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Metabolomics incorporates the study of metabolites that are produced and released through physiological processes at both the systemic and cellular levels. Biological compounds at the metabolite level are of paramount interest in the sport and exercise sciences, although research in this field has rarely been referred to with the global ‘omics terminology. Commonly studied metabolites in exercise science are notably within cellular pathways for adenosine triphosphate production such as glycolysis (e.g., pyruvate and lactate), β-oxidation of free fatty acids (e.g., palmitate) and ketone bodies (e.g., β-hydroxybutyrate). Non-targeted metabolomic technologies are able to simultaneously analyse the large numbers of metabolites present in human biological samples such as plasma, urine and saliva. These analytical technologies predominately employ nuclear magnetic resonance spectroscopy and chromatography coupled to mass spectrometry. Performing experiments based on non-targeted methods allows for systemic metabolite changes to be analysed and compared to a particular physiological state (e.g., pre-/post-exercise) and provides an opportunity to prospect for metabolite signatures that offer beneficial information for translation into an exercise science context, for both elite performance and public health monitoring. This narrative review provides an introduction to non-targeted metabolomic technologies and discusses current and potential applications in sport and exercise science. 相似文献
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Passow A. Harry Hilker Franz Lilge Frederic Suzuki Kenzo Wittig Horst E. Dobinson C. H. Chambre P. Tanner J. M. Williams John D. Takala Annika Anderson C. Arnold Engleman Finis E. Ahtik Vito Edlund Sven 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1964,10(4):485-505
International Review of Education - 相似文献
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Malva Villalón Emy Suzuki Maria Olivia Herrera Maria Elena Mathiesen 《International Journal of Early Years Education》2002,10(1):49-59
The aim of the study was to assess the quality of the different types of Chilean early childhood care and education programmes according to international standards. The sample included 120 centres representing the different types of pre-school programmes available, randomly selected from two different geographical regions of the country, where 52% of the population lives. This paper presents the structural and process characteristics observed in the classrooms, according to the results from the application of the Early Childhood Environment Rating Scale (ECERS). All the different types of pre-school programmes in Chile exhibited a minimum level of quality, even though there are differences among types of programmes and also according to the geographical area where they were settled. Results are compared with findings from the European Child Care and Education (ECCE) study developed in Austria, Germany, Portugal and Spain and from the Effective Provision of Pre-school Education (EPPE) project, developed in Britain. Cette étude se propose de évaluer la qualitédes différents programmes d'éducation et soin d'enfants au Chili, selon des standards internationaux. 120 centres ont été selectionnés au hasard, dans les deux départements du pays ou habite le 52% de la population. Cet article analyse les caractéristiques structurelles et du procès observes dans les classes, selon les résultats obtenus avec l'application de l'Early Childhood Environment Rating Scale (ECERS). Les différents types de programme on montré un niveau minimal de qualité même s'il y avait de différences significatives parmi les programmes et les départements. Les résultats sont compares avec l'étude European Child Care and Education (ECCE) développeé a le'Autriche, dans l'Allemagne, au Portugal et en Espagne et avec ceux projet Effective Provision of Pre-school Education (EPPE), développe a l'Angleterre. El propósito de este estudio fue la evaluación de la calidad de los diferentes programas de Educación y cuidado infantil existentes en Chile, aplicando criterios internacionales. La muestra incluyó 120 centros que representan los diferentes tipos de programas existentes en el país, seleccionados al azar, en las dos regiones, en las que habita el 52% de la población total. Este artículo analiza las características estructurales y del proceso observadas en las salas, de acuerdo a los resultados de la aplicación de la Early Childhood Environment Rating Scale (ECERS). Los distintos tipos de programas mostraron un nivel de calidad promedio correspondiente al rango minimo, aunque existen diferencias significativas entre ellos y también entre las dos regiones. Estos resultados fueron comparados con los hallazgos de los estudios-European Child Care and Education (ECCE), desarrollado en Austria, Alemania, Portugal y Espana y Effective Provision of Pre-school Education (EPPE), realizado en Inglaterra. 相似文献
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Hidekazu Kaneko Hiroto Sano Yasuhisa Hasegawa Hiroshi Tamura Shinya S. Suzuki 《Learning & behavior》2017,45(2):191-204
To investigate how motor sensation facilitates learning, we used a sensory–motor association task to determine whether the sensation induced by forced movements contributes to performance improvements in rats. The rats were trained to respond to a tactile stimulus (an air puff) by releasing a lever pressed by the stimulated (compatible condition) or nonstimulated (incompatible condition) forepaw. When error rates fell below 15%, the compatibility condition was changed (reversal learning). An error trial was followed by a lever activation trial in which a lever on the correct or the incorrect response side was automatically elevated at a preset time of 120, 220, 320, or 420 ms after tactile stimulation. This lever activation induced forepaw movement similar to that in a voluntary lever release response, and also induced body movement that occasionally caused elevation of the other forepaw. The effects of lever activation may have produced a sensation similar to that of voluntary lever release by the forepaw on the nonactivated lever. We found that the performance improvement rate was increased by the lever activation procedure on the incorrect response side (i.e., with the nonactivated lever on the correct response side). Furthermore, the performance improvement rate changed depending on the timing of lever activation: Facilitative effects were largest with lever activation on the incorrect response side at 320 ms after tactile stimulation, whereas hindering effects were largest for lever activation on the correct response side at 220 ms after tactile stimulation. These findings suggest that forced movements, which provide tactile and proprioceptive stimulation, affect sensory–motor associative learning in a time-dependent manner. 相似文献
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Ikuko Suzuki 《Compare》2002,32(2):243-259
Participation, a 'buzzword' in social development in both developed and developing countries, has several different interpretations in terms of purpose, form and implication. For instance, parents are encouraged to participate individually in choosing the school for their own children, and they are expected to participate collectively in school development through the work of school governing bodies. Furthermore, participation in education is often considered to be a means of assuring accountability of decentralised institutions. This paper explores the notion of parental participation in school governance, based on data obtained from field research in Uganda. It argues that parents' perceptions of the accountability of the school affect the way they participate in education. Thus, accountability is one of the crucial factors for realising local democracy through decentralisation. 相似文献
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Shinobu Suzuki 《Communication quarterly》2013,61(1):123-143
This study examines how an individual's argumentative communication traits and involvement, a situational factor, account for the way the individual structures his or her written argument. Research questions were posited to ask which of the 3 models—the Interaction Model, the Mediation Model, and the Simple Main Effects Model—best predicts the use of macro- and micro-structures of written argument. Logistic and multiple regression analyses were conducted to analyze 229 usable responses collected from Japanese college students. The results revealed that the Mediation Model and the Simple Main Effects Model are viable models. Argumentative traits and involvement interrelate to explain argument structures, revealing a somewhat complex but interpretable mechanism. 相似文献
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Mariko Suzuki 《International Journal of Science Education》2013,35(15):1773-1804
This research focused on the concept of “force” (“CHI‐KA‐RA” in Japanese) in Newtonian mechanics. The primary objective was to develop a tool, based on metaphor, to interpret student thinking in learning scientific topics. The study provides an example of using the tool to trace the process of mutual changes in thinking during a dialog among students who have different perspectives on the same topic. “Social metaphorical mapping” was used to interpret a dialog between two groups of junior high school students with different epistemological paradigms with regard to the concept of force (CHI‐KA‐RA) in the learning environment of a computer simulation. Both source domains were recontextualized through social metaphorical mapping and the process of mutual changes in concepts was traced. Participants noticed that the Buridanian 1 concept of“force” differs from the Newtonian concept of “force,” differentiated between the concepts of “force” that use the same Japanese term “CHI‐KA‐RA,” and noticed that the Buridanian concept of “force” resembles the Newtonian concept of “momentum.” 相似文献
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通过对《竹简孙子》和《魏武注孙子》一系的现行本《孙子兵法》加以比较,特别以《形篇》中"守"的解释为中心展开讨论,认为实现不战屈敌、保全本国为目的的国家战略,是符合孙武本意的。因此《孙子兵法》原本不存在"善攻者"三字,并非脱字、误字,这样文脉贯通,是《孙子兵法》本质意义上的字句。 相似文献