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Abstract

Runners have increased numbers of neutrophils in the airways at rest and after exercise compared with sedentary individuals. The aim of this study was to determine whether Mediterranean seasonal changes in temperature, humidity or airborne pollutants affect the airway cells of runners training outdoors in an urban environment. In nine male amateur runners, cell composition, apoptosis, and inflammatory mediators were measured in induced sputum collected at rest (baseline) and the morning after races held in the fall (21 km), winter (12 km), and summer (10 km). Concentrations of air pollutants were below the alert threshold at all times. Neutrophil differential counts tended to increase after all races (P = 0.055). Apoptosis of neutrophils increased with ozone (P < 0.005) and particulate matter <10 μm (PM10) (P < 0.05) exposure. Bronchial epithelial cell counts were low at all times and weakly correlated with ozone and PM10 concentrations. Apoptotic bronchial epithelial cells increased after all races (P < 0.05). Inflammatory mediators in induced sputum were low at baseline and after the races, and correlated with neutrophil differential counts only at rest. In conclusion, apoptosis of airway cells in runners appears to be affected by both exercise and environmental conditions. Apoptosis of neutrophils increased with exposure to environmental pollutants while apoptosis of bronchial epithelial cells increased after intense exercise. Since no relationship was observed between neutrophil counts and inflammatory mediators 20 h after races, airways inflammation at this time point appears blunted in healthy runners and little affected by exposure to mild seasonal changes and airborne pollutants.  相似文献   
23.
A common missense mutation (1470T > A) in gene SLC16A1 responsible for an amino acid substitution in protein MCT1 has been associated with differential lactate transport and hence, differences in physical performance and muscle injuries in relation to physical exercise. This study describes, for the first time, the worldwide variation of MCT1 variant 1470T > A at an intra- and inter-continental level. Two thousand five hundred and four individual genotypes of 26 populations clustered in 5 population groups have been analysed with data downloaded from the public database 1000 Genomes Phase 3 Browser. Several parameters of population differentiation and structure have been explored as well as selection signatures in the whole gene. Allele T, the common variant, shows extremely high values in Sub-Saharan African groups (frequencies 86–91%) as compared with the remaining world regions (69–49%). TT genotype also predominates in African groups, showing significant differences with the rest of world populations. In view of the evidence that the TT genotype is associated with clinical implications and a better predisposition to sprint/power performances, we suggest that the high presence of the TT genotype in African populations should be taken into account in future association studies at both medical and sports fields.  相似文献   
24.
This article explores the relationship between children's knowledge and perceptions about their rights and subjective well-being (SWB) in a sample of 8-, 10- and 12-year-olds in 18 countries, taking account of gender differences. Children's knowledge and perceptions about their rights were analysed considering whether they reported that they knew their rights, whether they had heard about the UN Convention on the Rights of the Child (CRC) and whether they thought that, in their country, adults respected their rights. To explore SWB, a modified version of the Student's Life Satisfaction Scale, adapted by the Children's Worlds project, was used. Children reporting that they knew their rights, knew about the CRC, or thought that in their country adults respected their rights demonstrated significantly higher SWB scores than those reporting otherwise in the 18 countries. The effects of perceiving that adults in general respected children's rights in their own country on SWB were much more important than the knowledge of children's rights or the knowledge of the CRC. Results provide useful indications on how to promote children's well-being in public policies, including in education, through the promotion of their rights.  相似文献   
25.
This article describes the development of a Comenius project focused on school self-evaluation involving partners from four European countries and resulting in an international course which took place in Italy. The planning, the implementation and the evaluation of the course are presented, clarifying the difficulties and the constraints met and the solutions adopted, the weak and the strong aspects as they emerged from the evaluation undertaken, as well as some recommendations for improvement. In conclusion, some general observations are made on the project as a whole.  相似文献   
26.
Higher Education - This study, which aims to investigate some potential effects derived from the adoption of performance-oriented funding in the higher education system, is focused on competitive...  相似文献   
27.
En formato coloquial y de entrevista las autoras nos cuentan su proceso de reflexión didáctica para lograr una innovación general del modo y perspectiva para enseñar el lenguaje escrito, pasando desde un método tradicional basado en la enseñanza de un repertorio fonético y gráfico, a una enseñanza basada en la interacción y comprensión del propio proceso de escribir y leer, que resultó estar también perfectamente al alcance de los niños con necesidades educativas especiales.  相似文献   
28.
Resumen

Este estudio identifica las estrategias de los profesores cuando se enfrentan a incidentes críticos (IC) en contextos de alta diversidad sociocultural, reconociendo el peso de la identidad y de las emociones en la toma de decisiones, así como la efectividad de las mismas para promover cambios en las prácticas docentes. En el estudio de naturaleza cualitativa, fueron entrevistados 23 profesores universitarios. Los resultados indican que las emociones asociadas a un IC, generan una situación de desequilibrio que puede obstaculizar la actividad cuando son de naturaleza negativa. Al mismo tiempo, en estas situaciones es posible la revisión y reconstrucción de la propia identidad docente. En cuanto a las estrategias empleadas por los docentes ante los IC, éstas fueron mayoritariamente inmediatas e incidieron en aspectos muy puntuales, lo que derivó en actuaciones reactivas y poco eficaces. Pese a ello, la mayoría de los profesores no modificaron sus posiciones iniciales y fueron excepcionales las situaciones en las que el despliegue de estrategias y la reflexión posterior a un determinado IC permitió cambios estructurales que impactaron en alguna dimensión de la identidad del profesor como sus emociones y prácticas.  相似文献   
29.
An increasing number of scientific publications have provided data from different countries suggesting subjective well-being (SWB) continuously decreases during adolescence. A review of these publications reveals authors have used dissimilar scales in diverse countries. Using data from the international Children's Worlds project (N = 48,040), involving 15 countries, a comparative analysis was performed to determine how mean scores evolve with different SWB scales from the age of 8 onwards. The results support the hypothesis that the tendency of SWB to decrease with age starts at around 10 years of age in most countries, while also confirming that different psychometric scales display different levels of sensitivity to diverse sociocultural contexts and more than one should be used in any research on children and adolescents’ SWB.  相似文献   
30.
ABSTRACT

This study examined the age-specific development of vertical jump height, straight and change-of-direction (COD) speed, and COD deficit in one-hundred and eighty-two elite soccer players from different age-categories (U15, U17, U20, and Senior). All participants were players of two distinct clubs and were undertaking different training routines, as planned by their technical staff members. For this purpose, the soccer players performed: (1) squat and countermovement jumps; (2) a maximal 20-m linear sprint speed test, and (3) the Zigzag COD test. The magnitude-based inference approach and standardized differences were used to compare the age-groups. Sprint speed at longer distances (20-m) increased progressively across the age-ranges. In contrast, speed and acceleration performances at shorter distances (5-m) were better in U15 than in the other age-categories. The COD speed did not change throughout the younger categories but presented a meaningful decrease in the Senior category. Surprisingly, despite the progressive increase in volume and intensity of neuromuscular training from younger to older categories, the COD deficit presented a gradual increase across the age-groups. It is possible that simple modulation of the strength-power training program during the maturation process is not sufficient to produce faster adult players with enhanced ability to change direction. Therefore, coaches are strongly encouraged to implement specific COD training practices to tolerate braking at increasing running speeds and appropriate volume and intensity of soccer specific training throughout the players’ specialization process.  相似文献   
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