Recent feyerabendiana     

George Couvalis 《Metascience》2001,10(1):39-49

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Circulating Thrombotic Risk Factors in Young Patients with Coronary Artery Disease Who Are on Statins and Anti-platelet Drugs     

Reema George  Harikrishnan Sivadasanpillai  Narayani Jayakumari  Anugya Bhatt  Jissa V. Thulaseedharan  Jaganmohan A. Tharakan 《Indian journal of clinical biochemistry : IJCB》2016,31(3):302-309

Thrombotic risk factors may contribute to premature coronary artery disease (CAD), in addition to the conventional risk factors. There is paucity of data on studies evaluating the role of thrombotic factors in premature CAD in Indian patients. Thus a case–control study was performed to evaluate the role of thrombotic and atherogenic factors in young patients with angiographically proven CAD who are on treatment with statins and anti-platelet drugs. 152 patients (≤55 years) with angiographically proven CAD and 102 asymptomatic controls were recruited. Clinical and biochemical data were obtained in both groups. Blood levels of thrombotic factors-fibrinogen, antithrombin-III, tissue-plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von-Willebrand factor (v-WF), lipoprotein(a) [Lp(a)] and homocysteine were analyzed. Patients had high levels of conventional CAD risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia and positive family history) compared to controls. Logistic regression analysis revealed that low antithrombin-III (odds ratio/OR 11.2; 95 % confidence interval/CI 2.29–54.01), high fibrinogen (OR 6.04; 95 % CI 1.09–33.21) and high Lp(a) (OR 4.54; 95 % CI 0.92–22.56), as important, independent risk factors in patients. PAI-1(OR 0.15; 95 % CI 0.03–0.69) levels were significantly lower in patients. But other thrombotic risk factors studied (t-PA, v-WF and homocysteine) were comparable among patients and controls. The treatment using statins and anti-platelet drugs might be contributing to the control of some of the thrombotic risk factors. The strategies aiming at lowering the levels of thrombotic risk factors along with conventional risk factors may be useful in primary and secondary prevention of CAD.  相似文献   

Using the Content of Online Privacy Notices to Inform Public Policy: A Longitudinal Analysis of the 1998-2001 U.S. Web Surveys     

George R. Milne  Mary J. Culnan 《The Information Society》2002,18(5):345-359

In the United States, Congress has had a long-standing interest in consumer privacy and the extent to which company practices are based on fair information practices. Previously, public policy was largely informed by anecdotal evidence about the effectiveness of industry self-regulatory programs. However, the Internet has made it possible to unobtrusively sample web sites and their privacy disclosures in a way that is not feasible in the offline world. Beginning in 1998, the Federal Trade Commission relied upon a series of three surveys of web sites to assess whether organizations post online privacy disclosures and whether these disclosures represent the U.S. definition of fair information practices. While each year's survey has provided an important snapshot of U.S. web-site practices, there has been no longitudinal analysis of the multiyear trends. This study compares a subset of equivalent individual-level web-site data for the 1998, 1999, 2000, and 2001 web surveys. Implications for using this type of research to inform public policy are discussed.  相似文献   

The Official Ideology of American Law Schools     

George W. DentJr 《Academic Questions》2011,24(2):185-193

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Effect of foster care on young children's language learning     

Windsor J  Benigno JP  Wing CA  Carroll PJ  Koga SF  Nelson CA  Fox NA  Zeanah CH 《Child development》2011,82(4):1040-1046

This report examines 174 young children's language outcomes in the Bucharest Early Intervention Project, the first randomized trial of foster placement after institutional care. Age of foster placement was highly correlated with language outcomes. Placement by 15 months led to similar expressive and receptive language test scores as typical age peers at 30 and 42 months. Placement from 15 to 24 months also led to dramatic language improvement. In contrast, children placed after 24 months had the same severe language delays as children in institutional care. Language samples at 42 months confirmed that placement after 24 months led to lower expressive skill.  相似文献   

CHANGING VISIONS OF EXCELLENCE IN ONTARIO SCHOOL POLICY: THE CASES OF LIVING AND LEARNING AND FOR THE LOVE OF LEARNING     

Rosa Bruno‐Jofré  George Hills 《Educational theory》2011,61(3):335-349

In this essay, Rosa Bruno‐Jofré and George Hills examine two major Ontario policy documents: 1968's Living and Learning and 1994's For the Love of Learning. The purpose is, first, to gain insight into the uses of the term “excellence” in the context of discourse about educational aims and evaluation, and, second, to explore how these uses may have changed over time. Bruno‐Jofré and Hills employ the conceptual framework developed by Madhu Prakash and Leonard Waks to elucidate the varied notions of excellence contained in the two reports. Bruno‐Jofré and Hills argue that Living and Learning is an eclectic report that creates continuity by aligning itself with the pedagogically progressive tradition in Ontario; that propounds a holistic conception of excellence centered on the all‐around development of the self; and that seeks simultaneously to secure a sense of being Canadian while dealing with rapidly emerging social fragmentation. For the Love of Learning, in contrast, attempts to combine a technical view of excellence in education (stressing various literacies and skills as measurable indicators) with the principles of caring and the goals of social responsibility. Each report can be seen as an attempt to respond to the expectations of a population that had become increasingly diverse in the interval between the two reports. What is cause for concern in terms of policymaking, Bruno‐Jofré and Hills conclude, is the turn away from broader, more comprehensive and coherent views of excellence in education toward narrower and more fragmented accounts that are preoccupied with various types of literacy or loosely related vocational and other skills. The effect of this shift is to leave educational policy and practice in the schools essentially rudderless.  相似文献   

Kindergarten children's growth trajectories in reading and mathematics: who falls increasingly behind?     

Morgan PL  Farkas G  Wu Q 《Journal of learning disabilities》2011,44(5):472-488

The authors used a large sample of children (N ≈ 7,400) participating in the Early Childhood Longitudinal Study--Kindergarten Cohort (ECLS-K) to estimate kindergarten children's academic achievement growth trajectories in reading and mathematics. The authors were particularly interested in whether the growth trajectories of children with learning disabilities (LD) or speech language impairments (SLI)--as well as those of other groups of children--were consistent with a cumulative or compensatory developmental cycle. Both LD and SLI children displayed significantly lower levels of kindergarten reading achievement than nondisabled children. However, and over the subsequent 5 years of elementary school, only children with SLI lagged increasingly behind nondisabled peers in their reading skills growth. The authors observed a different pattern for mathematics achievement. Children with LD, but not SLI, lagged increasingly behind nondisabled children in their mathematics skills growth. The authors also observed some consistency in "poor-get-poorer" effects across reading and mathematic achievement for additional population subgroups. Those kindergarten children who were from lower socioeconomic status families, who were African American, and who more frequently displayed learning-related behavior problems initially had lower levels of reading and mathematics achievement and also lagged increasingly behind in their acquisition of these skills over time. Some groups of children, including those with SLI, experience a cumulative rather than a compensatory cycle of achievement growth.  相似文献   

VI. SENSITIVE PERIODS     

Charles H. Zeanah  Megan R. Gunnar  Robert B. McCall  Jana M. Kreppner  Nathan A. Fox 《Monographs of the Society for Research in Child Development》2011,76(4):147-162

This chapter reviews sensitive periods in human brain development based on the literature on children raised in institutions. Sensitive experiences occur when experiences are uniquely influential for the development of neural circuitry. Because in humans, we make inferences about sensitive periods from evaluations of complex behaviors, we underestimate the occurrence of sensitive periods at the level of neural circuitry. Although we are most interested in complex behaviors, such as IQ or attachment or externalizing problems, many different sensitive periods at the level of circuits probably underlie these complex behaviors. Results from a number of studies suggest that across most, but not all, domains of development, institutional rearing limited to the first 4–6 months of life is associated with no significant increase risk for long‐term adverse effects relative to noninstitutionalized children. Beyond that, evidence for sensitive periods is less compelling, meaning that “the earlier the better” rule for enhanced caregiving is a reasonable conclusion at the current state of the science.  相似文献   

Study of resonance-cone propagation in truncated hyperbolic metamaterial grids using transmission-line matrix simulations     

Omar F. Siddiqui  George V. Eleftheriades 《Journal of The Franklin Institute》2011,348(7):1285-1297

In this paper, we utilize transmission-line matrix simulations to study the electromagnetic properties of hyperbolic metamaterial grids, which are synthesized by arranging unloaded transmission lines over electrical ground planes, such that the unit cells are rectangular in shape. The hyperbolic grids support Bragg and Hyperbolic resonant modes that have rectangular and hyperbolic dispersion surfaces, respectively. We demonstrate the formation of these resonant modes in the hyperbolic grids and their refraction, and spatial scanning properties via circuit simulations. The simulation results are compared with experimental results of a two-layer anisotropic hyperbolic metamaterial.  相似文献   

Muscle metabolism and performance improvement after two training programmes of sprint running differing in rest interval duration     

Saraslanidis P  Petridou A  Bogdanis GC  Galanis N  Tsalis G  Kellis S  Mougios V 《Journal of sports sciences》2011,29(11):1167-1174

Repeated-sprint training often involves short sprints separated by inadequate recovery intervals. The effects of interval duration on metabolic and performance parameters are unclear. We compared the effects of two training programmes, differing in rest interval duration, on muscle (vastus lateralis) metabolism and sprint performance. Sixteen men trained three times a week for 8 weeks, each training session comprising 2-3 sets of two 80-m sprints. Sprints were separated by 10 s (n = 8) or 1 min (n = 8). Both training programmes improved performance in the 100-, 200-, and 300-m sprints, but the improvement was greater in the 10-s group during the final 100 m of the 200- and 300-m runs. Independent of interval duration, training mitigated the drop of muscle ATP after two 80-m sprints. The drop in phosphocreatine and the increases in glucose-6-phosphate and fructose-6-phosphate after two 80-m sprints were greater in the 10-s group. In conclusion, training with a limited number of repeated short sprints (≤10 s) may be more effective in improving speed maintenance in 200- and 300-m runs when performed with a 1:1 rather than a 1:6 exercise-to-rest ratio. This may be due to a greater activation of glycolysis caused, in part, by the limited resynthesis of phosphocreatine during the very short rest interval.  相似文献