mtDNA analysis of the human remains buried in the sarcophagus of Federico II     

Alfredo Salerno  Giampietro Lago  Andrea Berti  Francesco Calì  Mario Mirisola  Patrizia Carta  Carmen Ferro  Valentino Romano   《Journal of Cultural Heritage》2005,6(4):313-319

The sarcophagus containing the remains of Federico II, located in the Cathedral of Palermo (Sicily, Italy), was opened on 1998 to perform a multidisciplinary survey [1]. Next to the remains of Federico II and in close contact with them were laying two other skeletons belonging, according to historical records, to Pietro II di Aragona and to an anonymous person (“The Third Individual”), probably a woman. The bones appeared severely deteriorated. Chemical analysis performed on bone samples excluded that the bodies underwent some kind of embalming process. The analysis of mtDNA from bone samples taken from the three skeletons was successful in only one of the two labs involved. The HVR1-mtDNA sequence (region: from nt 16,035 to nt 16,395), obtained from the bone samples of Federico II and “The Third Individual” appear identical but bear double peaks at the same nucleotide positions, suggesting mixing (i.e. contamination) of different mtDNA types. The HVR1 sequence obtained from the bone sample of Pietro II di Aragona does not present double peaks and differ from the Cambridge Reference Sequence (CRS) at six nucleotide positions. Cloning experiment of the Federico II amplicon demonstrated that the mixed mtDNA types are only two: one identical to CRS, the other identical to the sequence of Pietro II di Aragona. A reconstruction of these data are proposed in the Discussion. Due to the problematic context in which this study was carried out (mixed and deteriorated biological material, failure to replicate results in two different labs), our results and reconstruction can only be offered on a tentative basis. It is hoped that the data presented in this study will reveal useful, for future comparison, if further molecular genetics research will be carried out on the royal dynasties that ruled Sicily in the early centuries of the past millennium.  相似文献   

An Exercise to Introduce Power     

Edith Seier  Yali Liu 《Teaching Statistics》2013,35(1):53-56

In introductory statistics courses, the concept of power is usually presented in the context of testing hypotheses about the population mean. We instead propose an exercise that uses a binomial probability table to introduce the idea of power in the context of testing a population proportion.  相似文献   

基于知识图谱的近10年国际电子政务研究进展分析     

董伟  朱小梅  徐少同 《图书情报工作》2012,56(13):17-23

在收集WOS数据库中近10年国际电子政务研究领域相关文献的基础上,借助CiteSpaceⅡ,首先对研究文献的时空分布与核心作者分布等进行分析,然后通过对研究热点的发现以及相应研究主题的聚类分析,将国际电子政务的研究进行维度划分,最后在已有研究主题聚类分析的基础上进行研究演进的分析。  相似文献   

非书资料在ILASⅡ系统中的编目探讨     

赖碧淡 《大学图书情报学刊》2005,23(6):36-38

文章从非书资料的编目现状入手,结合ILASⅡ系统的编目功能,分析影响非书资料编目的主要原因及解决办法,并对完善非书资料编目规则及条例提出建议.  相似文献   

MTHFR (Ala 222 Val) polymorphism and AMI in patients with type II diabetes mellitus     

T. Angeline  G. Thiruvarutselvi  W. Isabel  Rita Mary Aruna  Rama Devi  Nirmala Jeyaraj 《Indian journal of clinical biochemistry : IJCB》2009,24(2):137-141

The prevalent Ala222Val single nucleotide polymorphism of the MTHFR gene has been shown to be associated with type II diabetes. The objective of the present study was to find out whether there is genetic predisposition for development of acute myocardial infarction in type II diabetes mellitus among South Indian Tamil population. PCR-based restriction enzyme analysis was performed in DNA isolated from 120 acute myocardial infarction patients with diabetes mellitus and 100 non diabetic healthy individuals with no documented cardiovascular diseases. The results indicate that the MTHFR 677TT genotype is absent in both case and controls. The MTHFR 677CT genotype was observed among 32 (26.7 %) cases and 20 (20%) controls and the MTHFR 677CC genotype among 88 (73.3%) cases and 80 (80%) controls. The allelic frequencies were in accordance to Hardy Weinberg equilibrium. There was no statistical difference in genotype distribution between cases and controls. In conclusion, we suggest that the analysis of MTHFR genotyping for C677T polymorphism alone need not be considered to find out whether there is genetic predisposition for development of acute myocardial infarction in type II diabetes mellitus among South Indian Tamil population.  相似文献   

产学合作中的知识生产效率——基于“模式Ⅱ”的实证研究          下载免费PDF全文

肖丁丁  朱桂龙 《科学学研究》2012,30(6):895-903

 本文利用1998-2008年中国29个省市高校与企业的面板数据,以产学联合申请专利数为产出变量,通过构建随机前沿知识生产函数,探究了“模式Ⅱ”情境下应用导向、跨学科研究、参与者异质性、组织多样性对知识生产效率的影响,并对比分析了区域间知识生产的平均效率及影响因素的边际效应。研究表明：我国区域知识生产效率水平的格局为：东部＞中部＞西部;“模式Ⅱ”情境下企业的人才与资金投入对知识生产有显著的正向影响,而高校知识存量对产学合作中的知识生产贡献度更高,并且该过程具有规模报酬递减的属性;应用导向等影响因素对知识生产效率均有显著的正向影响,但是存在区域与时效上的差异性,应用导向与参与者异质性对东部地区的边际影响较大,东部地区企业参与知识生产的边际效果高于中西部地区,政府介入产学合作对中西部地区知识生产具有长效的正向影响。  相似文献   

Moderate-Intensity Oxygen Uptake Kinetics: Is a Mono-Exponential Function Always Appropriate to Model the Response?     

Julian Dale 《Research quarterly for exercise and sport》2018,89(3):309-321

  相似文献   

Der Leiter des Fachhochschul-Kollegiums     

Christian Butschek 《Zeitschrift für Hochschulrecht, Hochschulmanagement und Hochschulpolitik: zfhr》2009,8(2):50-59

Ebenso wie beim Fachhochschul-Kollegium selbst, stellen sich beim Leiter des Fachhochschul-Kollegiums eine Reihe von grundlegenden Rechtsfragen, insbesondere zu seiner verfassungs- und hochschulrechtlichen Stellung, seiner Wahl bzw Abberufung, seinen Aufgaben hoheitlicher und nichthoheitlicher Natur, zu verfahrensrechtlichen Problemen und seinem Verhältnis zum Erhalter. Soweit bei dem gegebenen, spärlichen Auslegungsmaterial möglich, wird versucht, Lösungsansätze zu den aufgezeigten Rechtsproblemen zu erarbeiten.  相似文献   

“My job was to teach”: educators’ memories of teaching in British Columbia during World War II     

Helen Raptis 《Paedagogica Historica: International Journal of the History of Education》2018,54(4):447-467

Substantial historical research indicates that during World War II Canadian schools were considered optimal sites for fostering nationalistic sentiments in teachers and learners. Policymakers directed educators and students to collect scrap metals, purchase war savings certificates, salute the flag, and undertake marching drills. These wide-reaching directives give the impression that schools were considerably reshaped during the war. Nevertheless, since much of the literature has used official information sources, such as curriculum documents and government missives, it is unclear to what extent teachers implemented such directives. No Canadian scholarship has tapped the memories of former teachers to determine their compliance in promoting nationalistic sentiments and activities. Nor have existing histories categorised activities by geographic area (such as rural versus urban; coastal versus inland) or school level (elementary versus secondary). Thus, the “unity of purpose and experience” implied by some of the literature may be overemphasised. This paper challenges the suggestion that throughout Canada all children and teachers in schools fervently engaged in nationalistic behaviour during World War II. To supplement government perspectives found in newspapers, magazines, curricular documents, and other Department of Education sources, I interviewed two dozen teachers who taught in 40 schools throughout British Columbia between 1939 and 1945. Despite policymakers’ intentions, there were many factors influencing schools’ abilities to support the war effort. These included a community’s geographic proximity or access to centres of larger war-related activity, such as munitions factories or collection stations; the values and social circumstances of families and communities; and teachers’ individual preferences, often reflecting their career stage.  相似文献   

ILAS Ⅱ与INTERLIB流通子系统中的几点比较     

胡慧敏 《内蒙古科技与经济》2010,(8):138-139

文章比较了ILAS Ⅱ与INTERLIB在流通外借子系统实际操作中的细微差异,以期图书馆自动化集成系统能进一步得到完善。  相似文献