the changes in ratios of different intensity (rating of perceived exertion; RPE, heart rate; HR, power output; PO) and load measures (session-RPE; sRPE, individualized TRIMP; iTRIMP, Training Stress Score?; TSS) in professional cyclists. RPE, PO and HR data was collected from twelve professional cyclists (VO_2max 75 ± 6 ml?min?kg^?1) during a two-week baseline training period and during two cycling Grand Tours. Subjective:objective intensity (RPE:HR, RPE:PO) and load (sRPE:iTRIMP, sRPE:TSS) ratios and external:internal intensity (PO:HR) and load (TSS:iTRIMP) ratios were calculated for every session. Moderate to large increases in the RPE:HR, RPE:PO and sRPE:TSS ratios (d = 0.79–1.79) and small increases in the PO:HR and sRPE:iTRIMP ratio (d = 0.21–0.41) were observed during Grand Tours compared to baseline training data. Differences in the TSS:iTRIMP ratio were trivial to small (d = 0.03–0.27). Small to moderate week-to-week changes (d = 0.21–0.63) in the PO:HR, RPE:PO, RPE:HR, TSS:iTRIMP, sRPE:iTRIMP and sRPE:TSS were observed during the Grand Tour. Concluding, this study shows the value of using ratios of intensity and load measures in monitoring cyclists. Increases in ratios could reflect progressive fatigue that is not readily detected by changes in solitary intensity/load measures.  相似文献   

Factors affecting Turkish students＇ achievement in mathematics     

Ibrahim Demir Serpil Klllc Ozer Depren 《美中教育评论》2009,6(6):47-52,80

Following past researches, student background, learning strategies, self-related cognitions in mathematics and school climate variables were important for achievement. The purpose of this study was to identify a number of factors that represent the relationship among sets of interrelated variables using principal component factor analysis and examine the contribution of each factor to the explanation of the variance in the students＇ mathematics score using multiple regression analysis. The sample was prepared from students who participated in Programme for International Student Assessment （PISA） in Turkey. These data consisted of 3765 15 year-old Turkish students in 158 schools. The results showed that four factors under study totally accounted for approximately 34 percent of the variance in mathematics achievement. All of the factors had statistically significant effects on the achievement. The findings are very important for Turkish education system because the fact that changing school climate and improving the learning strategies are much easier to achieve than changing background factors affecting students＇ performance.  相似文献   

Effectiveness of the selected techniques in enhancing the achievement in science among the children with learning disabilities： Sharing experiences     

Mohd. Sahandri Gani Hamzah Vijayaletchumy a/p Subramamam Saifuddin Kumar Abdullah 《美中教育评论》2009,6(9):67-84

In national perception, education is essentially for all. This is fundamental to all-round development, material and spiritual. It refines sensitivities and perceptions that contribute to national cohesion, a scientific temper and independence of mind and spirit--thus furthering the goals of socialism secularism and democracy enshrined in our constitution. The objective of the study focuses on achievement of children with learning disability in science. There are 5 null hypothesis tested in this research. The sample used in this study includes 35 children with learning disabilities in experimental group and 42 children with learning disabilities in control group. The different views taken on special education have ignited spark of controversies over segregating some children from the mainstream and providing them with extra opportunities. There are arguments for and against both special education and integrated education. Special education means the specifically designed instruction that meets the unusual needs of special children. It requires special materials, teaching, techniques, equipment and facilities. The design was an experimental research pre and post-test equivalent group. The research shows that there is no significant difference in all learning objective such as knowledge, comprehension and skill between control group and experimental group in the pre-test. This two sample groups also did not show any significant difference in the pre-test irrespective of gender, educational qualification of the teacher, years of experience of the teacher, parents＇ education, parents＇ profession, parents＇ income, type of management and type of school. On the other hand, for the post-test all the characteristics show that there are significant differences. This shows that there are effects on the treatment group in learning objective. Furthermore the experimental group showed significantly higher gain score than the control group with regard to the learning objective which comprises of knowledge, comprehension, application and skill.  相似文献   

The effect of manufacturing strategy on organizational performance     

Raduan Che Rose  Naresh Kumar  Hazril Izwar Ibrahim 《Performance Improvement》2008,47(1):18-25

The research reported in this article investigated the effect of manufacturing strategy on organizational performance in the Malaysian electrical and electronic sector. It was revealed that a cost‐based strategy greatly affected the performance of organizations participating in this study. This result implied that a cost‐based strategy is still a dominant concern for manufacturing firms. The information gathered through this study is useful for strategy formulation and for understanding how a strategy can lead to improved organizational performance in general.  相似文献   

Plasma proteinase inhibitory activity in ectopic and molar pregnancy     

Maya Roche  V. P. Arun Kumar  S. M. Ibrahim  K. Nalini 《Indian journal of clinical biochemistry : IJCB》2008,23(4):352-355

Antitryptic, antichymotryptic and alpha 2- macroglobulin activities were measured in sera of normal nonpregnant and normal pregnant women and women with tubal ectopic pregnancy and molar pregnancies in the first 5 to 7 weeks of pregnancy calculated from the last menstrual period. While alpha 2-macroglobulin decreased in early normal pregnancy compared to nonpregnant state (p<0.001), in ectopic and molar pregnancies there was an increase in alpha 2- macroglobulin activity (p < 0.001), as compared to nonpregnant and normal pregnant women. Antitryptic activity did not increase in normal and ectopic pregnancy, however was increased in molar pregnancy (p < 0.01). Antichymotryptic activities did not show a change either in normal pregnancy or in cases of ectopic and molar pregnancy. Drop in alpha 2- macroglobulin activity to near normal levels in ectopic, 6 weeks post surgery, correlated well with the decrease in β-hCG. However, in molar pregnancy, alpha 2- macroglobulin remained elevated even when the β-hCG levels in serum returned to zero 10 weeks after surgery. The studies suggest a major role for circulating proteinase inhibitors especially alpha 2-macroglobulin in regulating proteinase activity in normal, ectopic and molar pregnancy.  相似文献   

Adjustments of serum lactate dehydrogenase isoenzymes and their significance in monitoring the treatment in patients with tubercular pyothorax     

Riaz Ahmad  Mumtaz Alam  M. Faisal Siddiqui  Absar-ul Hasnain 《Indian journal of clinical biochemistry : IJCB》2008,23(2):181-185

The adjustments and diagnostic significance of polyacrylamide gel electrophoretic (PAGE) profiles of lactate dehydrogenase isoenzymes (LDH: 1.1.1.27) was evaluated in the sera and pleural fluid of patients with tubercular pyothorax. Sera and pleural fluid samples were randomly collected from 72 and 18 patients respectively at two different timings; first, when patients were admitted to the Hospital and second, after an intensive phase of treatment. Sera of 20 healthy individuals served as control. Our results demonstrate significant differences in sera LDH (sLDH) and pleural fluid LDH (pfLDH) isoenzymes. In patients the order of LDH isoenzyme in sera and pleural fluid followed: LDH−5>−4>−2>−3>−1 and LDH-5>−4>−3>−2>−1 respectively. The ranking of activity levels in control was LDH−2>−1>−3>−5>−4. In the second phase of sampling from 31 patients, values of sLDH isoenzymes showed recovery and resembled profiles of controls. Therefore, the sLDH zymograms of patients can be used as the prognostic marker, since they tend to reach the normal level during recovery signifying the effect of chemotherapy in hospitalized patients. Moreover, according to the present findings on LDH-PAGE profiles, the levels of LDH-5 and-4 rise in pyothorax patients significantly (P<0.05). This elevation along with the rise in total LDH activity may, therefore, be used in the diagnosis and monitoring of tubercular pyothorax.  相似文献   

The English Translation of Arabic Puns in the Holy Quran     

Mohammed H. Al Aqad  Ahmad Arifin Bin Sapar  Mohamad Bin Hussin  Ros Aiza Mohd Mokhtar  Abd Hakim Mohad 《Journal of Intercultural Communication Research》2019,48(3):243-256

The pun is a tricky use of a word or phrase which has very different meanings that are closely interrelated, or of words with the same sound but different meanings. The Pun is a term with a dual meaning: “close” using obvious reference, and “far” using obscure reference. The hidden is usually meant. The close meaning is the sooner that comes to the listener’s mind. However, the speaker targets at the far one yet use the close to hide it. Translating the Quran text always raises several serious challenges in translation; these challenges are due to the different translations of puns and the misinterpretations between the intended meanings of a pun with their basic concepts, which could result in a certain amount of ambiguity. The study examines the Quranic corpus and its three versions of English translations. The study utilizes the typology of Delabastita?s for horizontal puns, Nida’s techniques of dynamic and formal equivalent and Newmark’s translation methods. This research attempts to investigate the semantic meaning of puns in the Quran translation and to define the translation techniques applied in translating the Quranic puns from Arabic into English.  相似文献   

Mixed-methods pre-match cooling improves simulated soccer performance in the heat     

Jeffrey William Frederick Aldous  Bryna Catherine Rose Chrismas  Ibrahim Akubat  Charlotte Anne Stringer  Grant Abt 《European Journal of Sport Science》2019,19(2):156-165

This investigation examined the effects of three pre-match and half-time cooling manoeuvres on physical performance and associated physiological and perceptual responses in eight University soccer players during a non-motorised treadmill based individualised soccer-specific simulation [intermittent soccer performance test (iSPT)] at 30°C. Four randomised experimental trials were completed; following 30-min (pre-match) and 15-min (half-time) cooling manoeuvres via (1) ice slurry ingestion (SLURRY); (2) ice-packs placed on the quadriceps and hamstrings (PACKS); (3) mixed-methods (MM; PACKS and SLURRY concurrently); or no-cooling (CON). In iSPT first half, a moderate increase in total (Mean?±?Standard Deviation: 108?±?57 m, qualitative inference: most likely, Cohen’s d: 0.87, 90%CL: ±0.31), high-speed (56?±?46 m, very likely, 0.68?±?0.38) and variable run (15?±?5 m, very likely, 0.81?±?0.47) distance covered was reported in MM compared with CON. Additionally, pre-match reductions in thermal sensation (–1.0?±?0.5, most likely, –0.91?±?0.36), rectal (–0.6?±?0.1°C, very likely, –0.86?±?0.35) and skin temperature (–1.1?±?0.3°C, very likely, –0.88?±?0.42) continued throughout iSPT first half. Physical performance during iSPT first half was unaltered in SLURRY and PACKS compared to CON. Rectal temperature was moderately increased in SLURRY at 45-min (0.2?±?0.1°C, very likely, 0.67?±?0.36). Condition did not influence any measure in iSPT second half compared to CON. Only MM pre-match cooling augmented physical performance during iSPT first half, likely due to peripheral and central thermoregulatory factors favourably influencing first half iSPT performance. Further practical half-time cooling manoeuvres which enhance second half performance are still required.  相似文献   

The Causal Relationship Between the Efficacy of Training Programs and the Work Environment for Workers with Disabilities     

Abdel Aziz M. Sartawi  Maher M. Abu-Hilal  Ibrahim Qaryouti 《International Journal of Disability, Development & Education》1999,46(1):109-115

The purpose of the study was to test a structural model which involves training variables and work environment variables in the United Arab Emirates and Jordan. Two instruments were used to collect data from people with a disability (n = 113) about their views of the training program and work environment. The Structural Equation Model (SEM) analysis revealed the following results: the factor representing psychological support and suitability of training environment influenced positively the disabled workers' view of their work; the factor representing job selection, trainers, and efficacy of program had a negative effect on the view of the people with disability on their work environment; while job selection had a direct negative effect on how others perceive the disabled person.  相似文献