Relative bioavailability and pharmacokinetic comparison of two different enteric formulations of omeprazole     

Jian Liu  Jian-zhong Shentu  Li-hua Wu  Jing Dou  Qi-yang Xu  Hui-li Zhou  Guo-lan Wu  Ming-zhu Huang  Xing-jiang Hu  Jun-chun Chen 《Journal of Zhejiang University. Science. B》2012,13(5):348-355

In order to comply with the requirements for a drug listed in China, the study was developed to compare the pharmacokinetics and relative bioavailability of two different enteric formulations of omeprazole (OPZ) in healthy Chinese subjects. A total of 32 volunteers participated in the study. Plasma concentrations were analyzed by nonstereospecific liquid chromatography/tandem mass spectrometric (LC-MS/MS) method. After administration of a single 40-mg dose of the two OPZ formulations, the comparative bioavailability was assessed by calculating individual AUC_0−t (the area under the concentration-time curve from time zero to the last measurable concentration), AUC_0−∞ (the area under the concentration-time curve extrapolated to infinity), C _max (the maximum observed concentration), and T _peak (the time to C _max) values of OPZ, 5-hydroxyomeprazole (OH-OPZ), and omeprazole sulfone (OPZ-SFN), respectively. The 90% confidence intervals (CIs) of AUC_0−t , AUC_0−∞, and C _max were 85.4%–99.0%/88.8%–98.6%/87.6%–99.4%, 85.5%–99.2%/89.0%–98.6%/88.5%–101.3%, and 72.3%–87.6%/79.6%–91.1%/88.4%–99.1% for OPZ/OH-OPZ/OPZ-SFN, respectively, and T _peak values did not differ significantly. In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers met the Chinese bioequivalance standard to the reference formulation based on AUC, C _max, and T _peak.  相似文献   

The materials and techniques used in the paintings of Francis Bacon (1909–1992)     

《文物保护研究》2013,58(4):207-217

Abstract

Materials from 38 paintings by Francis Bacon (1909–1992), including 21 complete works and 17 partially destroyed canvases are investigated. Observations are made of the artist's technique and details are compiled of the supports used. Samples of paint and priming were taken for analysis using polarized light microscopy, Fourier transform infrared spectroscopy (FTIR), gas chromatography–mass spectrometry (GC–MS), pyrolysis–GC–MS (Py–GC–MS), and scanning electron microscopy coupled with energy dispersive X-ray analysis (SEM–EDX). Analysis of priming layers appears to show that the priming composition correlates well with particular ranges of dates. A fairly limited range of materials are found, with many of the same pigments found in works spanning Bacon's career, though other pigments were introduced at different stages in his career. Oil paints were used consistently for the painting of figures, but household paints were increasingly used in backgrounds from the 1960s onwards. A variety of different synthetic media are found in later works, including household acrylic paints and spray paints. Increased knowledge of Bacon’s materials is expected to be of great value to conservators caring for the work of this highly significant artist, and is already helping in the authentication of works attributed to him.  相似文献   

薄荷精油化学成分的分析   总被引：4，自引：0，他引：4  

李铁纯  张捷莉 《鞍山师范学院学报》2000,2(1):89-91

对辽宁产薄荷采用同时蒸馏萃取法提取精油,得率约为3．0％,并结合GC／MS法对精油化学成分进行了鉴定,共鉴定了21种化学成分。  相似文献   

国家创新系统中的图书馆   总被引：5，自引：0，他引：5  

黄颖  陈兰 《图书情报工作》2001,45(6):13-15

应用国家创新系统理论,分析图书馆在国家创新系统中的战略机会和战略发展问题。  相似文献   

在MS SQL Server应用系统中实施数据完整性约束     

李军 《陕西理工学院学报(社会科学版)》2001,19(6):17-21

介绍了在MS SQL Server数据库应用系统中实施数据库表的实体完整性和参照完整性约束;独立于表的规则、缺省,索引和触发器约束,客户端应用程序的数据完整性约束.同时阐述了在应用系统中实施数据完整性约束的基本策略,并给出了实施数据完整性约束的实例.  相似文献   

流媒体服务在IPv6网络中的应用     

麻书钦 《广东技术师范学院学报》2006,(6):44-46

IPv6,下一代互联网的关键技术,随着科技的发展已经开始被越来越多的国家应用于真正网络中,流媒体服务随着宽带的发展在网络中所占的地位也变得越来越重要,网络电视,网络会议,VOD、网络电话等网络应用都少不了流媒体.本文主要讨论流媒体服务在IPv6网络中是如何应用的.  相似文献   

基于MS Agent的英语LOD系统设计     

胡芳芳  倪应华 《金华职业技术学院学报》2006,6(6):74-76

本文介绍了一种通过Agent代理技术实现英语听力点播的方法,详细介绍了系统流程、关键技术以及具体实现方法。该方法直接将英语听力文本语料通过TextToSpeech技术直接转换成语音输出。  相似文献   

静态顶空-气质联用法快速测定油漆中苯系物   总被引：4，自引：0，他引：4  

喻文娟  刘玉敏  苏明明  王叶菲  曹菁 《实验室研究与探索》2010,29(1)

采用静态顶空-气相色谱质谱联用法(HS-GC/MS),对不同油漆中苯及同系物进行含量测定。在样品分散剂DMSO、平衡温度120℃、平衡时间60 min等优化的静态顶空进样条件下,进行了方法学的考察。苯及同系物的线性良好,回归方程相关系数大于0.99,3个不同浓度水平的加标回收率大于70%。实验结果表明,样品中苯及同系物含量的相对标准偏差(RSD)10%,数据准确、重复性好。同时,HS-GC/MS快速、简便、可靠,是检测油漆等化工品中苯及同系物含量的有效方法。  相似文献   

常见纺织油剂的结构及组分分析     

温正如  申屠鲜艳  汪雪  肖珊美 《金华职业技术学院学报》2010,10(3):41-45

采用硅胶柱色谱法分离纺织油剂中的各组分,利用红外光谱法和质谱法对所分离组分进行结构鉴定,确定该样品的化学组成,并用重量法对其含量进行定量分析。  相似文献   

金银花中挥发性成分的GC／MS分析及其指纹图谱的建立     

宋兴良  吕莉 《临沂师范学院学报》2010,32(3):96-100

研究了金银花挥发油的提取方法及其GC／MS的分析方法,通过气相色谱一质谱联用技术（GC—MS）分析了金银花挥发油的主要化学成分及其相对含量．建立了金银花的GC／MS指纹图谱,并利用该指纹图谱比较了两个不同产地金银花的质量情况．气相色谱／质谱法的实验条件是：毛细管柱为Rtx（30m×0．25mm×0．25μm）;进样口温度为250℃;程序升温为60℃至150℃（5℃／min）,150℃至250℃（8℃／min）;60℃以后停3min,150℃以后停8min,250℃以后停5min,E1源温度200℃,离子源接口温度250℃．结果表明,金银花挥发油的提取率随地区的不同而不同,采用GC／MS法控制药材的指纹图谱,该方法重现性好、准确度高,可用于金银花的质量评价．  相似文献