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Leta Hunt Project Manager/Librarian of the ISLA project Lucy S. Wegner Director 《The Journal of Academic Librarianship》1996,22(6):440-449
This article discusses the role of end users in the design of a multi-format digital library project (ISLA) being developed at the University of Southern California Library for the study of the Los Angeles region. ISLA focuses on the specific needs of cross-disciplinary research involving large urban regions. 相似文献
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Requests for monographs generated within an interlibrary loan network are analyzed for half-life statistics. It is suggested that demand represents use of the literature more completely than satisfied requests or circulation statistics. Demand in this study is characterized as either regional demand or statewide demand and is related to the level of the network where final processing of the request occurs. A negative exponential distribution is found to adequately characterize both levels of demand as a function of publication date for four subject categories. Corrected demand data is obtained by removing the growth rate of most of the available literature represented by American book publisher output. Based on over 10,000 interlibrary loan requests, negative exponential distributions describe the raw data as well as the corrected data. A shorter half-life was found for regional library demand (10.47 yr) than that found for statewide library demand (15.75 yr). Applying the correction factor to reflect the growth rate of the available literature tends to increase the half-life when compared to the raw data, and changes the ordering of subject classes with respect to ascending half-lives. 相似文献
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Margetic S 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):49-62
Inflammation and haemostasis are interrelated pathophysiologic processes that considerably affect each other. In this bidirectional relationship, inflammation leads to activation of the haemostatic system that in turn also considerably influences inflammatory activity. Such, the haemostatic system acts in concert with the inflammatory cascade creating an inflammation-haemostasis cycle in which each activated process promotes the other and the two systems function in a positive feedback loop. The extensive crosstalk between immune and haemostatic systems occurs at level of all components of the haemostatic system including vascular endothelial cells, platelets, plasma coagulation cascade, physiologic anticoagulants and fibrinolytic activity. During inflammatory response, inflammatory mediators, in particular proinflammatory cytokines, play a central role in the effects on haemostatic system by triggering its disturbance in a number of mechanisms including endothelial cell dysfunction, increased platelet reactivity, activation of the plasma coagulation cascade, impaired function of physiologic anticoagulants and suppressed fibrinolytic activity. The two examples of pathophysiologic processes in which the tight interdependent relationship between inflammation and haemostasis considerably contribute to the pathogenesis and/or progression of disease are systemic inflammatory response to infection or sepsis and acute arterial thrombosis as a consequence of ruptured atherosclerotic plaque. Close links between inflammation and haemostasis help explain the prothrombotic tendency in these two clinical conditions in which inflammation shifts the haemostatic activity towards procoagulant state by the ability of proinflammatory mediators to activate coagulation system and to inhibit anticoagulant and fibrinolytic activities. This review summarizes the current knowledge of the complex interactions in the bidirectional relationship between inflammation and haemostasis. 相似文献