Screening for lead poisoning in urban school children of southern India using capillary and venous blood samples     

Herman S D'Souza  Geraldine Menezes  T Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):1-4

Our study aimed at comparing lead and zinc protoporphyrin (ZPP) levels in capillary and venous blood samples in a small population and to employ an easier method of sample collection for a major screening program in school children in major Indian cities. An awareness program on lead and its effects was conducted in two different schools. A total of thirty urban school children from South India, with an age group between 4–12 years consented for dual blood sampling and reported for the study. Venous and capillary blood samples were obtained simultaneously. Blood lead and zinc protoporphyrin (ZPP) levels were estimated using ESA Lead Analyzer and Haematofluorometer respectively. A significant correlation between capillary and venous ZPP (r=0.98) and lead (r=0.99) was observed. Rank sum test showed that there is no statistically significant difference between capillary and venous ZPP (P=0.891) and lead (P=0.672) values. This pilot study recommends that screening for lead may be done using capillary blood samples since significant correlation is observed between capillary and venous blood measurements. Obtaining samples using this mode is a non-invasive, less expensive, quick and easy method in children. Appropriately performed capillary sampling may be considered as an acceptable alternative to venipuncture for screening of blood for lead poisoning both in children and adults.  相似文献   

Collaborative working in a large pharmaceutical company: Developing better practices through a structurational schema     

James  Laurence 《International Journal of Information Management》2005,25(6):551-564

This paper presents the ongoing case study of a large pharmaceutical organisation currently undertaking a number of changes to their work practices. These collaborative changes are being facilitated by groupware systems. In many instances this has led to the rejection of or resistance to the more complex tools. The paper outlines research, based on a perspective informed by structuration theory, that provides the organisation with an approach to supporting staff in this new ‘collaborative environment’. An example, drawn from the case study, shows how such support might be developed and presents a set of recommendations for supporting a particular group, based on this research schema.  相似文献   

Study of magnesium,glycosylated hemoglobin and lipid profile in diabetic retinopathy     

Ishrat Kareem  S. A. Jaweed  J. S. Bardapurkar  V. P. Patil 《Indian journal of clinical biochemistry : IJCB》2004,19(2):124-127

The present study was undertaken in 100 subjects, 30 diabetics without complication (group I), 40 diabetics with retinopathy (group II) and 30 non diabetic as normal control group (group III). Blood sugar levels, magnesium, cholesterol and triglyceride were analyzed from plasma and serum. The results were correlated with degree of diabetic control from the levels of glycosylated hemoglobin. Serum magnesium levels in group II were found to be significantly lowered than in group I. There was also significant difference in magnesium levels of group I and group III. We found a significant correlation between the glycosylated hemoglobin and magnesium levels in our study. The results also indicate that the patients with diabetic retinopathy showed significant rise in serum cholesterol and triglyceride. Probably hypomagnesemia and increased serum cholesterol and triglyceride levels are responsible for microvascular changes in diabetes leading to retinopathy. The purpose of this study was thus to gather information about the degree of control of diabetes and magnesium status.  相似文献   

Feedback factorizing control of ₃-D transfer functions via a canonical state-space model     

S.G. Tzafestas  N.J. Theodorou 《Journal of The Franklin Institute》1983,316(6):419-433

The problem factorizing (separating) the transfer function of a given SISO 3-D discrete system, ie of a system depending on three independent variables, is considered. The 3-D system is assumed to be available in its transfer function representation, which is converted to a canonical state-space model by a simple inspection procedure. Then applying state-feedback to this canonical model we choose the feedback matrix gain (under certain conditions) such that the transfer function of the closed-loop system has the desireed factorized form, ie a product of three 1-D transfer functions each one being dependent on a single variable. The method is illustrated by a nontrivial numerical example.  相似文献   

Seawater desalination by reverse osmosis     

Hermann W. Pohland M.S.  Ph.Doc. 《Endeavour》1980,4(4):141-147

Until comparatively recently the purification of sea or brackish water depended largely on some form of distillation. In recent years, however, a number of industrial concerns have directed increasing attention to processes depending on reverse osmosis. A number of large plants have been installed and this article reviews the present state of reverse osmosis technology and the factors determining its efficiency. Its advantages include its relatively low fuel consumption, and in this respect further substantial savings are in prospect.  相似文献   

Effect of labour and surgical stress on serum free fatty acids     

T. M. Chary  A. S. Sane 《Indian journal of clinical biochemistry : IJCB》1996,11(1):73-76

Serum free fatty acids (FFA) in 100 parturient (50 primiparous and 50 multiparous volunteers) and 50 female patient (30 patients 20–30 years age group and 20 patients 31–50 yrs age group) volunteers undergoing elective major abdominal surgery were monitored during different stages of delivery and surgery respectively. FFA increased in both primiparous and multiparous from full term (46 mg%) to second stage of labour (60 mg%) and gradually decreased to 38 mg% on the third day postpartum. The intergroup comparison between primiparous and multiparous was significant. Surgical stress also increased FFA from the day of admission (21 mg%) to the preoperative stage (35 mg%). The intergroup comparison between 20–30 yrs age group and 31–50 yrs age group did not show any significant change.  相似文献   

Standardization of a dilution method for cyclosporin (C2) estimation in renal transplant patients     

G. Kusumanjali  Chinnapu G. Reddy  A. S. Kanagasabapathy  Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2005,20(2):146-149

Accurate monitoring of blood cyclosporin C2 levels is vital to prevent over immunosuppression and acute renal toxicity in patients who receive organ transplant. The matrix used to dilute patients’ C2 samples prior to the assay affected the final measured values. Hence there was a need to develop a method of dilution that would accurately estimate C2 levels when cyclosporin levels were beyond the calibration range of the method employed. Whole blood, cyclosporin free hemolysate and cell and protein free supernatant obtained after pretreatment of normal blood were used to dilute patients’ C2 samples. C2 was measured in 188 patients using the supernatant method of dilution. C2 was correlated with Co and dose of cyclosporin received by the patient. The use of cell and protein free supernatant obtained after pretreatment of normal blood as a C2 diluent detected higher levels of C2 in the sample. Measured C2 correlated significantly with Co and the cyclosporin dose received by the patient. The uniformly aqueous cell and protein free supernatant ensures uniform dilution of the patients’ C2 sample and measures higher cyclosporin levels.  相似文献   

Pre and post analytical errors in lipid determination     

S. Narayanan 《Indian journal of clinical biochemistry : IJCB》1996,11(1):12-16

A number of pre analytical variables affect lipid determinations. These include posture during blood sampling, the duration of tourniquet application and fasting, the time of day when blood is collected, the concentration and type of anticoagulant used for blood collection to name just a few. Effect of life style such as diet, alcohol and caffeine consumption, smoking, and exercise influence lipid determinations. Disease states such as infection, diabetes, nephrotic syndrome and heart disease culminating in myocardial infarction and conditions such as obesity and pregnancy influence lipid profiles. A variety of drugs ranging from diuretics to oral contraceptives to immunosuppressive drugs induce alterations in the patient's lipid profile. Post analytical variables impacting on the interpretation of laboratory data such as in the determination of the true mean of a lipid constituent would depend on the number of specimens analyzed, the analytical variability of the method and approaches to handling data such as the use of relative range to estimate the effect of biological variability on the computed mean value.  相似文献   

Study of adenosine deaminase activity in various arthritic conditions     

R. Kumar  S. B. Pachori  G. K. Senger  Satyanand  L. D. Joshi 《Indian journal of clinical biochemistry : IJCB》1994,9(2):72-74

Aim of present study was to compare the adenosine deaminase (ADA) activity in various types of arthritis conditions with synovial effusion. No. significant difference was observed in ADA activity in serum of control and study groups but results have shown a definite pattern of ADA activity in synovial fluid in various arthritic conditions. The highest value of ADA activity was observed in synovial fluid of patients with tubercular arthritis followed by rheumatoid, septic, osteo and post traumatic arthritis. Thus measurement of ADA activity in synovial fluid can be used as a parameter of differential diagnosis of arthritis specially tubercular in initial stages.  相似文献   

Query processing in a retrospective document retrieval system that uses word fragments as language elements     

E.J. Schuegraf  H.S. Heaps 《Information processing & management》1976,12(4):283-292

The structure of a retrospective information retrieval system that uses equifrequent word or text fragments is described, and its advantages over word oriented systems are mentioned briefly. Word fragments are proposed as retrieval elements, and a discussion is given of the changes required in order to process a query. Some necessary modifications in the treatment of logical operators are described, and two conditions are postulated as necessary for the successful operation of the system. Aspects of query processing are illustrated by experimental results obtained from single and two-term queries applied to a portion of the MARC tapes.  相似文献