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21.
Healthcare workers are at risk of sharps injuries and subsequent infection from more than 40 bloodborne pathogens or species. Hepatitis B Virus (HBV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) together account for the vast majority of cases. The Directive 2010/32/EU “Prevention from sharp injuries in the hospital and healthcare sector”, issued to protect workers from these risks, requires an integrated approach to prevention including awareness-raising, education, training, elimination of unnecessary needles, safe procedures for sharps use and disposal, banning of recapping, vaccination, use of personal protective equipment, provision of safety-engineered devices, and appropriate surveillance, monitoring, response and follow-up.As laboratories represent a high-risk setting both in the preanalytical and analytical phase, we reviewed accidents and prevention in this setting in the light of the new legislation.Phlebotomy is the procedure carrying the highest risk of exposure and infection, involved in 30–50% of HIV and HCV cases detected in nationwide systems following accidental blood exposures implemented since the 1990s in Italy and France. In laboratories, problems in the management of sharps containers, recapping, needle disassembly by hand and blood transfer from syringes into tubes were observed and accounted for two-thirds of injuries. These accidents could be reduced through education and monitoring of behaviours, and introduction of medical devices incorporating safety-engineered protection mechanisms with appropriate training. Laboratory staff should be immunized against HBV, and know policies and procedures for the post-exposure management and prophylaxis. The management commitment to safety is crucial to ensure the necessary support to these changes.  相似文献   
22.
The survey of materials constituting the buildings of the ancient city centre of Naples and of their decay typologies was carried out. Reports were entered in a database which enabled us to draw two thematic maps in a digital format: one of materials and lithotypes, and one showing weathering. On this basis, quantitative evaluations of the lithotypes were carried out. The research pointed out that the use of different lithotypes was mainly as a result of their availability and/or ease of exploitation. Furthermore, the importance of the preservation of the quarrying sites was stressed, both for their historical and cultural interest and, above all, for possible forthcoming provisioning finalized to restorations. The analysis of the results, made on a geo-mineralogical basis, as well as the thematic maps, gives a basic tool which will be very useful to those professionals involved in preservation of cultural heritage.  相似文献   
23.
A recent assessment (Giovannelli, G., D'Urzo, L., Maggiulli, G., Natali, S., Pagliara, C., Sgura, I. & Bozzini, B. 2010. Journal of Solid State Electrochemistry, 14: 479–94.) of the corrosion state of a late Bronze Age artefact (ca. 1100 BCE) exposed to a coastal environment, based on optical and scanning electron microscopies, X-ray fluorescence mapping, and X-ray diffractometry, led to recognition of bronze disease conditions essentially related to the presence of nantokite locked inside mesoscopic subsurface pits. The object was then treated successfully with a novel electrochemical approach specifically designed to allow penetration of the electric field into deep, screened pits. In order to further develop and optimize this promising approach by fine-tuning the capabilities of electrochemical control, more insight is required on the specific morphochemistry of the corrosion product scenario. To this end, here we report a space-dependent compositional and chemical-state analysis, performed with synchrotron-based scanning photoelectron microspectroscopy. The investigated object consists of a segregated cast bronze. The prevailing corrosion form is preferential attack of Sn-rich phases, accompanied by a synergistic type of Sn and Cu attack triggered by the peculiar type of decuprification taking place in a bronze disease framework and characterized by the formation of Sn(OH)Cl as a result of local HCl generation in the Cu corrosion process.  相似文献   
24.
Citrulline-malate (CM) is a precursor to nitric-oxide (NO) in the NO synthase (NOS) pathway and is suggested to increase exercise performance in younger individuals. With age, NO production decreases and augmented NO production may provide beneficial effects on sports performance among masters athletes (MAs). Purpose: To examine the effects of acute CM supplementation on grip strength, vertical power, and anaerobic cycling performance in female, MA tennis players. Methods: Seventeen female MA (51?±?9 years) completed two double-blind, randomized trials consuming CM (12?g dextrose?+?8?g CM) and placebo (PLA) (12?g dextrose). One hour after consumption, subjects completed grip strength, vertical power, and Wingate anaerobic cycling assessments in respective order. Maximal and average grip strength, peak and average vertical power, anaerobic capacity, peak power, explosive power, and ability to sustain anaerobic power were calculated from the tests. Results: When consuming CM, participants exhibited greater maximal (p?=?.042) and average (p?=?.045) grip strength compared to PLA. No differences existed between trials for peak (p?=?.51) or average (p?=?.51) vertical power. For the Wingate, peak power (p?p?p?Conclusions: These data suggest that consuming CM before competition has the potential to improve tennis match-play performance in masters tennis athletes. However, this study utilized a controlled laboratory environment and research evaluating direct application to on-court performance is warranted.  相似文献   
25.
In recent years, knowledge structuring is assuming important roles in several real world applications such as decision support, cooperative problem solving, e-commerce, Semantic Web and, even in planning systems. Ontologies play an important role in supporting automated processes to access information and are at the core of new strategies for the development of knowledge-based systems. Yet, developing an ontology is a time-consuming task which often needs an accurate domain expertise to tackle structural and logical difficulties in the definition of concepts as well as conceivable relationships. This work presents an ontology-based retrieval approach, that supports data organization and visualization and provides a friendly navigation model. It exploits the fuzzy extension of the Formal Concept Analysis theory to elicit conceptualizations from datasets and generate a hierarchy-based representation of extracted knowledge. An intuitive graphical interface provides a multi-facets view of the built ontology. Through a transparent query-based retrieval, final users navigate across concepts, relations and population.  相似文献   
26.
IntroductionThe measurement of serum free light chain (FLC) represents a fundamental aspect on the assessment of patients with monoclonal gammopathies (MG). Different analytical methods for FLC have become available with the possibility to obtain different value with a substantial impact on the assessment of patients with MG. This study aimed to evaluate FLC results obtained with two different assays and how the difference value obtained can impact in the patient’s assessment.Materials and methodsNinety-three patient serum samples that underwent analysis for FLC with two different methods, Serum Freelite (The Binding Site, Birmingham, UK) and N-Latex FLC (Siemens, Marburg, Germany), were included in this retrospective study. Statistical analysis was performed to evaluate correlation, difference, and the grade of concordance between the results obtained with the two methods.ResultsSignificant statistical differences between the results obtained from the two methods were found (P < 0.05). A good correlation was found (0.99 for κ FLC, 0.95 for λ FLC, and 0.94 for the κ/λ ratio, respectively). We found a weighted kappa value of 0.65 for κ/λ ratio, 0.65 for λ FLC and 0.90 for κ FLC. A positive bias found with the Bland-Altman plot mirrors overestimation of κ FLC and κ/λ ratio with Freelite compared to N-Latex, whilst a negative bias underscores underestimation of λ FLC by Freelite compared to N-Latex.ConclusionAlthough in general the concordance between Freelite and N-Latex appears satisfactory, several discrepancies could be evidenced and consequently the two assays are not interchangeable.  相似文献   
27.
Despite the growing interest, Open Innovation (OI) in Intangible Assets (IAs) research is still fragmented and displays a limited contextual focus. This paper aims to provide a clearer view of these issues and represents a first step toward filling such research gap. A systematic literature review and a synthesis of high-quality contributions with a focus on a general overview of research on OI and IAs in OI processes have been carried out. By critically evaluating the current body of literature and definitions, we have moved a step further toward comprehending the multiple facets of existing research and highlight several promising areas for future development. In particular, we have analyzed the role of IAs in OI practices by selecting a synthesis and a critical review of their different exploitations. We have combined multiple algorithms to produce a clear topical taxonomy of the multiple strands of research lying at the interface of OI and IAs.  相似文献   
28.
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