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Ashuma Sachdeva Shashi Seth Anju Huria Khosla Sumit Sachdeva 《Indian journal of clinical biochemistry : IJCB》2005,20(1):131-134
Markers of bone formation in serum include total and bone specific alkaline phosphatase, osteocalcin and Type 1 collagen carboxy
terminal extension peptide. Bone resorption can be assessed by measuring plasma tartarate resistant acid phosphtase and urinary
excretion of collagen degradation products: hydroxyproline, hydroxylysine glycosides and more recently the pyridinium crosslinks
and associated peptides. We compared the excretion of hydroxyproline in women of reproductive age group to those of menopausal
age group and found a significant difference in the two age groups. Urinary hydroxyproline was found to be significantly raised
in post menopausal women. Thus hydroxyproline maybe used as the earliest indicator in the prognostic assessment of postmenopausal
women of their risk of developing osteoporosis and fracture. 相似文献
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Forty cases of head and neck cancer were studied for plasma superoxide dismutase, malondialdehyde and thiol levels and results
were compared with a group of forty normal healthy volunteers. Mean plasma superoxide dismutase activity was not found to
be altered while malondialdehyde concentration was significantly higher when compared with the control group. On the other
hand, mean thiol level was significantly lowered. The data suggests increased level of oxidative stress in patients with head
and neck cancer. 相似文献
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Chatterjee S Dhar S Sengupta B Ghosh A De M Roy S Chakrabarti S 《Indian journal of clinical biochemistry : IJCB》2010,25(3):260-272
Polycyclic aromatic hydrocarbons of tobacco require activation by phase I enzymes, such as cytochrome-P4501A1 (CYP1A1) to
become an ultimate carcinogen, which are subjected to detoxification by phase II enzymes, especially glutathione S-transferases (GSTs). A study was designed to find whether genetic predisposition are risk modifiers of oral pathologies.
The study included 102 cases with Oral Cancers (OCs), 68 cases with nonmalignant pathologies, 100 cases as control group.
GSTM1 null genotype was associated with increased risk of OCs but not with benign pathologies. Deleted GSTT1 was associated
with all pathologies. Both m1m2 and m2m2 polymorphisms of CYP1A1 were associated with oral pathologies. 相似文献
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O. P. Sachdeva Vikas Girdhar S. P. Gulati Harbans Lal 《Indian journal of clinical biochemistry : IJCB》1993,8(1):51-53
Ceruloplasmin levels were estimated in sera of, 40 patients with head and neck cancers. The levels were found to be significantly
higher in patients as compared to the controls. The rise was nearly same in all the patients studied irrespective of the site,
character or histopathology of lesion but was directly proportional to the stage of cancer. A reduction in serum ceruloplasmin
was observed after radiotherapy. 相似文献
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Chaffy Sachdeva Kshema Thakur Aditi Sharma Krishan Kumar Sharma 《Indian journal of clinical biochemistry : IJCB》2018,33(2):132-146
The documentation of lead toxicity (plumbism) dates back to the times when man learnt its various applications. This versatile heavy metal is non-degradable and its ability to get accumulated in the body that goes undiagnosed, makes it a serious environmental health hazard. Lead is now known to affect almost every organ/tissue of the human body. With irreversible effects on neurobiological development of young children and foetus, its toxicity has lasting implications on the human life. Outlining the symptoms, diagnosis and treatment therapy for lead poisoning, the present review elaborates the pathophysiological effects of lead on various organs. This will be of immense help to the health professionals so as to inculcate a better understanding of the lead poisoning which otherwise is asymptomatic. With chelation therapy being the classic path of treatment, new strategies are being explored as additive/adjunct therapy. It is now understood that lead toxicity is completely preventable. In this regard significant efforts are in place in the developed countries whereas much needs to be done in the developing countries. Spreading the awareness amongst the masses by educating them and reducing the usage of lead following stricter industry norms appears to be the only roadmap to prevent lead poisoning. Efforts being undertaken by the Government of India and other organisations are also mentioned. 相似文献