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101.
Reperfusion is the key strategy in acute ST-segment elevation myocardial infarction (STEMI) care, and it is time-dependent.
Shortening the time from symptom to reperfusion and choosing the optimal reperfusion strategy for STEMI patients are great
challenges in practice. We need to improve upon the problems of low reperfusion rate, non-standardized treatment, and economic
burden in STEMI care. This article briefly reviews the current status of reperfusion strategy in STEMI care, and also introduces
what we will do to bridge the gap between the guidelines and implementation in the clinical setting through the upcoming China
STEMI early reperfusion program. 相似文献
102.
Acute lung injury/acute respiratory distress syndrome （ALI/ARDS）： the mechanism, present strategies and future perspectives of therapies 总被引：5，自引：0，他引：5
Acute lung injury/acute respiratory distress syndrome （ALI/ARDS）, which manifests as non-cardiogcnic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies. 相似文献
103.
Rachita Nanda Pramila K. Mishra U. K. Das S. B. Rout P. C. Mohapatra A. Panda 《Indian journal of clinical biochemistry : IJCB》2004,19(1):93-96
Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one
complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde
level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated
falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin
levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication
with rise of lipid peroxides in falciparum malaria induced acute renal failure cases. 相似文献
104.
目的探讨IL-18／IL-10比值在急性冠脉综合征中的临床意义。方法选取急性冠脉综合征（Acs）患者126例,采用ELISA方法检测全部病例动脉血IL-18与IL-10表达。并随访观察有无心脏事件再发。结果ACS组再次发生心脏事件43例（34％）,83侧（66％）未发生。IL-18／IL-10比值0=0．002）较IL-18（p=0．022）和IL-10（p=0．019）单独评价心脏事件再发更有价值。结论IL-18／IL-10比值可作为预测ACS发生及预后判定的指标;前炎性与抗炎性反应失衡是ACS再发的重要性因素。 相似文献
105.
Christoph Zinner Maximilian Pelka Alexander Ferrauti Tim Meyer Mark Pfeiffer Billy Sperlich 《European Journal of Sport Science》2017,17(10):1304-1310
The aim of the study was to investigate the effects of wearing various levels of compression following repeated and exhausting sprint exercise on variables related to recovery. Twelve well-trained handball players performed three sessions of repeated and exhausting sprint exercise (30?×?30m). Directly after each session the participants wore tights extending from below the hip to the foot with either 0, 10, or 25?mm?Hg of compression onto the thigh and calf muscles. 48?h after the training session all participants performed 5?×?30m sprints and counter movement jumps. Before, directly after, 24?h, and 48?h after the training session venous blood samples were drawn for the determination of creatine kinase (CK), urea, C-reactive protein (CRP). At the same time points, subjective ratings of the Acute Recovery and Stress Scale (ARSS) questionnaires were obtained. The results for plasma concentrations of CK and urea showed ‘likely’ to ‘very, very likely’ beneficial effects for compression garments exerting 10?mm?Hg of compression (p?=?0.06–1.0). With regard to sprint and jump performance no differences were evident between 0, 10, and 25?mm?Hg (p?=?0.07–1.0). In addition, subjective scores from the ARSS did not differ between conditions over time (p?>?0.05). We conclude that the application of 10?mm?Hg leg compression compared to 0 and 25?mm?Hg of compression during 48?h of recovery from repeated and exhausting sprints lowered the plasma concentrations of CK and urea with no improvements in recovery for performance. 相似文献
106.
The purpose of this study is to find out the frequency of TP53 mutations in acute myeloid leukemia (AML) patients and correlate sensitivity of drug response with TP53 mutations. In AML more than 90 % of cases comprise of wild type TP53. 94.2 % of TP53 mutations are found within exon 5–8 of which 73 % are point mutations. TP53 mutations were analysed with high resolution melting curve analysis. We analysed 106 AML samples of which we found nine mutations which represents 8.5 % mutation rate and found one rare SNP. The effect of TP53 mutations were studied on the chemosensitivity of two new drugs AZD115 and RHPS4, an Aurora Kinase B inhibitor and Telomerase inhibitor respectively. Four mutations were found out of 17 for RHPS4 stating significant (p = 0.002) increase in sensitivity and no mutation found in AZD1152 database, but need more study to get definite conclusion. 相似文献
107.
周雪根 《常熟理工学院学报》2009,23(9):119-122
姚栖霞在极为艰难的环境下进行诗歌创作,且成就斐然、迥异庸流,是清初闺秀一特例。姚栖霞作诗重创新,能言前人未经言;诗意、诗境凄清顽艳、情真意切,如猿啼鹤唳,令人不堪卒读,从诗的字里行间可见出女诗人生存状态之艰难和创作状态之呕心沥血。 相似文献
108.
Min Zhang Hao-yu Meng Ying-ming Zhao Zhi-wen Tao Xiao-xuan Gong Ze-mu Wang Bo Chen Zheng-xian Tao Chun-jian Li Tie-bing Zhu Lian-sheng Wang Zhi-jian Yang 《Journal of Zhejiang University. Science. B》2013,14(8):713-720
Slight elevations in cardiac troponin I and T are frequently observed after percutaneous coronary intervention (PCI). Contrast-induced acute kidney injury (CI-AKI) is a complex syndrome induced by exposure to intravascular contrast media (CM). Currently, the relationships between the CM, pre-existing kidney insufficiency, CI-AKI, and myonecrosis after elective PCI are unclear. To investigate the relationship between CI-AKI and post-procedural myonecrosis (PMN) after PCI, we analyzed 327 non-ST-segment elevation acute coronary syndrome subjects undertaking elective PCI. The levels of cardiac troponins (cTns), cTnI and cTnT, at baseline and on at least one occasion 18–24 h after PCI were measured. We also recorded serum levels of creatinine (SCr) and the urine albumin:creatinine ratio (ACR) before coronary angiography, and 24–48 h and 48–72 h after contrast administration. A post-procedure increase in cTns was detected in 16.21% (53/327) of subjects with cTns levels >99th to 599th percentile upper reference limit (URL). Twenty-seven patients (8.26%) developed CI-AKI. CI-AKI occurred more often in subjects with PMN than in those without PMN (20.8% versus 5.8%, respectively, P=0.001). Multiple logistic regression analysis revealed that pre-existing microalbuminuria (MA) was an important independent predictor of PMN (OR: 3.31; 95% CI: 1.26–8.65, P=0.01). However, there was no correlation between the incidence of CI-AKI and PMN (OR: 2.38; 95% CI: 0.88–6.46, P=0.09). We conclude that pre-existing MA was not only an important independent predictor of CI-AKI but also of PMN. 相似文献
109.
Zhi-yu Li Bin Li Yu-lian Wu Qiu-ping Xie 《Journal of Zhejiang University. Science. B》2013,14(6):549-554
Left-sided portal hypertension (LSPH) followed by acute pancreatitis is a rare condition with most patients being asymptomatic. In cases where gastrointestinal (GI) bleeding is present, however, the condition is more complicated and the mortality is very high because of the difficulty in diagnosing and selecting optimal treatment. A successfully treated case with severe GI bleeding by transcatheter splenic artery embolization is reported in this article. The patient exhibited severe uncontrollable GI bleeding and was confirmed as gastric varices secondary to LSPH by enhanced computed tomography (CT) scan and CT-angiography. After embolization, the bleeding stopped and stabilized for the entire follow-up period without any severe complications. In conclusion, embolization of the splenic artery is a simple, safe, and effective method of controlling gastric variceal bleeding caused by LSPH in acute pancreatitis. 相似文献
110.
目的 :建立儿童急性呼吸道感染的PCR检测方法 ,并与常规方法进行比较。方法 :选择编码外膜蛋白P6基因作为靶片段设计引物 ,分别用PCR方法及常规培养法检测 78例急性呼吸道感染儿童。结果 :建立的PCR检测法可以检测 10～ 5 0个流感嗜血杆菌 ;78例急性呼吸道感染儿童中PCR方法检出 4 2株 (5 3.8% ) ,常规培养方法检出 33株 (4 2 .3% ) ,培养法检测阳性者PCR方法均为阳性。PCR方法较培养法有显著性差异。结论 :PCR方法检测呼吸道流感嗜血杆菌感染比常规方法更快速 ,更简便 ,更敏感。PCR方法检测流感嗜血杆菌有可能成为临床流感嗜血杆菌感染诊断的一种实用、理想的方法。 相似文献