Book reviews     

Finbarré Fitz Patrick  Nicholas Hawkes  James Cummins  Alison M. Pask  Carol Myers Scotton  R. N. Srivastava 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1978,24(3):423-434

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Transfinite numbers     

S. M. Srivastava 《Resonance》1997,2(3):58-68

In a series of revolutionary articles written during the last quarter of the nineteenth century, the great German mathematician Georg Cantor removed the age-old mistrust of infinity and created an exceptionally beautiful and useful theory of transfinite numbers. This is an introductory article on this topic.  相似文献   

Arts education and the high school dropout problem     

M. Kathleen Thomas  Priyanka Singh  Kristin Klopfenstein 《Journal of Cultural Economics》2015,39(4):327-339

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Stress,Oxidative Injury and Disease     

Kaushal K. Srivastava  Ratan Kumar 《Indian journal of clinical biochemistry : IJCB》2015,30(1):3-10

The living system on earth is largely using oxygen for burning metabolic fuel for energy. The toxicity of oxygen is largely due to the formation of free radicals in living systems. Stress is also responsible for the generation of free radicals. The evidence for the involvement of free radicals and oxidative injury in producing metabolic disturbance, maladjustment and many diseases has been accumulating since long. It is largely believed that the root cause of many chronic diseases is stress induced free radicals and resultant oxidative injury.  相似文献   

Acute Ischemic Stroke is Associated with Increased Serum Levels of Pro-inflammatory Cytokines     

Bhagirath Ramawat  Alvee Saluja  Jayashree Bhatacharjee  Anshuman Srivastava  Rajinder K. Dhamija 《Indian journal of clinical biochemistry : IJCB》2021,36(3):380

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Metabolic Bone Profile of Healthy Adult North Indian Population from Chandigarh Urban Bone Epidemiological Study (CUBES)     

Anshita Aggarwal  Sant Ram  Abhilasha Garg  Rimesh Pal  Anil Bhansali  Priyanka Singh  Sadhna Sharma  J. S. Thakur  Naresh Sachdeva  Sanjay Kumar Bhadada 《Indian journal of clinical biochemistry : IJCB》2021,36(1):67

We aimed to estimate metabolic bone profile in a large cohort of healthy, adult Indian population to generate reference standards of serum calcium, phosphate and alkaline phosphatase (ALP), 25 (OH) Vitamin D and iPTH, and also to find out the prevalence of Vitamin D deficiency in healthy population. Apparently healthy people in the age group of 20–80 years, residing in the union territory of Chandigarh were chosen. Fasting samples for serum calcium, phosphate, albumin, alkaline phosphatase (ALP), 25 (OH) D and iPTH were collected and were processed on the same day. We recruited 930 healthy subjects from different subsectors of Chandigarh. Final analysis was done for 915 subjects. Out of this, 530 (58%) were women and 385 (42%) were men. The study participants were divided into two groups, less than and more than 50 years for the men and pre and post-menopausal for the women. The serum calcium, phosphate, ALP and iPTH were significantly higher in the post-menopausal women compared to the pre-menopausal women. The median plasma 25 (OH) D in men and women was 12.5 ng/mL and 14.3 ng/mL, respectively. 25 (OH) D deficiency was seen in 65.4% of individuals. 25 (OH) D levels co-related negatively with iPTH levels (r = − 0.4, p < 0.0001), and showed an increasing trend with age. We have thus presented metabolic bone profile of healthy, adult north Indian population. These reference values can be used for diagnosis and monitoring of various MBDs. Vitamin D deficiency is still rampant in our population in spite of increasing awareness.  相似文献   

Effect of Resveratrol and Nicotine on PON1 Gene Expression: In Vitro Study     

Nidhi Gupta  Ramesh Kandimalla  Kumari Priyanka  Gagandip Singh  Kiran Dip Gill  Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2014,29(1):69-73

Dietary and lifestyle factors have been shown to have a profound effect on paraoxonase-1 (PON1) activity. Cigarette smoke has been shown to inhibit its mass and activity where as resveratrol has been shown to enhance it. We exposed hepatoma derived cell line (HepG2) to resveratrol and nicotine in varying doses and measured PON1 enzymatic activity and PON1 gene expression. In addition, total protein content of HepG2 cells was also measured. Resveratrol in a dose of 15 μmol/l or above significantly increased the PON1 enzyme activity (p > 0.001) where as nicotine in a dose of 1 μmol/l or higher significantly reduced it (p < 0.05). The resveratrol in this dose also enhanced the PON1 gene expression whereas nicotine decreased it as compared to controls. However, the protein conent of cells was not changed suggesting that they were not cytotoxic in the doses used. Till date the antioxidant vitamins have shown disappointing results against LDL oxidation and cardiovascular protection. However, the effect of resveratrol on PON1 gene expression and activity was significant, suggesting increase in PON1 activity and enhanced gene expression may be its alternative mechanism for offering protection against cardiovascular disease and may be an potential pharmacological agent which can be used for this.  相似文献   

A Case of Sanfillippo’s Disease Correlating Clinical and Biochemical Findings     

Priyanka Datta  Anushre Prasad  Vijetha Shenoy  Shrikiran Hebbar  Suneel C. Mundkur  Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2014,29(4):520-523

The mucopolysaccharidoses (MPSs) are a heterogeneous group of rare inherited disorders caused by deficiency of lysosomal enzyme necessary to break down mucopolysaccharides or glycosaminoglycans (GAGs). We had combined clinical findings and ophthalmological features. Biochemical test for urine glycosaminoglycans was done for confirmation of diagnosis in the patient. The case of Sanfillippo’s disease was characterized by delayed development, hyperactivity with aggressive behaviour. Coarse facial feature, hirsutism and sleep disorder. Urine GAG tests for MPS was positive in the case. Based on clinical findings and biochemical tests for MPS, this case was diagnosed as a type III mucopolysaccharidoses. Urinary GAG’s electrophoresis is an important screening test for MPS suspected cases.  相似文献   

Evaluating the evaluators: (Studies in Teaching and Learning): Maurice Holt — Hodder and Stoughton,London (pp 187). 1981, ISBN 0 340 27245 7 £3.45     

H.S. Srivastava 《International Journal of Educational Development》1982,2(2):201-202

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Healthcare biotechnology in India     

L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(1):201-207

Summary  Biotechnology in India has made great progress in the development of infrastructure, manpower, research and development and manufacturing of biological reagents, biodiagnostics, biotherapeutics, therapeutic and, prophylactic vaccines and biodevices. Many of these indigenous biological reagents, biodiagnostics, therapeutic and prophylactic vaccines and biodevices have been commercialized. Commercially when biotechnology revenue has reached $25 billions in the U.S. alone in 2000 excluding the revenues of biotech companies that were acquired by pharmaceutical companies, India has yet to register a measurable success. The conservative nature and craze of the Indian Industry for marketing imported biotechnology products, lack of Government support, almost non-existing national healthcare system and lack of trained managers for marketing biological and new products seem to be the important factors responsible for poor economic development of biotechnology in India. With the liberalization of Indian economy, more and more imported biotechnology products will enter into the Indian market. The conditions of internal development of biotechnology are not likely to improve in the near future and it is destined to grow only very slowly. Even today biotechnology in India may be called to be in its infancy.  相似文献