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排序方式: 共有194条查询结果,搜索用时 31 毫秒
101.
Debapriya Bandyopadhyay Haren Baruah Bharat Gupta Shailja Sharma 《Indian journal of clinical biochemistry : IJCB》2012,27(2):164-170
Vascular thrombotic disorders have emerged as a serious threat to our society. Platelet adhesion to fibrinogen, collagen and other platelet activators exposed over the atherosclerotic plaques can trigger platelet signaling events, activate platelets and lead to thrombotic events. Since anticoagulant and thrombolytic treatment strategies are usually associated with serious bleeding complications, preventing platelets adhesion may help to maintain platelets in an inactive state. In this study we tried to find out the effect of Silver nanoparticles, through their interaction with various platelet surface integrins on platelet adhesion on immobilized fibrinogen. Platelets, isolated from anti-coagulated human whole blood sample from healthy donors, were suspended in physiological buffer and each sample was divided into four tubes. In three of them 0.05, 0.5, and 5 μM concentrations of Silver nanoparticles were added, fourth tube served as control. Platelet adhesion on immobilized fibrinogen matrices and integrin mediated cell signaling events were studied in all the four samples. In the present study we show that nanosilver prevent platelet adhesion without conferring any lytic effect on them and effectively prevents integrin-mediated platelet responses in a concentration-dependent manner. 相似文献
102.
103.
V. K. Gupta V. Mallika Yashika Gupta D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》1992,7(1):3-10
Oxygen derived free radicals have been implicated in a number of clinical disorders including atherosclerosis (1), ischemic
heart disease (IHD) (2), post ischemic reperfusion injury (3) and respiratory distress syndrome (4). These radical are generated
by sequential reduction of molecular oxygen; the primary product being superoxide anion (O2
.−) which is subsequently reduced to hydrogen peroxide (H2O2), hydroxy1 radical (OH.) and singlet oxygen (1O2). However the evidence for ODFR induced cell damage in various clinical disorders is still debated and rests largely on free
radical scavenging studies, through electron paramagnetic resonance spectroscopic (EPRS) studies have provided direct evidence
for ODFR generation following coronary artery ligation (5).
By definition, a free radical is an atom, ion or molecule with one or more unpaired electrons (the presence of unpaired electron
in a free radical being represented by a superscribed bold dot-R.) and may be formed as a result of homolytic fission of a covalent bond or by electron transfer reactions, and may have cationic
(NH3
+), anionic (O2
.−) or neutral (NO) characteristics. The most important in vivo source for these radical species have been found to be univalent
biochemical redox reactions involving oxygen. (a) A:B→A.+B. (b) A:+B→A.+B. 相似文献
104.
105.
Discrimination‐Related Stress Effects on the Development of Internalizing Symptoms Among Latino Adolescents 下载免费PDF全文
Selcuk R. Sirin Lauren Rogers‐Sirin Jessica Cressen Taveeshi Gupta Sammy F. Ahmed Alfredo D. Novoa 《Child development》2015,86(3):709-725
This three‐wave longitudinal study of 173 Latino adolescents (M = 16.16 years, SD = 0.65) is designed to understand the role of discrimination‐related stress in mental health trajectories during middle to late adolescence with attention to differences due to immigration status. The results of the growth curve analysis showed that anxious‐depressed, withdrawn‐depressed, and somatic complaints significantly decreased over time. Furthermore, although discrimination‐related stress was found to be significantly related to the trajectories of three types of mental health symptoms, the results revealed that immigration status moderated these relations such that discrimination‐related stress was significantly related to these outcomes for Latino youth whose parents were born in the United States, while this relation was not significant for Latino children of immigrants. 相似文献
106.
107.
Yashika Gupta V. Mallika D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2003,18(1):35-45
High plasma concentration of low-density lipoprotein (LDL) is associated with increased risk of atherosclerosis. Modified
forms of LDL, especially oxidized LDL play a major role in its pathogenesis. This article gives detailed insight into the
kinetics ofin vitro LDL oxidation by copper at different concentrations in normal and high-risk group subjects. Basal level of oxidatively modified
LDL was significantly higher in ischaemic heart disease (IHD) and IHD hyperlipidemic subjects compared to normolipidemic and,
hyperlipidemic control subjects, respectively. Derivatization of amino groups of apo-lipoprotein as monitored by estimating
free amino groups concentration, was significantly higher in high-risk group and established IHD cases. Kinetics of oxidation
was studied with two different concentrations of CuSO4 (2.5 mM and 7.5 mM). thiobarbituric acid reactive substances (TBARS) level increases with time, and up to 95% oxidation was
observed in 8 hr. About 60–65% less free amino groups were observed in native-LDL isolated from IHD patients compared to normal
subjects. Study also showed an increase in two oxidative products studied, 20α-OH-cholesterol and 4-cholesten-3-one with oxidation
time accompanied by corresponding decrease in LDL cholesterol. Increase in oxidative species was more evident in high-risk
group and IHD patient. Basal level of oxidatively modified LDL measured in terms of TBARS was significantly higher in present
study, strongly support that the extent of LDL oxidation monitored as TBARS and FAG level in circulating-LDL could be used
as risk marker for high risk group. 相似文献
108.
Jyoti Titus Suresh Chari Madhur Gupta Nitin Parekh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):168-172
The role of oxidant damage to red cells in sickle cell anaemia has been of interest in recent years. Although, available reports
suggest that sickle cell erythrocytes are susceptible to endogenous free radical mediated oxidant damage there remains discrepancy
in the status of antioxidant enzymes and antioxidant vitamins in these patients. In view of this, 107 cases of sickle cell
anaemia (36 ‘SS’ and 71 ‘AS’ pattern—as confirmed by haemoglobin electrophoresis) were subjected to analysis of malondialdehyde,
ascorbic acid, superoxide dismutase and albumin. The results were compared with 54 age and sex matched healthy controls. The
results indicate a marked increase in lipid peroxidation and superoxide dismutase levels in both ‘SS’ and ‘AS’ types of sickle
cell anaemia as compared to controls. Although no difference was observed in the levels of albumin in these groups the levels
of ascorbic acid were significantly depleted in sickle cell anaemia patients. The results are indicative of enhanced lipid
peroxidation along with imbalance in the pro-oxidant and antioxidant status in patients of sickle cell anaemia. 相似文献
109.
110.
K. P. Mishra Navita Sharma Poonam Soree R. K. Gupta Lilly Ganju S. B. Singh 《Indian journal of clinical biochemistry : IJCB》2016,31(1):81-86
High altitude hypoxia is known to induce an inflammatory response in immune cells. Hypoxia induced inflammatory chemokines may contribute to the development of high altitude pulmonary edema (HAPE) by causing damage to the lung endothelial cells and thereby capillary leakage. In the present study, we were interested to know whether chronic inflammation may contribute to HAPE susceptibility. We examined the serum levels of macrophage inflammatory protein-1α (MIP-1α), monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 in group (1) HAPE Susceptible subjects (n = 20) who had past history of HAPE and group (2) Control (n = 18) consist of subjects who had stayed at high altitude for 2 years without any history of HAPE. The data obtained confirmed that circulating MCP-1, MIP-1α were significantly upregulated in HAPE-S individuals as compared to the controls suggestive of chronic inflammation. However, it is not certain whether chronic inflammation is cause or consequence of previous episode of HAPE. The moderate systemic increase of these inflammatory markers may reflect considerable local inflammation. The existence of enhanced level of inflammatory chemokines found in this study support the hypothesis that subjects with past history of HAPE have higher baseline chronic inflammation which may contribute to HAPE susceptibility. 相似文献