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31.
Bingyu SUN Yongqiang LIU Danhua HE Jinke LI Jiawei WANG Wulin WENS Ming HONG 《Journal of Zhejiang University. Science. B》2021,22(3):190-203
The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments.Most current chemotherapy agents have significant cytotoxicity,which leads to devastating adverse effects and results in a substandard quality of life,including increased daily morbidity and premature mortality.The death receptor of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells.However,various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways.Therefore,it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL,and to reinforce TRAIL’s ability to induce tumor cell apoptosis.In recent years,traditional Chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines.This review aims to collate information about Chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL’s ability to induce apoptosis.We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anticancer drugs for human cancer treatment.This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed."TRAIL sensitize"and"Chinese medicine"were the search keywords.We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis.The name of each plant was validated using certified databases such as The Plant List.This study indicates that TRAIL can be combined with different Chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis.It also demonstrates that the active ingredients of traditional Chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis.This provides useful information regarding traditional Chinese medicine treatment,the development of TRAIL-based therapies,and the treatment of cancer. 相似文献
32.
Gülsen Yilmaz Fatma Meriç Yilmaz Mehmet Senes Dogan Yucel 《Indian journal of clinical biochemistry : IJCB》2007,22(1):52-56
Serum tumor markers may be requested inappropriately by clinicians. In this retrospective study, we aimed to investigate the
appropriateness of TM requests in our hospital. Patients in the study were identified from the TM requests for 3 months between
June–August 2004, using the laboratory database. A total of 2249 patients (1351 men, 898 women) were included in the study
and there were 6570 TM requests. The number of requests were 1050 (16%) for Carbohydrate Antigen 19-9, 993 (15.1%) for Cancer
Antigen 125, 941 (14.3%) for Prostate Specific Antigen, 921 (14%) for free PSA, 925 (14.1%) for Cancer Antigen 15-3, 788 (12%)
for Alphafetoprotein, 730 (11.1%) for Carcinoembryonic Antigen and 222 (3.4%) for AFP/Human Chorionic Gonadotrophin. Our findings
support the idea that for the evidence-based use of TM requests the education of clinical staff is required. Clear clinical
guidelines including recommendations about the appropriate use of TM can be useful for this education process. Careful audit
studies are also useful to determine the impact of these guidelines on the practice of evidence-based laboratory medicine. 相似文献
33.
Pushpa P. Durgawale P. S. Shukla Shubhangi D. Sontakke P. G. Chougule 《Indian journal of clinical biochemistry : IJCB》2001,16(1):110-112
In the present study the property of lectin agglutination in blood on normal and different cancer patients has been observed.
The purifiedSynadenium grantii root lectin was non blood group specific and its utility as a diagnostic tool in malignancy was studied. Hemagglutination
(units/ml) of red blood cells of different types of cancer was compared with the normal control's red blood cells. Out of
113 total cancer patients, only a group of 29 breast cancer patients showed significant increase in titre value (P<0.05) compared
to normal control. 相似文献
34.
Di JZ Han XD Gu WY Wang Y Zheng Q Zhang P Wu HM Zhu ZZ 《Journal of Zhejiang University. Science. B》2011,12(10):805-811
Global DNA hypomethylation has been associated with increased risk for cancers of the colorectum, bladder, breast, head and
neck, and testicular germ cells. The aim of this study was to examine whether global hypomethylation in blood leukocyte DNA
is associated with the risk of hepatocellular carcinoma (HCC). A total of 315 HCC cases and 356 age-, sex- and HBsAg status-matched
controls were included. Global methylation in blood leukocyte DNA was estimated by analyzing long interspersed element-1 (LINE-1)
repeats using bisulfite-polymerase chain reaction (PCR) and pyrosequencing. We observed that the median methylation level
in HCC cases (percentage of 5-methylcytosine (5mC)=77.7%) was significantly lower than that in controls (79.5% 5mC) (P=0.004, Wilcoxon rank-sum test). The odds ratios (ORs) of HCC for individuals in the third, second, and first (lowest) quartiles
of LINE-1 methylation were 1.1 (95% confidence interval (CI) 0.7–1.8), 1.4 (95% CI 0.8–2.2), and 2.6 (95% CI 1.7–4.1) (P for trend <0.001), respectively, compared to individuals in the fourth (highest) quartile. A 1.9-fold (95% CI 1.4–2.6) increased
risk of HCC was observed among individuals with LINE-1 methylation below the median compared to individuals with higher (>median)
LINE-1 methylation. Our results demonstrate for the first time that individuals with global hypomethylation measured in LINE-1
repeats in blood leukocyte DNA have an increased risk for HCC. Our data provide the evidence that global hypomethylation detected
in the easily obtainable DNA source of blood leukocytes may help identify individuals at risk of HCC. 相似文献
35.
GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola 《Journal of Zhejiang University. Science. B》2007,8(4)
Hepatocellular carcinoma (HCC) remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. 相似文献
36.
Influence of CO2 pneumoperitoneum on intracellular pH and signal transduction in cancer cells 总被引：17，自引：0，他引：17
Object: The authors studied the influence of CO2 pneumoperitoneum on intracellular pH and signal transduction arising from cancer cell multiplication in laparoscopic tumor operation. Method: They set up a simulation of pneumoperitoneum under different CO2 pressure, and then measured the variation of intracellular pH (pHi) at different time and the activity of protein kinase C (PKC) and protein phosphatase 2a (PP2a) at the end of the pneumoperitoneum. After 1 week, the concentration of cancer cells in the culture medium was calculated. Result: When the pressure of CO2 pneumoperitoneum was 0, 10, 20, 30 mmHg respectively, the average pHi was 7.273, 7.075, 6.783, 6.693 at the end of the pneumoperitoneum; PKC activity was 159.4, 168.5, 178.0, 181.6 nmol/(g-min) and PP2a was 4158.3,4066.9, 3984.0, 3878.5 nmol/(g-min) respectively. After 1 week, the cancer cells concentration was 2.15×105, 2.03×105, 2.20×105, 2.18×105 L-1. Conclusion: CO2 pneumoperitoneum could promote acidosis in cancer cells, inducing the activation of protein kinase C and deactivation of protein phosphatase 2a, but it could not accelerate the mitosis rate of the cancer cells. 相似文献
37.
目的:探讨卵巢上皮癌组织中环氧合酶-2(COX-2)表达及其与微血管密度(MVD)的关系。方法:应用免疫组织化学技术检测65例卵巢上皮癌组织和18例正常卵巢组织中COX-2的表达,并以抗CD34抗体标记微血管内皮细胞测定MVD。结果:卵巢上皮癌组织COX-2表达阳性的比例为73.8%,显著高于正常卵巢组织COX-2表达阳性的比例11.1%(P<0.01)。COX-2阳性表达的卵巢上皮癌组织中的MVD(57.8±18.6)明显高于阴性表达者(37.4±11.2)(P<0.01)。结论:COX-2在卵巢上皮癌组织中高表达,COX-2可促进肿瘤血管生成。 相似文献
38.
Exercise can enhance motivation to change lifestyle behaviors, improve aerobic fitness, improve physical function, control fatigue, and enhance quality of life. Studies have demonstrated the benefits to be gained from physical exercise, highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer. However, the correlation between physical exercise and carcinogenesis is easily overlooked, and exercise interventions are not routinely provided to patients with cancer, especially those with advanced cancer. In this article, we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages. Moreover, the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed. In conclusion, physical exercise should be considered as an important intervention for preventing and treating cancer and its complications. 相似文献
39.
Recent research by communication scholars has investigated the dynamics of abusive spousal relationships (Chandler, 1986; Infante, Chandler, & Rudd, 1989; Infante, Chandler‐Sabourin, Rudd, & Shannon, 1990; Rancer & Niemasz, 1988; Rudd, Burant, & Beatty, 1994; Sabourin, Infante, & Rudd, 1993). Infante and his colleagues have suggested that those involved in violent relationships communicate differently with their partners than those involved in nonviolent relationships. Based on this prior research, it seems important for communication scholars to further investigate the communication behaviors of individuals involved in violent relationships. This current study seeks to advance the family violence research by comparing the types of compliance‐gaining strategies that battered and non‐battered women report using during their disputes. 相似文献
40.
ABSTRACTLong-term survivors of cancer (LTS) are a growing population whose needs differ significantly from patients undergoing cancer treatment. Many LTS suffer from late effects of cancer treatments or symptoms that persist after treatment concludes or appear following remission. This study explored the relationship between LTS perceptions of quality of life with late effects and perceptions of patient self-advocacy through quantitative and qualitative analyses. A negative statistical relationship emerged between the variables. LTS median self-advocacy scores were quite high, reflecting their preference for health-care providers who listen actively, understand patient needs, are knowledgeable and compassionate, and utilize joint decision making. 相似文献