A Methylome‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder          下载免费PDF全文

Edward D. Barker  Esther Walton  Charlotte A.M. Cecil  Richard Rowe  Sara R. Jaffee  Barbara Maughan  Thomas G. O'Connor  Argyris Stringaris  Alan J. Meehan  Wendy McArdle  Caroline L. Relton  Tom R. Gaunt 《Child development》2018,89(5):1839-1855

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).  相似文献   

How to encourage a lifelong learner? The complex relation between learning strategies and assessment in a medical curriculum     

Tamara van Woezik  Jur Koksma  Rob Reuzel  Debbie Jaarsma  Gert Jan van der Wilt 《Assessment & Evaluation in Higher Education》2020,45(4):513-526

Abstract

To foster lifelong learning skills, we need new didactic approaches with aligned assessment methods. Therefore, we investigated whether the outcomes of a project assignment show a different relation to learning strategies than a longitudinal knowledge-based assessment. We studied learning strategies of first year students of medicine and biomedical sciences (n?=?248) and performed hierarchical regression analyses for the learning strategies and grades of the longitudinal knowledge-based test and project assignment. Scores of students, measured with the Motivated Strategies for Learning Questionnaire (Likert scale 1–7), were relatively low for critical thinking (3.53), compared to rehearsal (4.40), elaboration (4.82), organisation (4.69) and metacognitive self-regulation (4.33). Knowledge based tests showed a significant relation to elaboration (p?<?0.01). For the project-based assessment, we did not find a significant relation to any learning strategy (p?=?0.074). Explained variance of the grades was low for all learning strategies (R² < 0.043). Different types of assessment did not discriminate between students with high or low scores on learning strategies associated with lifelong learning. An explanation is that the curriculum is not aligned with assessment, or students do not benefit in terms of grades. We conclude that, if assessment is to drive lifelong learning skills, this is not self-evident.  相似文献   

Resilience in higher education students: a scoping review     

Margo. L. Brewer  Gisela van Kessel  Brooke Sanderson  Fiona Naumann  Murray Lane  Alan Reubenson 《高等教育研究与发展》2019,38(6):1105-1120

ABSTRACT

The health, wellbeing and employability of university students are key considerations within higher education. In response, interest in student resilience is on the rise. Reviews of contemporary resilience literature highlight both conceptual and methodological weaknesses, issues which hamper attempts to design effective resilience interventions. To inform the design of a student resilience program, to be piloted at three Australian universities, a scoping review of resilience specific to the higher education context was undertaken. Searches of three electronic databases (PsychINFO, CINAHL and ProQuest) were conducted. Seventy-two peer-reviewed articles published between 2007 and 2017 were included in the review. While the review reaffirms the conceptual and methodological issues found in previous resilience research, it provides a useful critique of key issues in relation to university student resilience and interventions to enhance students’ resilience. Recommendations for educators and researchers are provided.  相似文献   

Open Source software in US higher education: Reality or illusion?     

Shahron Williams van Rooij 《Education and Information Technologies》2007,12(4):191-209

As institutions of Higher Education try to balance limited resources with the rising costs of technology, some institutions are turning to Open Source software for campus-wide applications such as course management systems and portals. The assumption is that Open Source will provide the flexibility to build pedagogically sound learning environments while increasing technology efficiencies. This paper outlines the current state of Open Source software deployment in US Higher Education based on a survey of 772 Chief Academic Officers and Chief Information Officers conducted in 2006. The results indicate that Carnegie classification is a critical differentiator of awareness, adoption, and perceptions of Open Source software applications, with perceived cost of ownership being the key driver of Open Source adoption. Moreover, the study shows that institutions have made little progress in the development of polices and procedures for Open Source regulatory compliance and security. The study serves as a baseline for future research into the conditions for successful use of Open Source for supporting integrated learning environments that deliver campus-wide efficiencies.

Shahron Williams van RooijEmail:

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Shahron Williams van Rooij   is Assistant Professor of Instructional Technology at George Mason University with a focus on the university’s e-Learning Certificate Program. She holds a Ph.D. in Quantitative Methods in the Social Sciences from the City University of New York and has just completed a second doctorate in Instructional Technology and Software Information Systems at George Mason University. As a Certified Distance Education Professional (C.D.E.P.) credentialed by Texas A&M University, she is a frequent speaker on the development of Web-based education and has published in a variety of journals such as the WebNet Journal, the Journal of Interactive Learning Research, the Journal of Modern Business, the Marketing Research Review and the Journal of Research on Technology in Education. Prior to joining GMU, she was the Director of Marketing at Datatel, Inc., in Fairfax, VA, where she facilitated the engineering of new e-learning technology solutions.  相似文献   

Development of decision making in school-aged children and adolescents: evidence from heart rate and skin conductance analysis   总被引：2，自引：1，他引：1  

Crone EA  van der Molen MW 《Child development》2007,78(4):1288-1301

Age differences in decision making indicate that children fail to anticipate outcomes of their decisions. Using heart rate and skin conductance analyses, we tested whether developmental changes in decision making are associated with (a) a failure to process outcomes of decisions, or (b) a failure to anticipate future outcomes of decisions. Children aged 8-10, 12-14, and 16-18 years performed the Hungry Donkey task, a child version of the Iowa Gambling Task, while heart rate and skin conductance activity were continuously recorded. Children aged 16-18 learned to make advantageous choices over task blocks faster than the two younger age groups. Age differences were present for anticipation-related autonomic activity but not outcome-related autonomic activity. The results are interpreted vis-à-vis models of prefrontal cortex maturation.  相似文献   

Investigation of potential gender bias in the peer review system at Reproduction     

Marie Biolková  Tom Moore  Karen Schindler  Karl Swann  Andy Vail  Lindsay Flook  Helen Dick  Greg Fitzharris  Christopher A. Price  Norah Spears 《Learned Publishing》2023,36(1):25-30

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Ark of civilisation: refugee scholars and Oxford University, 1930–1945, edited by Sally Crawford,Katharina Ulmschneider,and Jaś Elsner     

Tomás Irish 《History of education》2019,48(3):424-426

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The directional links between students’ academic motivation and social integration during the first year of higher education     

Noyens  Dorien  Donche  Vincent  Coertjens  Liesje  van Daal  Tine  Van Petegem  Peter 《European Journal of Psychology of Education - EJPE》2019,34(1):67-86

European Journal of Psychology of Education - Previous theoretical research proposed a link between students’ academic motivation and students’ experiences of social integration, but...  相似文献   

“None of the Kings on Earth is Their Equal in ʿaṣabiyya”: The Mongols in Ibn Khaldūn's Works     

Josephine van den Bent 《Al-Masaq: Islam & the Medieval Mediterranean》2016,28(2):171-186

The rise of the Mongol empire was a shock to the Arab world and led many Arab authors to describe these conquerors in decidedly negative terms. The great historian Ibn Khaldūn also discusses the Mongols' rise and their conquests. As a nomadic people they challenged and defeated sedentary populations and founded their own dynasties. Consequently, the Mongol conquests perfectly fit Ibn Khaldūn's theories on ?a?abiyya – which is superior in nomadic groups – and the rise and fall of dynasties. For the Maghrebi historian, the rise of the Mongols was a natural step in the course of history. This consequently colours his view of the Mongols and affects the way he portrays them, especially regarding the themes of violence and religion – recurring themes in many contemporary works dealing with the Mongols – and in his depiction of the Turco-Mongolian conqueror Timur, who is presented in a more favourable light by Ibn Khaldūn than he is in many contemporary works.  相似文献   

Skating start propulsion: three-dimensional kinematic analysis of elite male and female ice hockey players     

Jaymee R. Shell  Shawn M. K. Robbins  Philippe C. Dixon  Philippe J. Renaud  René A. Turcotte  Tom Wu 《Sports biomechanics / International Society of Biomechanics in Sports》2017,16(3):313-324

The forward skating start is a fundamental skill for male and female ice hockey players. However, performance differences by athlete’s sex cannot be fully explained by physiological variables; hence, other factors such as skating technique warrant examination. Therefore, the purpose of this study was to evaluate the body movement kinematics of ice hockey skating starts between elite male and female ice hockey participants. Male (n = 9) and female (n = 10) elite ice hockey players performed five forward skating start accelerations. An 18-camera motion capture system placed on the arena ice surface captured full-body kinematics during the first seven skating start steps within 15 meters. Males’ maximum skating speeds were greater than females. Skating technique sex differences were noted: in particular, females presented ~10° lower hip abduction throughout skating stance as well as ~10° greater knee extension at initial ice stance contact, conspicuously followed by a brief cessation in knee extension at the moment of ice contact, not evident in male skaters. Further study is warranted to explain why these skating technique differences exist in relation to factors such as differences in training, equipment, performance level, and anthropometrics.  相似文献