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11.
Supriya Simon A Dinesh Roy D Jayapal V Vijayakumar T 《Indian journal of clinical biochemistry : IJCB》2011,26(1):50-56
Cardiovascular autonomic neuropathy (CAN) is one of the most clinically significant complications of diabetes mellitus. Even
though many ethological factors have been attributed for the pathogenesis of this disease no attempts were made to correlate
DNA damage as a causative factor. Hence the present study was undertaken to asses the extent of somatic DNA damages by cytokinesis-block
micronuclei assay (CBMN). An attempt is also being made to correlate the habits and/or risk factors and socioeconomic status
with CAN. The CBMN frequency of 46 patients suffering from autonomic neuropathy was compared with that of 25 healthy age and
sex matched controls. All the subjects were suffering from type 2 diabetes for at least 8 years and have varying degrees of
coronary artery diseases. The mean CBMN frequency of the patients was statistically higher than that of the healthy control
subjects (P < 0.05). The CBMN frequency was found to be significantly altered in CAN patients who where physical inactivity and smoking.
A significant correlation could also be observed between CAN and smoking, diabetes mellitus, hypertension, dyslipidemia, abdominal
obesity, and physical activity. 相似文献
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Ten milligram of pure gold foil was given by mouth for 16 days. Routine blood chemistry was done before and after gold therapy and repeated after 3 weeks of cessation of therapy. All the blood values were well within normal range and variations, except the enzymes—creatine phosphokinase and lactate dehydrogenase, which decreased substantially on gold foil ingestion indicating possible inhibition of these blood enzymatic activity by gold. 相似文献
13.
K Reshma V Rao Ashalatha M Dinesh DM Vasudevan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):160-164
Flavonoids extracted from the leaves of Indian holy basil, Ocimum sanctum showed promising results as radioprotector in rodents.
Hence it was thought pertinent to analyze the antioxidants of erythrocytes in oral cancer patients who were concurrently treated
with radiation and ocimum flavonoids. Oral cancer patients consisted of 2 groups. Group A (n=17) received radiation alone
while Group B(n=17) received radiation and ocimum flavonoids(OF). Samples of heparinised blood were collected prior to treatment,
15 and 30 days respectively after treatment. Blood from normal healthy volunteers were taken as controls (n=25). Erythrocytes
were analyzed for the antioxidants viz. glutathione, glucose 6 phosphate dehydrogenase, glutathione peroxidase and superoxide
dismutase by the standard methods. Results of analysis indicated that erythrocytes from cancer patients (Group A and B) had
significantly high glutathione levels before as well as after treatment compared to controls. It was observed that Group B
which received OF showed a significant reduction in glutathione levels in comparison with Group A. All the other parameters
showed no statistical significant changes. Results of the study suggest that erythrocytes from cancer patients responded to
oxidative stress by elevating glutathione levels, while a decrease in glutathione levels observed in Group B, could be due
to the free radical scavenging effect of OF, sparing the glutathione. However OF did not seem to exert its effect on other
antioxidants of erythrocytes. 相似文献
14.
Dil-Afroze Dinesh Sharma G. N. Dhobi Sonaullah Shah Rafiqa Eachkoti Ishraq Hussain Zafar A. Shah Mushtaq A. Siddiqi 《Indian journal of clinical biochemistry : IJCB》2006,21(2):76-79
Pleural effusion is one of the commonest presentations of tuberculosis, the clinical manifestations being typically abrupt
resembling bacterial pneumonia. Since delayed hypersensitivity is the underlying immune response, bacterial load is very low.
Owing to these facts, tuberculous pleurisy as an extra-pulmonary disease poses a diagnostic dilemma. The conventional bacteriological
methods rarely detect Mycobacterium tuberculosis in pleural fluid and are of limited use in diagnosis of tuberculous pleurisy.
We evaluated the efficacy of polymerase chain reaction (PCR) in the diagnosis of tuberculous pleurisy by targeting the gene
segment coding for MPB64 protein specific forMycobacterium tuberculosis. Based on the clinical criteria, 82 patients with lymphocytic exudative pleural effusion were included in the study. Patients
were analyzed in two groups; one group consisting of 48 patients of tubercular pleural effusion confimed by various diagnostic
procedures and another group of 34 patients comprising of non-tubercular pleural effusion. There were no false positive results
by PCR and the specificity worked out to be 100%. Twenty two patients tested positive for Mantoux with a sensitivity of 45%.
ZN-staining for AFB was found in samples from 15 patients (20% sensitivity). ADA was positive for 28 patients with a sensitivity
of 53%. PCR was positive for 32/48 patients (67% sensitivity). Thus, PCR was found to be more sensitive than any other conventional
method in diagnosis of clinically suspected tubercular pleurisy. 相似文献
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The eigenface method that uses principal component analysis （PCA） has been the standard and popular method used in face recognition. This paper presents a PCA - memetic algorithm （PCA-MA） approach for feature selection. PCA has been extended by MAs where the former was used for feature extraction/dimensionality reduction and the latter exploited for feature selection. Simulations were performed over ORL and YaleB face databases using Euclidean norm as the classifier. It was found that as far as the recognition rate is concerned, PCA-MA completely outperforms the eigenface method. We compared the performance of PCA extended with genetic algorithm （PCA-GA） with our proposed PCA-MA method. The results also clearly established the supremacy of the PCA-MA method over the PCA-GA method. We further extended linear discriminant analysis （LDA） and kernel principal component analysis （KPCA） approaches with the MA and observed significant improvement in recognition rate with fewer features. This paper also compares the performance of PCA-MA, LDA-MA and KPCA-MA approaches. 相似文献
18.
Himani Rathi Vishakha Burman Sudip Kumar Datta Satya Vati Rana Anissa Atif Mirza Sarama Saha Raman Kumar Manisha Naithani 《Indian journal of clinical biochemistry : IJCB》2021,36(1):3
In December 2019, Wuhan city in the Hubei province of China reported for the first time a cluster of patients infected with a novel coronavirus, since then there has been an outburst of this disease across the globe affecting millions of human inhabitants. Severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2), is a member of beta coronavirus family which upon exposure caused a highly infectious disease called novel coronavirus disease-2019 (COVID-19). COVID-19, a probably bat originated disease was declared by World Health Organization (WHO) as a global pandemic in March 2020. Since then, despite rigorous global containment and quarantine efforts, the disease has affected nearly 56,261,952 laboratory confirmed human population and caused deaths of over 1,349,506 lives worldwide. Virus passes in majority through respiratory droplets and then enters lung epithelial cells by binding to angiotensin converting enzyme 2 (ACE2) receptor and there it undergoes replication and targeting host cells causing severe pathogenesis. Majority of human population exposed to SARS-CoV-2 having fully functional immune system undergo asymptomatic infection while 5–10% are symptomatic and only 1–2% are critically affected and requires ventilation support. Older people or people with co-morbidities are severely affected by COVID-19. These categories of patients also display cytokine storm due to dysfunctional immune response which brutally destroys the affected organs and may lead to death in some. Real time PCR is still considered as standard method of diagnosis along with other serology, radiological and biochemical investigations. Till date, no specific validated medication is available for the treatment of COVID-19 patients. Thus, this review provides detailed knowledge about the different landscapes of disease incidence, etiopathogenesis, involvement of various organs, diagnostic criteria’s and treatment guidelines followed for management of COVID-19 infection since its inception. In conclusion, extensive research to recognize novel pathways and their cross talk to combat this virus in precarious settings is our future positive hope. 相似文献
19.
The reconfigurable manufacturing system （RMS） is the next step in manufacturing, allowing the production of any quantity of highly customized and complex parts together with the benefits of mass production. In RMSs, parts are grouped into families, each of which requires a specific system configuration. Initially system is configured to produce the first family of parts. Once it is finished, the system will be reconfigured in order to produce the second family, and so forth. The effectiveness of a RMS depends on the formation of the optimum set of part families addressing various recon figurability issues. The aim of this work is to establish a methodology for grouping parts into families for effective working of RMS. The methodology carried out in two phases. In the first phase, the correlation matrix is used as similarity coefficient matrix. In the second phase, agglomerative hier archical Kmeans algorithm is used for the parts family for mation resulting in an optimum set of part families for reconfigurable manufacturing system. 相似文献
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