LP(a) phenotypes and levels in angiographically proven coronary heart disease patients and controls     

Kalpana Luthra  Suman Vasisht  Shivani Chhabra  K. R. Raju  D. P. Agarwal  S. C. Manchanda  L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》1998,13(1):12-19

Lipoprotein Lp(a) excess has been identified as a powerful predictor of premature atherosclerotic vascular diseases. To evaluate this in a North-Indian population, 130 CAD patients and 130 controls were analyzed. The size of the apo(a) phenotypic isoforms was inversely proportional to Lp(a) concentrations. The mean concentration of Lp(a) in the CAD patients was 42±34 mg/dl whereas in the normal subjects it was much lower, 27±27 mg/dl. 157 subjects out of the total 260 subjects showed plasma levels of >20mg/dl. The frequency of high Lp(a) levels was much higher in patients(73%) than controls (43%). These data suggest (1) that there is heterogeneity of the Lp(a) polymorphism, (2) Higher Lp(a) levels were found in patients than in the controls, (3) Patients showed 1.5 fold increase in Lp(a) levels as compared to the controls. We conclude that low molecular weight apo(a) isoforms are significantly associated with increased risk of CAD in the North-Indian population.  相似文献   

Effect of short term vitamin E supplementation on lipid peroxidation in acute myocardial infarction     

A. P. Jain  A. Mohan  O. P. Gupta  U. N. Jajoo  S. P. Kalantri  L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》1998,13(2):119-122

In view of sufficient body of evidence to substantiate the role of free radical mediated oxidative injury in myocardial infarction (M.I.), the utility of exogenous supplementation with antioxidant substance, vitamin E was studied. Forty patients of acute myocardial infarction were divided into two equal groups, one who received vitamin E and the other who did not. Plasma MDA levels showed a reduction in patients of M.I. who received vitamin E as well as in those who did not, however, the decrease was significantly more in the vitamin E treated subgroup.  相似文献   

Fate of nutrients in human dominated ecosystems     

Priyanka Jamwal 《Resonance》2017,22(3):279-290

Jakkur Lake in the city of Bengaluru covers an approximate area of 55 hectares and primarily receives inflows from the Jakkur sewage treatment plant (STP) and an open storm drain. Jakkur STP discharges an average of 10 million litres of treated water daily (MLD) into the lake. The open drain discharges about 0.5 MLD of raw sewage into the lake. In the absence of environmental flows it becomes critical to assess the impact of nutrient flux on the quality of water, and design cost effective treatment solutions to address the issues of lake water quality. As part of this study, we have assessed the impact of these two primary inflows on the overall water quality of Jakkur Lake. The results have shown that nutrient inflows have led to the increase of chlorophyll-a levels, eventually causing hypereutrophication of Jakkur lake. We have also used simple mass balance approach to assess the contributions of in-lake activities (sedimentation and reaction) on removal of nutrients from the lake. We have concluded that the phosphorus load has to be reduced by approximately 96% from the current levels to prevent algal blooms within Jakkur Lake.  相似文献   

Life and work of Kurt Gödel — A brief sketch     

S. M. Srivastava 《Resonance》2001,6(7):2-3

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The completeness theorem of Gödel     

S. M. Srivastava 《Resonance》2001,6(7):29-41

This is a two-part article giving a brief introduction to mathematical logic. It will culminate in the so-called completeness theorem of Kurt Gödel, which will be proved in the second part.  相似文献   

G?del’s proof
3. Incompleteness theorems     

S M Srivastava 《Resonance》2007,12(5):71-84

After presenting the technique developed by G?del to examine questions about a theory such as Number Theory, Set Theory by the theory itself, we present the surprising Incompleteness Theorems of G?del.  相似文献   

An IAD type framework for Blockchain enabled smart tourism ecosystem     

Janardan Krishna Yadav  Deepika Chandra Verma  Srinivas Jangirala  Shashi Kant Srivastava 《The Journal of High Technology Management Research》2021,32(1):100404

The concept of smart tourism remains fuzzy when it comes to practice because of the lack of clarity on the roles and responsibilities of stakeholders in addition to complex institutional ecosystem that exist within the tourism industry. Further, trust and safety of the data generated due to the advancement of smart tourism in varied institutional arrangements pose huge challenges. Extant literature proposes that the application of decentralized ledger promises possible solutions to most of these problems due to the inherent features of the Blockchain technology. This suggestion raises two practical questions. First, does the sophisticated additional layer adds complexity to its practical application? Second, will the suggested solutions really lead to a win-win for all the stakeholders involved? In this study, we use Ostrom's action arena to examine the exchanges (information, contractual and monetary) between various stakeholders in a BCT enabled smart tourism of a Blockchain enabled tourism industry to answer these two questions.  相似文献   

Impact of CCL2 and Its Receptor CCR2 Gene Polymorphism in North Indian Population: A Comparative Study in Different Ethnic Groups Worldwide     

Vibha Singh  Neena Srivastava  Priyanka Srivastava  Rama Devi Mittal 《Indian journal of clinical biochemistry : IJCB》2013,28(3):259-264

Chemokine are small, inducible pro-inflammatory cytokines involved in many biological processes, such as migration of leukocytes, atherosclerosis, angiogenesis, tumor growth, and metastasis. Chemokine are also known to influence tumor cell’s activity. Specifically, tumor cells express chemokine receptors in a non random manner suggesting a role of chemokine in metastatic destination of tumor cells. The present study was conducted to determine distribution of (Chemokine receptor 2) CCR2 V64I, Chemokine ligand 2 CCL2 I/D, and CCL2 2518 A>G gene polymorphisms in North Indian population and compare with different populations globally. Polymerase chain reaction (PCR)-based analysis was conducted in 200 normal healthy individuals of similar ethnicity. Allelic frequencies in wild type (GG) of CCR2 V64I G>A were 63 % G; CCL2 I/D 42 % II; CCL2 2518 A>G 40.5 % A. The minor variant allele frequency in our population was as follows: 19.5 % for CCR2 V64I, 35.5 % for CCL2 I/D, 35.3 % for CCL2 2518 A>G. We further compared frequency distribution for these genes with various published studies in different ethnicity. Our results suggested that frequency in chemokine genes exhibit distinctive pattern in India that could be attributed to ethnicity variation. This could assist in high-risk screening of human exposed to environmental carcinogens and cancer predisposition in different ethnic groups. Thus, they signify an impact of ethnicity and provide a basis for future epidemiological and clinical studies.  相似文献   

“Proteoglycans—A promising front in cardiovascular research”     

D. K. Srivastava  P. P. Singh 《Indian journal of clinical biochemistry : IJCB》1992,7(1):1-2

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Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease     

Anjali Manocha  L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(1):13-20

The current epidemic affecting Indians is coronary artery disease (CAD), and is currently one of the most common causes of mortality and morbidity in developed and developing countries. The higher rate of CAD in Indians, as compared to people of other ethnic origin, may indicate a possible genetic susceptibility. Hence, Lp(a), an independent genetic risk marker for atherosclerosis and cardiovascular disease assumes great importance. Lp(a), an atherogenic lipoprotein, contains a cholesterol rich LDL particle, one molecule of apolipoprotein B-100 and a unique protein, apolipoprotein (a) which distinguishes it from LDL. Apo(a) is highly polymorphic and an inverse relationship between Lp(a) concentration and apo(a) isoform size has been observed. This is genetically controlled suggesting a functional diversity among the apo(a) isoforms. The LPA gene codes for apo(a) whose genetic heterogeneity is due to variations in its number of kringles. The exact pathogenic mechanism of Lp(a) is still not completely elucidated, but the structural homology of Lp(a) with LDL and plasmin is possibly responsible for its acting as a link between atherosclerosis and thrombosis. Upper limits of normal Lp(a) levels have not been defined for the Indian population. A cut off limit of 20 mg/dL has been suggested while for the Caucasian population it is 30 mg/dL. Though a variety of assays are available for its measurement, standardization of the analytical method is highly complicated as a majority of the methods are affected by the heterogeneity in apo(a) size. No therapeutic drug selectively targets Lp(a) but recently, new modifiers of apo(a) synthesis are being considered.  相似文献