Should we open the reviewing process     

Vladimir Mr&#x;a 《Food Technology and Biotechnology》2021,59(1):1

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Antipsychotics-induced hyperprolactinemia and screening for macroprolactin     

Nedjeljka Ruljancic  Ana Bakliza  Sandra Vuk Pisk  Natko Geres  Katarina Matic  Ena Ivezic  Vladimir Grosic  Igor Filipcic 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(1)

IntroductionHigh prolactin (PRL) concentrations are found in laboratory test results of patients on majority of antipsychotic drugs. Prevalence rates and degrees of severity of hyperprolactinemia (HPRL) based on PRL concentration may depend on the presence of macroprolactin in the serum. The aim of the study was to investigate the difference between PRL concentrations before and after precipitation of macroprolactin and to examine if there were any changes in the categorization of HPRL between samples prior and after precipitation.Materials and methodsTotal of 98 female patients (median age 33; range 19-47 years) diagnosed with a psychotic disorder, proscribed antipsychotic drugs, and with HPRL were included. Total PRL concentration and PRL concentration after macroprolactin precipitation with polyethylene glycol (postPEG-PRL) were determined by the chemiluminometric method on the Beckman Coulter Access2 analyser.ResultsTotal PRL concentrations (median 1471; IQC: 1064-2016 mlU/L) and postPEG-PRL concentrations (median 1453; IQC: 979-1955 mlU/L) were significantly correlated using intraclass correlation coefficient for single measurements (mean estimation 0.96; 95%CI 0.93-0.97) and average measurement (mean estimation 0.98; 95%CI 0.96-0.99), and all investigated female patient had HPRL according to PRL and postPEG-PRL concentration. The median PRL recovery following PEG precipitation was 95; IQC: 90-100%. There was substantial agreement (kappa test = 0.859, 95% CI: 0.764-0.953) between the categories of HPRL severity based on total PRL concentrations and postPEG-PRL concentrations.ConclusionThe study demonstrated that HPRL was present in all subjects using the reference interval for total PRL concentration and postPEG-PRL concentration with no significant impact of macroprolactin presence in the serum on the categorization of patients according to severity of HPRL.  相似文献   

The Financial Situation of the Higher Education System of the Russian Federation     

Vladimir Aleksandrovich Galanov 《Higher Education in Europe》1997,22(2):137-143

For a number of reasons, higher education in the Russian Federation has been able to benefit from a more stable financial situation than have most of the other “socio‐cultural areas” in Russia. It has nevertheless been severely affected by the problems besetting the other sectors of the Russian economy, most of them linked to the rigours of transition to a market economy. The situation will improve as the Russian economy as a whole improves and as higher education in Russia not only becomes more market‐oriented and quality conscious but adopts specific administrative measures designed to ensure efficiency.  相似文献   

Suggestopedy: A valid practice based on unremarkable theory     

Vladimir Fiodorovitch Morgun 《Prospects》1980,10(4):403-414

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Estimation fusion of nonlinear cost functions with application to multisensory Kalman filtering     

Il Young Song  Vladimir Shin  Seokhyoung Lee  Won Choi 《Journal of The Franklin Institute》2014

This paper focuses on four fusion algorithms for the estimation of nonlinear cost function (NCF) in a multisensory environment. In multisensory filtering and control problems, NCF represents a nonlinear multivariate functional of state variables, which can indicate useful information of the target systems for automatic control. To estimate the NCF using multisensory information, we propose one centralized and three decentralized estimation fusion algorithms. For multivariate polynomial NCFs, we propose a simple closed-form computation procedure. For general NCFs, the most popular procedure for the evaluation of their estimates is based on the unscented transformation. The effectiveness and estimation accuracy of the proposed fusion algorithms are demonstrated with theoretical and numerical examples.  相似文献   

Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation     

Leble V  Lima R  Dias R  Fernandes C  Ishikawa T  Imai Y  Yamaguchi T 《Biomicrofluidics》2011,5(4):44120-4412015

In microcirculation, red blood cells (RBCs) flowing through bifurcations may deform considerably due to combination of different phenomena that happen at the micro-scale level, such as: attraction effect, high shear, and extensional stress, all of which may influence the rheological properties and flow behavior of blood. Thus, it is important to investigate in detail the behavior of blood flow occurring at both bifurcations and confluences. In the present paper, by using a micro-PTV system, we investigated the variations of velocity profiles of two working fluids flowing through diverging and converging bifurcations, human red blood cells suspended in dextran 40 with about 14% of hematocrit level (14 Hct) and pure water seeded with fluorescent trace particles. All the measurements were performed in the center plane of rectangular microchannels using a constant flow rate of about 3.0 × 10⁻¹² m³/s. Moreover, the experimental data was compared with numerical results obtained for Newtonian incompressible fluid. The behavior of RBCs was asymmetric at the divergent and convergent side of the geometry, whereas the velocities of tracer particles suspended in pure water were symmetric and well described by numerical simulation. The formation of a red cell-depleted zone immediately downstream of the apex of the converging bifurcation was observed and its effect on velocity profiles of RBCs flow has been investigated. Conversely, a cell-depleted region was not formed around the apex of the diverging bifurcation and as a result the adhesion of RBCs to the wall surface was enhanced in this region.  相似文献   

THE MEANING AND IMPORTANCE OF CULTURALLY DETERMINED IMPLICIT VALUES FOR THE INTERNATIONALIZATION OF EDUCATION     

Mirjana Krizmanić  Vladimir Kolesarić 《Higher Education in Europe》1991,16(2):46-60

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Will it be possible to integrate young people in a society undergoing transformation?     

Sergey Aleshenok  Vladimir Chuprov  Julia Zubok 《Prospects》1995,25(3):439-449

Ph.D. Senior researcher at the Scientific Research Centre of the Institute of Youth (Moscow). Specialist in studies of youth policies and civil society. Author ofInternational experience of public support of the youth organizations (1995) andSituation and prospects of social voluntary action in Russia (1995).  相似文献   

Auditory dominance and its change in the course of development     

Robinson CW  Sloutsky VM 《Child development》2004,75(5):1387-1401

Young children often have a preference for auditory input, with auditory input often overshadowing visual input. The current research investigated the developmental trajectory and factors underlying these effects with 137 infants, 132 four-year-olds, and 89 adults. Auditory preference reverses with age: Infants demonstrated an auditory preference, 4-year-olds switched between auditory and visual preference, and adults demonstrated a visual preference. Furthermore, younger participants were likely to process stimuli only in the preferred modality, thus exhibiting modality dominance, whereas adults processed stimuli in both modalities. Finally, younger participants ably processed stimuli presented to the nonpreferred modality when presented in isolation, indicating that auditory and visual stimuli may be competing for attention early in development. Underlying factors and broader implications of these findings are discussed.  相似文献   

Is a picture worth a thousand words? The flexible nature of modality dominance in young children     

Napolitano AC  Sloutsky VM 《Child development》2004,75(6):1850-1870

When presented simultaneously with equally discriminable, but unfamiliar, visual and auditory stimuli, 4-year-olds exhibited auditory dominance, processing only auditory information (Sloutsky & Napolitano, 2003). The current study examined factors underlying auditory dominance. In 6 experiments, 4-year-olds (N=181) were presented with auditory and visual compounds in which (a) the complexity and familiarity of stimuli were systematically varied (Experiments 1-5) and (b) participants were explicitly instructed to attend to a particular modality (Experiment 6). Results indicate that auditory dominance is a special case of flexible modality dominance, which may stem from automatic pulls on attention. Theoretical implications of these results for understanding the development of attention and cross-modal processing, as well as linguistic and conceptual development, are discussed.  相似文献