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81.
European Journal of Psychology of Education - This study aimed to understand how children reflect about learning, report their regulation of learning activity, and develop their performance in...  相似文献   
82.
Stromal cells in the tumor microenvironment play a key role in the metastatic properties of a tumor. It is recognized that cancer-associated fibroblasts (CAFs) and endothelial cells secrete factors capable of influencing tumor cell migration into the blood or lymphatic vessels. We developed a microfluidic device that can be used to image the interactions between stromal cells and tumor cell spheroids in a three dimensional (3D) microenvironment while enabling external control of interstitial flow at an interface, which supports endothelial cells. The apparatus couples a 200-μm channel with a semicircular well to mimic the interface of a blood vessel with the stroma, and the design allows for visualization of the interactions of interstitial flow, endothelial cells, leukocytes, and fibroblasts with the tumor cells. We observed that normal tissue-associated fibroblasts (NAFs) contribute to the “single file” pattern of migration of tumor cells from the spheroid in the 3D microenvironment. In contrast, CAFs induce a rapid dispersion of tumor cells out of the spheroid with migration into the 3D matrix. Moreover, treatment of tumor spheroid cultures with the chemokine CXCL12 mimics the effect of the CAFs, resulting in similar patterns of dispersal of the tumor cells from the spheroid. Conversely, addition of CXCL12 to co-cultures of NAFs with tumor spheroids did not mimic the effects observed with CAF co-cultures, suggesting that NAFs produce factors that stabilize the tumor spheroids to reduce their migration in response to CXCL12.  相似文献   
83.
For policy-makers and managers of research organizations, improvement in performance is a constant objective. The potential presence of returns to scope of fields of research could influence decisions in planning the fields of activity of the research organization and the spatial positioning of its researchers in function of their specializations. We investigate the possible presence of returns to scope and the relation between scope of fields in an organization and intensity of interdisciplinary collaboration. The results, from analyzing the scientific collaborations of Italian university researchers over the years 2004–2008, seem to indicate that in general the scope of the research fields has no impact on the productivity of research or the intensity of interdisciplinary collaboration.  相似文献   
84.
This work maps and analyses cross-citations in the areas of Biology, Mathematics, Physics and Medicine in the English version of Wikipedia, which are represented as an undirected complex network where the entries correspond to nodes and the citations among the entries are mapped as edges. We found a high value of clustering coefficient for the areas of Biology and Medicine, and a small value for Mathematics and Physics. The topological organization is also different for each network, including a modular structure for Biology and Medicine, a sparse structure for Mathematics and a dense core for Physics. The networks have degree distributions that can be approximated by a power-law with a cut-off. The assortativity of the isolated networks has also been investigated and the results indicate distinct patterns for each subject. We estimated the betweenness centrality of each node considering the full Wikipedia network, which contains the nodes of the four subjects and the edges between them. In addition, the average shortest path length between the subjects revealed a close relationship between the subjects of Biology and Physics, and also between Medicine and Physics. Our results indicate that the analysis of the full Wikipedia network cannot predict the behavior of the isolated categories since their properties can be very different from those observed in the full network.  相似文献   
85.
Recent developments in digital scholarship point out that academic practices supported by technologies may not only be transformed through the obvious process of digitization, but also renovated through distributed knowledge networks that digital technologies enable, and the practices of openness that such networks develop. Yet, this apparent freedom for individuals to re-invent the logic of academic practice comes at a price, as it tends to clash with the conventions of a rather conservative academic world. In other words, it may still take some time until academia and the participatory web can fully identify themselves with one another as spaces of ‘public intellectualism’, scholarly debate and engagement. Through a narrative inquiry approach, this research explores how academic researchers engaged in digital scholarship practices perceive the effects of their activity on their professional identity. Pierre Bourdieu’s concept of habitus is used as a theoretical construct and method to capture and understand the professional trajectories of the research participants and the significance of their digital practices on their perceived academic identity. The research suggests that academics engaged in digital practices experience a disjointed sense of identity. The findings presented in this article illustrate how experiences with and on the participatory web inform a new habitus which is at odds with a habitus that is traditionally expected in academia.  相似文献   
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87.
The aim of this study was to compare the effects of 11 weeks of low-volume resistance training (LVRT) and high-volume resistance training (HVRT) on muscle strength, muscle thickness (MT), and postprandial lipaemia (PPL) in postmenopausal women. Thirty-six healthy and untrained postmenopausal women (age, 58.9 ± 5.8 years; 68.6 ± 10.3 kg; and BMI, 26.9 ± 4.8 kg · m?2) participated in resistance training 3× per week for 11 weeks (HVRT = 12; LVRT = 13; and control group = 11). Biochemical variables, both pretraining and post-training, were evaluated 16 h after the administration of an oral fat tolerance test (OFTT) and metabolic variable during [energy expenditure (EE)] and after training session [excess postexercise oxygen consumption (EPOC)]. Muscle strength (1 RM) and MT were also calculated, and no significant differences were observed between the groups for PPL (mmol · L?1 per 5 h) as measured by glucose, high-density lipoprotein, low-density lipoprotein, and total cholesterol. EE total (EE + EPOC; 6.12 ± 1.21 MJ vs. 2.26 ± 0.85 MJ), resting fat oxidation (5.52 ± 1.69 g · h?1 vs. 4.11 ± 1.12 g · h?1); MT (vastus medialis, 21.4 ± 1.8 mm vs. 18.4 ± 1.2 mm and vastus lateralis 22.3 ± 1.2 mm vs. 20.8 ± 1.3 mm); triacylglycerol (TAG) 0, 1, 2, 4; and 5 h after OFTT, TAG area under the curve (AUC) (5.79 ± 0.42 vs. 7.78 ± 0.68), and incremental AUC (?46.21 ± 14.42% vs. 7.78 ± 4.68%) were all significantly different post-training for HVRT versus LVRT, respectively (P < 0.05). The results of this investigation suggest that HVRT reduces PPL in postmenopausal women.  相似文献   
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89.
The patterns of scientific collaboration have been frequently investigated in terms of complex networks without reference to time evolution. In the present work, we derive collaborative networks (from the arXiv repository) parameterized along time. By defining the concept of affine group, we identify several interesting trends in scientific collaboration, including the fact that the average size of the affine groups grows exponentially, while the number of authors increases as a power law. We were therefore able to identify, through extrapolation, the possible date when a single affine group is expected to emerge. Characteristic collaboration patterns were identified for each researcher, and their analysis revealed that larger affine groups tend to be less stable.  相似文献   
90.
Curriculum, instruction, learning and assessment are the pulse of the school. They are what drive everything else. They are the currency through which we exchange thoughts and ideas. They are the passions that bind our organization together. Educators recognize the growing need for informed, skilled, thoughtful and compassionate citizens who value truth, openness, creativity, interdependence, balance and love as well as the search for personal and spiritual freedom in all areas of one's life. This demands that the school's curriculum must be open and flexible enough to accommodate these new perspectives. In this article, five themes will be presented as “lenses” with which to view a thought-filled curriculum.  相似文献   
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