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A new, simple classroom technique helps cell biology students understand principles of Michaelis-Menten enzyme kinetics. A student mimics the enzyme and the student's hand represents the enzyme's active site. The catalytic event is the transfer of marbles (substrate molecules) by hand from one plastic container to another. As predicted, increases in marble concentration increase the number of marbles transferred per unit time (initial rate, V(0)) until the turnover number becomes rate limiting and V(0) approaches the maximum velocity (V(max)), as described by the Michaelis-Menten equation. With this demonstration, students visualize an important concept: the turnover number is constant and independent of marble concentration. A student assessment of this exercise showed that it helped students visualize the turnover number and V(max) but not K(m), the marble concentration at which V(0) is one-half V(max). To address the concept of K(m), we use supplemental laboratory and lecture exercises. This exercise with plastic containers and marbles is equally suited to demonstrate the kinetics of carrier-mediated membrane transport. We conclude that this exercise helps students visualize the turnover number and V(max) and gives students important insights into the kinetic parameters used to characterize the catalytic activity of enzymes and membrane transporters.  相似文献   
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全面预算管理是以企业战略规划为依据,以量化的、综合的、涵盖企业经营全过程的全面预算为基础,以全员、全过程、全方位控制为特征的企业内部管理控制系统。从我国会展行业的实际现状出发,从理论和实践两方面对全面预算管理的应用进行探讨,运用全面预算管理的基本理论,深入分析会展行业特点及在实施过程中存在的问题,并有针对性地提出改进措施,以此抓住会展企业预算管理工作的关键环节,探索建立起一套适合其自身发展的预算管理体系。  相似文献   
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The induction of beginning teachers continues to occupy a significant position on educational policy agendas as a crucial dimension in the formation of a teacher and one upon which an emergent career is built. Whilst there is growing impetus to establish an induction model that constitutes a relevant, fulfilling experience, current arrangements continue to vary throughout the UK. This paper describes induction as it affected a sample of beginning teachers in Northern Ireland, where there is a dearth of permanent positions for those newly qualified. Highly contrasting experiences of the induction year emerged between graduates in permanent and one‐year temporary positions, and those who were short‐term temporary and supply teachers. The former completed a meaningful induction whereas the latter, because of sporadic, fragmented employment, did not. A flexible model of induction is proposed, with collaborative involvement of the higher education institutions, the schools and the local education authorities.  相似文献   
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ABSTRACT

The UCF Libraries are continually developing new forms of library instruction to meet the needs of a growing student body with the same number of librarians. These efforts attempt to find the balance between impersonal online tutorials and time-intensive embedded librarianship. The pros and cons of each model employed at our growing university are discussed, along with strategies to identify and implement sustainable library instruction in an academic library.  相似文献   
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