Interrelationship Between Procalcitonin and Organ Failure in Sepsis     

Dimple Anand  Sabari Das  Sumit Ray  Seema Bhargava  Lalit Mohan Srivastava 《Indian journal of clinical biochemistry : IJCB》2014,29(1):93-96

Sepsis suffers from lack of specific clinical symptoms which contribute to one of the major causes of mortality. In the present study, our aim was to evaluate the role of a recent biomarker Procalcitonin (PCT) in predicting organ dysfunction. 71 patients admitted with sepsis were included in the study. PCT levels were measured at 0, 24, 72 h and 7th day and sequential organ failure assessment score (SOFA) scores were calculated. PCT levels significantly decreased (p < 0.001) in 89.3 % of surviving patients, whereas, in 60 % non surviving patients the PCT level increased significantly (p < 0.001). A significant positive correlation between PCT and SOFA score was observed in survivors at each hour. These observations indicate that PCT concentration is significantly associated with severity of multi organ dysfunction and also helps in determining the prognosis of septic patients.  相似文献   

Validation Protocol: First Step of a Lean-Total Quality Management Principle in a New Laboratory Set-up in a Tertiary Care Hospital in India     

Das B 《Indian journal of clinical biochemistry : IJCB》2011,26(3):235-243

Method validation is pursued as the first step in establishing Lean-Total Quality Management in a new clinical laboratory, in order to eliminate error in test results. Validation of all the new tests were done (with particular reference to alkaline phosphatase) by verifying reference intervals, analytical accuracy and precision, inter-assay and intra-assay variations, analytical sensitivity, limit of detection, linearity and reportable range, i.e. (i) Analytical measurement range (AMR) and (ii) Clinically reportable range (CRR). Our obtained reference range was within that of the manufacturer’s and showed high degree of analytical accuracy between two laboratories (r ² = 0.99). Precision was comparable with the manufacturer’s claim with inter-assay variation CV 1.04% and intra-assay variation CV 1.54%. Lowest limit of detection was 1.0324 ± 0.007 with CV 0.34%. AMR was also verified with CV 1.26 and 0.69%, for level 1 and level 2 control sera, respectively. The assay was linear with different dilutions. Lean concept was also verified with high recovery percentage. Validation ensures that accurate and precise results are reported in a clinically relevant turn around time.  相似文献   

Effects of Long Term Ethanol Consumption on Cell Death in Liver     

Das SK  Mukherjee S  Vasudevan DM 《Indian journal of clinical biochemistry : IJCB》2011,26(1):84-87

Apoptosis plays an important role in cellular homeostasis. In this study we have investigated whether apoptosis is a contributory factor to alcohol induced liver damage. Long term ethanol (1.6 g/kg body weight/day) exposure augmented liver apoptosis as reflected by high frequency of positive TUNEL staining nuclei and by an increased activity of caspase-3 and -8. Our study provides evidence that long-term ethanol consumption triggers apoptotic process in the liver.  相似文献   

Attitudes of secondary school teachers towards inclusive education in New Delhi,India     

Nisha Bhatnagar  Ajay Das 《Journal of Research in Special Educational Needs》2014,14(4):255-263

This study was undertaken to determine the attitudes of secondary regular schoolteachers towards the inclusion of students with disabilities in New Delhi. A total of 470 teachers, working in schools managed by a private organisation in Delhi, returned the completed survey. A two‐part questionnaire was used in this study. Part one gathered information relating to personal and professional characteristics of the teachers. Part two was a 16‐item Likert scale titled, Attitudes towards Inclusive Education Scale. The major finding of the study was that the teachers in Delhi had positive attitudes towards the inclusion of students with special needs. This study also indicated that the teachers who were more positive about inclusive education were male, younger teachers (less than 40 years of age), less experienced (less than 10 years) and had postgraduate qualifications. In addition, the teachers who had a contact with a person with a disability and those who did not have a focus on disability during their preservice teacher education programmes were more positive towards inclusive education.  相似文献   

Classroom     

Santanu Das  N. Kumar 《Resonance》2014,19(8):764-774

  相似文献   

Special Issue: Audiences: A Cross-Generational Dialogue     

Ranjana Das 《The Communication Review》2013,16(1-2):3-8

  相似文献   

Reading different orthographies: an fMRI study of phrase reading in Hindi–English bilinguals     

Uttam Kumar  Tanusree Das  Raju S. Bapi  Prakash Padakannaya  R. Malatesha Joshi  Nandini C. Singh 《Reading and writing》2010,23(2):239-255

  相似文献   

General relativity and the accelerated expansion of the universe     

Patrick?Das?GuptaEmail author 《Resonance》2012,17(3):254-273

The 2011 Nobel Prize in Physics has been awarded to S Perlmutter, A Riess and B Schmidt for their path-breaking discovery that the rate of expansion of the universe is increasing with time. The trio used Type Ia supernovae (SNe Ia) as standard candles to estimate their luminositydistances. To appreciate some of the far-reaching implications of their work, I have provided an elementary exposition of the general theory of relativity, accelerated expansion of the universe, luminosity-distance, SNe Ia and the cosmological constant problem.  相似文献   

Plane curves of some geometrical significance and associated differential equations     

Jyoti Das 《Resonance》2010,15(6):573-580

Loci of points in the Euclidean plane are determined from prescribed relations of the points with given points, and/or, lines. The dependence of these relations on parameters lead to the diffrential equations representing the family of loci under concern. Incidentally most of the diffrential equations thus obtained are nonlinear ordinary diffrential equations.  相似文献   

Relations of Preschoolers' Social Acceptance to Peer Ratings and Self-Perceptions     

Rina Das  Thomas J. Berndt 《Early education and development》1992,3(3):223-231

To examine the relations of preschoolers' social acceptance to peer ratings and self-perceptions, 53 preschoolers were asked to rate how much they liked or disliked their peers and to justify these ratings. Preschoolers also rated their peers' aggressive, prosocial, and sociable behavior. Finally, they completed a pictorial self-perception scale that assessed their views of their physical competence and their relationships with mother and with peers. Children who were better liked by peers were rated as more prosocial, more sociable, and less aggressive than less liked children. Preschoolers often reported liking certain peers because they perceived that those peers liked them; they often reported disliking certain peers because they perceived those peers as aggressive. In contrast to findings with older children, preschoolers' social acceptance was not significantly related to any aspect of their self-perceptions. The results provide evidence for the validity of peer ratings by preschool-age children and bring up issues related to the development and assessment of self-perceptions among preschoolers.  相似文献