Lipid peroxidation and the levels of antioxidant enzymes in coronary artery disease     

K. Kaur  G. Bedi  M. Kaur  Anil Vij  Inderpreet Kaur 《Indian journal of clinical biochemistry : IJCB》2008,23(1):33-37

Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Traditional risk factors account for only half of the morbidity and mortality from coronary artery disease. There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process. The present study was undertaken to evaluate the level of lipid peroxidation (by measuring malondialdehyde) and antioxidant enzymes (ceruloplasmin, glutathione, superoxide dismutase) in coronary artery disease. Serum malondialdehyde levels and serum ceruloplasmin levels were significantly raised in all the subgroups of study group as compared to control group (p<0.001). Whole blood glutathione levels and hemolysate superoxide dismutase activity was significantly decreased in all the subgroups of study group as compared to control group (p<0.001). Above results suggests that the patients of coronary artery disease show increased oxidative stress and decreased levels of antioxidant enzymes. So it is recommended that the management protocol for coronary artery disease patients should include antioxidant supplementation along with simultaneous lowering of lipid peroxidation.  相似文献   

Sex hormone binding globulin in breast cancer     

Dayalu Naik S L  Suresh Hedau  Anil Kumar Bahadur  Renuka Saha  Sudershan Kaur  Amitabha Ray 《Indian journal of clinical biochemistry : IJCB》2008,23(3):250-254

The present study was undertaken to determine the significance of sex hormone binding globulin, the major and specific binding protein for testosterone and estradiol, in breast cancer. Among breast cancer patients, lower serum levels of Sex hormone binding globulin and higher levels of testosterone were observed. Sex hormone binding globulin showed an inverse relationship with testosterone and total cholesterol, and a direct relation with HDL-cholesterol. By the western blot analyses, Sex hormone binding globulin was detected in all biological samples that we examined. In the breast tumor tissue sections, immuno-staining for Sex hormone binding globulin was confined in cell cytoplasm and 29% cases were positive, which showed no association with the investigated prognostic markers of breast cancer such as ER and HER-2/neu over-expression. In this study, decreased circulating levels of Sex hormone binding globulin in breast cancer patients possibly indicate higher bioavailable estrogens.  相似文献   

Effect of felodipine on the serum lipid profile of patients with hypertension     

Maninder Kaur  Kiranjeet Kaur  Gurdeep Kaur Bedi  Gurpreet Singh Sidhu  Roopan Sikand 《Indian journal of clinical biochemistry : IJCB》2000,15(2):63-67

Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol, serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive patients in a positive way.  相似文献   

Antioxidant Potential,Antinutrients, Mineral Composition and FTIR Spectra of Legumes Fermented with Rhizopus oligosporus     

Barinderjeet Singh Toor  Amarjeet Kaur  Param Pal Sahota  Jaspreet Kaur 《Food Technology and Biotechnology》2021,59(4):530

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Application of Tucatinib and Trastuzumab: Dual Anti HER2 Therapy Against HER2 Positive Breast Cancer     

Sumanpreet Kaur  Rajasri Bhattacharyya  Dibyajyoti Banerjee  Jaya Shukla 《Indian journal of clinical biochemistry : IJCB》2021,36(1):124

Synergism in action of tucatinib and trastumab is reported in breast cancer management. However, its molecular basis is yet to be determined. In this context we attempted to provide an explanation at the molecular level by performing in silico experimentation and coupling its result with already available published observations. Our study will provide basis for planning further experimental study for unravelling the truth.  相似文献   

“Silent Hypoxemia” Leads to Vicious Cycle of Infection,Coagulopathy and Cytokine Storm in COVID-19: Can Prophylactic Oxygen Therapy Prevent It?     

Anshika Chauhan  Rajandeep Kaur  Prantar Chakrbarti  Arnab Pal 《Indian journal of clinical biochemistry : IJCB》2021,36(4):468

Humankind is facing its worst pandemic of the twenty-first century, due to infection of a novel coronavirus named as SARS-CoV2, started from Wuhan in China. Till now, 15 million people are infected, causing more than 600,000 deaths. The disease, commonly known as, COVID-19, was initially thought to be associated with ARDS only, but later on revealed to have many unexplained and atypical clinical features like coagulopathy and cytokinemia, leading to multi-organ involvements. The patients also suffer from ‘Silent Hypoxemia’, where there is no immediate respiratory signs and symptoms even though alarmingly low SpO₂ level. We hypothesize that this covert hypoxemia may lead to molecular changes exacerbating coagulopathy and cytokine storm in COVID19 patients, which again, in turn, causes a vicious cycle of more hypoxemia/hypoxia and progression of the infection to more severe stages through HIF-1α dependent pathway. Although molecular mechanisms are yet to be substantiated by scientific evidence, hypoxemia remains an independent worsening factor in serious COVID 19 patients. Keeping all in mind, we propose that even in the early and asymptomatic cases, prophylactic oxygen therapy to be initiated to break the vicious cycle and to reduce the mortality in COVID 19 to save precious human lives.  相似文献   

“How are running shoes assessed? A systematic review of characteristics and measurement tools used to describe running footwear”     

Codi A. Ramsey  Peter Lamb  Mandeep Kaur  G. David Baxter  Daniel Cury Ribeiro 《Journal of sports sciences》2019,37(14):1617-1629

Background: Many footwear characteristics are argued as risk factors for running related injuries (RRI). Several footwear assessment tools are available; however, their use in studies of RRI is unknown. Objective: This systematic review evaluated the characteristics and methods of assessing footwear in studies of RRI. Design: Five online databases were searched for studies on adult runners, in running style footwear, who experienced running-related pain or injury. The methodological quality of included articles was independently assessed by two raters using a modified Downs and Black checklist. Study and participant characteristics, footwear assessment tools used, and footwear characteristics reported were extracted for qualitative synthesis. Results: Twenty-four articles were included in the review. Low risk of bias was determined for 11 (44%) of the included studies. Twenty-eight different footwear characteristics were grouped into four categories: nomenclature, measurements, qualitative features, and subjective features. Fifteen different methods for assessing the 28 footwear characteristics were reported among the included studies. Only three methods were described previously, as valid and reliable. Conclusion: Differences in assessing footwear may mask the link between footwear characteristics and injury risk. Systematic footwear assessments and nomenclature are needed to evaluate the effects of footwear characteristics on RRI.  相似文献   

The trials and tribulations of partnerships in refugee settlement services in Australia     

Ravinder Kaur Sidhu  Sandra Taylor 《教育政策杂志》2013,28(6):655-672

The ascendency of neoliberal ideas in education and social policy in the 1980s and 1990s was succeeded in the new millennium by a ‘new’ social democratic commitment with emphases on community empowerment, building social capital and a ‘whole of government’ approach to partnering with civil society to meet community needs. In Australia, this approach has resulted in the development of partnerships between schools and community organisations formed as part of a targeted, holistic approach to service delivery to meet the settlement and educational needs of refugee youth. Drawing on interviews conducted with community workers and government officers involved in the school–community partnerships, we document how these partnerships are working ‘on the ground’ in Queensland schools. We analyse our findings against the international literature on changing notions of neoliberal governance, and discuss the implications of the shift to the ‘partnering state’ for schools and community organisations working with refugee young people.  相似文献   

Ambiguous author query detection using crowdsourced digital library annotations     

Xiaoling Sun  Jasleen Kaur  Lino Possamai  Filippo Menczer 《Information processing & management》2013

The name ambiguity problem is especially challenging in the field of bibliographic digital libraries. The problem is amplified when names are collected from heterogeneous sources. This is the case in the Scholarometer system, which performs bibliometric analysis by cross-correlating author names in user queries with those retrieved from digital libraries. The uncontrolled nature of user-generated annotations is very valuable, but creates the need to detect ambiguous names. Our goal is to detect ambiguous names at query time by mining digital library annotation data, thereby decreasing noise in the bibliometric analysis. We explore three kinds of heuristic features based on citations, metadata, and crowdsourced topics in a supervised learning framework. The proposed approach achieves almost 80% accuracy. Finally, we compare the performance of ambiguous author detection in Scholarometer using Google Scholar against a baseline based on Microsoft Academic Search.  相似文献   

Sport,Animals, and Society     

Harpreet Kaur Vohra 《Sport in History》2016,36(2):273-275

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