排序方式： 共有85条查询结果，搜索用时 15 毫秒
81.
Ujjawal Sharma Deeksha Pal Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2014,29(3):269-278
Alkaline phosphatase (ALP; E.C.3.I.3.1.) is an ubiquitous membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at basic pH values. Alkaline phosphatase is divided into four isozymes depending upon the site of tissue expression that are Intestinal ALP, Placental ALP, Germ cell ALP and tissue nonspecific alkaline phosphatase or liver/bone/kidney (L/B/K) ALP. The intestinal and placental ALP loci are located near the end of long arm of chromosome 2 and L/B/K ALP is located near the end of the short arm of chromosome 1. Although ALPs are present in many mammalian tissues and have been studied for the last several years still little is known about them. The bone isoenzyme may be involved in mammalian bone calcification and the intestinal isoenzyme is thought to play a role in the transport of phosphate into epithelial cells of the intestine. In this review, we tried to provide an overview about the various forms, structure and functions of alkaline phosphatase with special focus on liver/bone/kidney alkaline phosphatase. 相似文献
82.
Haslinda Abdul HAMID Vahid Hosseinpour SARMADI Vivek PRASAD Rajesh RAMASAMY Azizi MISKON 《Journal of Zhejiang University. Science. B》2022,23(1):42-57
Mesenchymal stem/stromal cell(MSC)-based therapy has been regarded as one of the most revolutionary breakthroughs in the history of modern medicine owing to its myriad of immunoregulatory and regenerative properties.With the rapid progress in the fields of osteo-and musculoskeletal therapies,the demand for MSC-based treatment modalities is becoming increasingly prominent.In this endeavor,researchers around the world have devised new and innovative techniques to support the proliferation of MSCs while minimizing the loss of hallmark features of stem cells.One such example is electromagnetic field(EMF)exposure,which is an alternative approach with promising potential.In this review,we present a critical discourse on the efficiency,practicability,and limitations of some of the relevant methods,with insurmountable evidence backing the implementation of EMF as a feasible strategy for the clinically relevant expansion of MSCs. 相似文献
83.
Avneet Kaur Pooja Negi Veena Sarna Rajendra Prasad Bir S. Chavan Anita Malhotra Gurjit Kaur 《Indian journal of clinical biochemistry : IJCB》2017,32(2):179-185
The present study was undertaken to study the impact of surgical menopause on oxidant and antioxidant status in relation to estrogen levels after 3 months of surgery. Total 130 women who had undergone total hysterectomy (TH) with or without bilateral salpingo-oophorectomy (BSO) were included in this study. The oxidant status was assessed by measuring plasma levels of malondialdehyde and antioxidant status was assessed by measuring superoxide dismutase, catalase, glutathione, glutathione peroxidase, estrogen, and Vitamin A, E and C levels. The malondialdehyde level was significantly increased (p < 0.05) in all women who underwent TH with or without BSO. Significant increased levels of superoxide dismutase were observed in women who underwent TH with BSO. The blood glutathione levels were significantly decreased in women after TH only but significantly increased in women who had undergone TH with BSO. The levels of estrogen, vitamin E and vitamin C were significantly decreased in women who underwent TH with BSO. The catalase, GPx and vitamin A did not differ significantly in all groups. The result suggests that surgical menopause is associated with oxidative stress which reiterates the fact that ovaries retain some function even after menopause. 相似文献
84.
M. Prasad D. Rajarajeswari P. Aruna K. Ramalingam R. Viswakumar Nusrath Fathima Sandeep Kumar Vishwakarma Aleem Ahmed Khan 《Indian journal of clinical biochemistry : IJCB》2022,37(3):335
Essential hypertension (EH) is a multifactorial and complex disease with high rate of incidence and associated co-morbidities. Previous studies do not provide unanimous results for the risk of hypertension and association with Fok I genotype frequency and serum vitamin D levels. Hence, this study was undertaken to determine the status of Fok I vitamin D receptor (VDR) gene polymorphism along with vitamin D levels and blood pressure in patients with EH. Four hundred (200 controls and 200 cases of essential hypertension) participants from general Indian population were enrolled in this study. Peripheral blood samples were collected for genotyping Fok I-VDR gene polymorphism using PCR–RFLP method whereas 25-OH vitamin D levels in serum were quantified using high performance liquid chromatography (HPLC). Significantly reduced 25-OH vitamin D levels were observed in patients with EH (24.04 ± 8.62 vs 50.46 ± 15.46) compared to control subjects (p = 0.0001). Homozygous recessive genotype ‘ff’ frequency was increased by 8.06 fold (CI: 3.71–17.47, p = 0.0001) in patients with EH compared to dominant ‘FF’ genotype frequency. In conclusion, recessive ‘ff’ genotype frequency correlates with reduced serum vitamin D levels and results in significantly increased systolic and diastolic blood pressures leading to predisposition of EH. 相似文献
85.
Prasad Shetty 《Inter-Asia Cultural Studies》2013,14(3):386-409
Abstract This paper addresses the pedagogic and disciplinary challenges posed by the effort to understand urban spatial practices and institutional histories in Bombay/Mumbai, and other postcolonial South Asian cities. Many cities in the region, such as Chandigarh and Dhaka were designed as iconic of the abstract space of the nation‐state. The dominance of the nationalist spatial imagination in the understandings of public space, citizenship, and the metropolitan environment – combined with the functionalist perception of architecture and spatial practice – have resulted in an urban pedagogy that regards the city only as a technological or physical artefact. Architectural education and urban pedagogy is therefore unable to address the diversity of social‐spatial formations in the city, and its political regime of predatory development, tactical negotiation, and blurry urbanism. To better understand this new regime, we require a collaborative urbanism that treats the city as an extra‐curricular space by which we can reconstruct existing institutional frameworks. Drawing on the work of CRIT (Collective Research Initiatives Trust), Mumbai, this papers explores the post‐industrial landscapes of the Mumbai Mill and Port Lands as a case study in two extracurricular research projects, which grew into urban design and community planning interventions in the Mumbai Metropolitan Region, where urban spaces became the arena for re‐imagining the relations between knowledge production, institutional boundaries, and civic activism on which nationalism has imposed a long estrangement. 相似文献