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971.
The ability of parenting stress to predict observed and reported maternal behaviors was explored. Fifty-eight low income women participated with their 3- to 7-year- old children. Thirty of the women were also currently residing in a shelter for battered women. Mothers completed questionnaires and interviews designed to assess parenting stress, maternal adjustment, and marital relationship. Mothers also completed a computer simulation concerning their responses to 10 typical child behaviors. Mother and child were then observed in a 15-minute observation designed to illicit mild maternal stress. Multiple regression and partial correlation analyses indicated that parenting stress predicts maternal use of positive behaviors such as affection and proaction as well as negative behaviors such as prohibition. Results are discussed in terms of the need to develop a model for understanding the impact of parenting stress on childrearing behavior.  相似文献   
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This study tested the pathways supporting adolescent development of prosocial and rebellious behavior. Self-report and structural brain development data were obtained in a three-wave, longitudinal neuroimaging study (8–29 years, N = 210 at Wave 3). First, prosocial and rebellious behavior assessed at Wave 3 were positively correlated. Perspective taking and intention to comfort uniquely predicted prosocial behavior, whereas fun seeking (current levels and longitudinal changes) predicted both prosocial and rebellious behaviors. These changes were accompanied by developmental declines in nucleus accumbens and medial prefrontal cortex (MPFC) volumes, but only faster decline of MPFC (faster maturity) related to less rebellious behavior. These findings point toward a possible differential susceptibility marker, fun seeking, as a predictor of both prosocial and rebellious developmental outcomes.  相似文献   
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This work describes the development of a prototypic microfluidic platform for the generation of stepwise concentration gradients of drugs. A sensitive apoptotic analysis method is integrated into this microfluidic system for studying apoptosis of HeLa cells under the influence of anticancer drug, etoposide, with various concentrations in parallel; it measures the yellow fluorescent protein∕cyan fluorescent protein fluorescence resonance energy transfer (FRET) signal that responds to the activation of caspase-3, an indicator of cell apoptosis. Sets of microfluidic valves on the chip generate stepwise concentration gradient of etoposide in various cell-culture microchambers. The FRET signals from multiple chambers are simultaneously monitored under a fluorescent microscope for long-time observation and the on-chip results are compared with those from 96-well plate study and the methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. The microfluidic platform shows several advantages including high-throughput capacity, low drug consumption, and high sensitivity.  相似文献   
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New displays, galleries and exhibitions in museums and galleries are increasingly subject to summative evaluations, wide-ranging investigations that examine how visitors respond to and engage with particular initiatives. These evaluations provide insights into the behaviour and attitudes of visitors and the ways in which particular exhibitions, exhibits and information resources facilitate engagement, participation and learning. Unfortunately, however, summative evaluation has relatively little impact either on the particular initiative or more generally in contributing to our knowledge of visitor behaviour and understanding of best practice. In this paper, we suggest that the relative lack of impact of summative evaluation is not primarily due to any methodological shortcomings or the idiosyncrasies of some of the approaches that are used. Rather, the organisational and institutional context in which summative evaluation is commissioned, undertaken and received can impose contradictory demands and undermine the opportunity of learning from and applying the findings of evaluation.  相似文献   
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