Overexpression of Aldose Reductase Render Mouse Hepatocytes More Sensitive to Acetaminophen Induced Oxidative Stress and Cell Death     

Munzir M. E. Ahmed  J. A. S. Al-Obosi  H. M. Osman  M. E. Shayoub 《Indian journal of clinical biochemistry : IJCB》2016,31(2):162-170

Acetaminophen (APAP) a commonly used drug for decrease the fever and pain but is capable to induced hepatotoxicity at over dose. This study was carried out to investigate the effect of APAP on the expression of anti-apoptotic and antioxidative defense genes, and whether aldose reductase over-expressing plasmid capable to protect against APAP-induced oxidative stress and cell death. APAP treatment induced oxidative stress and hepatotoxicity, and significantly increased aldose reductase mRNA and protein expression in mouse hepatocyte (AML-12). Unexpectedly, AML-12 cells over-expressing aldose reductase augmented APAP-induced reduction in cell viability, reactive oxygen species (ROS) production, glutathione (GSH) depletion and glutathione S-transferase A2 expression. Moreover, over-expression of aldose reductase potentiated APAP induced reduction on proliferating cell nuclear antigen, B cell lymphoma-extra large (bcl-x_L), catalase, glutathione peroxidase-1 (GPx-1) and abolished APAP-induced B-cell lymphoma 2 (bcl-2) inductions. Further, over-expression of aldose reductase significantly abolished AMP activated protein kinase (AMPK) activity in APAP-treated cells and induced p53 expression. This results demonstrate that APAP induced toxicity in AML-12, increased aldose reductase expression, and over-expression of aldose reductase render this cell more susceptible to APAP induced oxidative stress and cell death, this probably due to inhibition AMPK or bcl-2 activity, or may due to competition between aldose reductase and glutathione reductase for NADPH.  相似文献   

血管内皮生长因子和白细胞介素-12在急性白血病中的表达及临床意义     

高丽君  夏薇  杜冰洋 《中国科学院研究生院学报》2007,24(3):368-371

目的 通过检测急性白血病（AL）患者静脉血清中血管内皮生长因子（VEGF）和 白细胞介素12（IL-12）的含量，探讨VEGF和IL-12在急性白血病中的含量及临床意义。方法 应用定量酶联免疫吸附实验测定10例初诊未治、10例缓解期、5例复发患者和9例正常对照血清中VEGF和IL-12的含量。结果 初诊未治组的VEGF含量（521.06±163.85pg/ml）明显高于缓解组（307.62±55.40pg/ml）及对照组（262.01±141.66pg/ml）（p均<0.05）。对照组的IL-12水平（58.96±38.11pg/ml）与初诊复发组（初诊未治组与复发组的合称32.51±14.58pg/ml）、缓解组（71.67±119.09pg/ml）之间均有显著性差异（p均<0.05）。正常对照组VEGF的含量与IL-12之间存在负相关性。结论 VEGF和IL-12与AL的病情变化有一定的关系。  相似文献   

College selectivity and young adult health behaviors     

Jason M. Fletcher  David E. Frisvold 《Economics of Education Review》2011,30(5):826-837

Large literatures have shown important links between the quantity of completed education and health outcomes on one hand and the quality or selectivity of schooling on a host of adult outcomes, such as wages, on the other hand. However, little research attempts to produce evidence of the link between school quality and health. The paper presents the first evidence in the literature on the potential short and intermediate term effects of attending a selective college on health behaviors during and following college attendance. Using a variety of empirical methods, this paper shows strong evidence that college selectivity reduces tobacco and marijuana use but has small and possibly positive effects on binge drinking. The effects on weight behaviors are suggestive of reduced weight, potentially through diet, but not exercise change.  相似文献   

Poisoning the mind: Arsenic contamination of drinking water wells and children's educational achievement in rural Bangladesh     

M. Niaz Asadullah  Nazmul Chaudhury 《Economics of Education Review》2011,30(5):873-888

Bangladesh has experienced the largest mass poisoning of a population in history owing to contamination of groundwater with naturally occurring inorganic arsenic. Prolonged drinking of such water risks development of diseases and therefore has implications for children's cognitive and psychological development. This study examines the effect of arsenic contamination of tubewells, the primary source of drinking water at home, on the learning outcome of school-going children in rural Bangladesh using recent nationally representative data on secondary school children. We unambiguously find a negative and statistically significant correlation between mathematics scores and arsenic-contaminated drinking tubewells at home, net of the child's socio-economic status, parental background and school specific unobserved correlates of learning. Similar correlations are found for an alternative measure of student achievement and subjective well-being (i.e. self-reported measure of life satisfaction), of the student. We conclude by discussing the policy implication of our findings in the context of the current debate over the adverse effect of arsenic poisoning on children.  相似文献   

The impact of education on health knowledge     

Duha Altindag 《Economics of Education Review》2011,30(5):792-812

The theory on the demand for health suggests that schooling causes health because schooling increases the efficiency of health production. Alternatively, the allocative efficiency hypothesis argues that schooling alters the input mix chosen to produce health. This suggests that the more educated have more knowledge about the health production function and they have more health knowledge. This paper uses data from the 1997 and 2002 waves of the NLSY97 to conduct an investigation of the allocative efficiency hypothesis by analyzing whether education improves health knowledge. The survey design allows us to observe the increase in health knowledge of young adults after their level of schooling is increased by differential and plausibly exogenous amounts. Using nine different questions measuring health knowledge, we find weak evidence that an increase in education generates an improvement in health knowledge for those who ultimately attend college. For those with high school as the terminal degree, no relationship is found between education and health knowledge. These results imply that the allocative efficiency hypothesis may not be the primary reason for why schooling impacts health outcomes.  相似文献   

“十二五”期间区域教育科研发展与创新的思考     

周家荣 《聊城师范学院学报》2011,(2):29-32

教育科研在教育改革与发展中起着基础性、导向性、引领性、战略性等作用。区域教育差异、区域教育科研水平差距的现状迫切需要推进区域教育科研发展与创新。“十二五”期间,区域教育科研要以国家中长期教育改革与发展规划纲要为指导,结合区域教育实际情况,不断提升教育科研的水平与质量;加强教育科研管理,创新机制;突出重点,全面推进;加大经费投入,加强教育科研成果的转化,努力形成区域教育科研的特色和优势。  相似文献   

孔隙分布不均匀性对渗透率影响的MRTLBM法研究     

马斌  史琳  黄超  许强辉 《中国科学院大学学报》2018,35(2):193-199

孔隙率与渗透率是多孔介质非常重要的属性参数,采用MRT LBM研究孔隙率损失与渗透率损失相关性以及同孔隙率异构孔隙对渗透率特性的影响。结果表明：当存在使孔隙率均匀变小的沉积、沉降或结焦等因素时,渗透率损失率是孔隙率损失率的2倍左右;同孔隙率异构多孔体中,渗透率有巨大差异;同孔隙率异构多孔体中最大孔喉最小孔喉比越大渗透率越小;同孔隙率多孔体中迂曲度越大渗透率越小。  相似文献   

建设体育生态城市，实现上海体育“十二五”时期创新驱动、转型发展   总被引：1，自引：1，他引：0       下载免费PDF全文

陈玉忠 《体育科研》2011,32(2):8-12

上海“十二五”规划将建设生态城市列为未来发展目标之一。体育生态是建设生态城市的一个组成部分,契合了当前体育和社会发展的趋势。研究提出应从以下几个路径建设上海体育生态城市,实现上海体育“十二五”时期创新驱动、转型发展：加强体育设施的规划和科学论证,通过生态体育提升上海的“软实力”;倡导全民生态体育理念;形成上海独特的体育自然、人文生态;关注民生,通过生态体育建设推进《全民健身计划》的落实;借鉴国外体育生态建设的经验等。  相似文献   

“十二五”时期河南省新农村武术发展的思考研究     

樊艺勇  王秀荣 《搏击·武术科学》2011,8(2):39-42

社会主义新农村建设是一个全面、系统的工程,体育活动成为衡量新农村建设过程中提高人民生活水平和质量的一个重要举措。在新农村怎样开展好武术活动成为整个＂十二五＂时期河南省新农村体育事业可持续发展的目标,对更好地继承和弘扬中华民族传统文化具有举足轻重的作用,值得引起我们深刻的思考和研究。  相似文献   

关于图书馆“十二五”战略规划的若干思考   总被引：3，自引：0，他引：3  

柯平  贾东琴  李廷翰 《图书馆工作与研究》2011,(3):4-11

"十一五"期间,我国图书馆在经济、法律、信息技术、教育等方面都取得显著成就,为"十二五"战略规划的制定奠定基础。本文在对我国图书馆"十二五"战略规划制定现状与存在问题进行探讨与分析的基础上,从加强图书馆战略规划制定的科学性、加强对图书馆战略规划的分类指导两个方面,为我国图书馆"十二五"战略规划的制定提供理论参考。  相似文献