Oxidative injury and antioxidant vitamins E and C in Schizophrenia     

Benedicta D'Souza  Vivian D'Souza 《Indian journal of clinical biochemistry : IJCB》2003,18(1):87-90

Susceptibility of Schizophrenic patients to lipid peroxidation relative to healthy control subjects was investigated by measuring the malondialdehyde (MDA) levels in plasma. The main finding was that Schizophrenic patients were more susceptible than control subjects to oxidative damage as evident from increased MDA levels in plasma. Antioxidant levels are also depleted in Schizophrenic patients when compared to normal subjects as evident from decreased levels of vitamins E and C in the plasma. Impaired antioxidant defense and increased lipid peroxidation suggests that treatment with antioxidants (Vitamin E, Vitamin C, beta carotene) at the initial stages of illness may prevent further oxidative injury and deterioration of associated neurological deficits in Schizophrenia.  相似文献   

Evaluation of antioxidant properties of berries     

P. Rani  K. Meena Unni  J. Karthikeyan 《Indian journal of clinical biochemistry : IJCB》2004,19(2):103-110

The present paper focuses on assessing the levels of various enzymatic and non-enzymatic antioxidants in selected berries of Indian sub-continent viz., gooseberry, grapes, orange and tomato. This study has revealed that orange, tomato and grapes possess predominant quantities of enzymatic antioxidants namely SOD, catalase and glutathione peroxidase respectively. The levels of antioxidants analyzed namely reduced glutathione, vitamin C and vitamin A were maximal in grapes, orange and tomato respectively. All the extracts of berries included in the present study inhibited iron inducedin vitro lipid peroxidation in erythrocytes, the extend of inhibition being highest for gooseberry and orange compared to tomato and grapes which could be attributed to their in-built antioxidant system.  相似文献   

太极拳对老年人血脂、血液流变学指标影响的追踪研究   总被引：27，自引：2，他引：25  

王忠山 《天津体育学院学报》1999,14(1):51-53

为探索太极拳对老年人的健身意义,该研究对５３名老年受试者进行了３年追踪研究。结果表明：老年人常年坚持太极拳运动可调节脂类代谢,降低血脂,增加高密度脂蛋白胆固醇以及高密度脂蛋白胆固醇和总胆固醇的比值,增强对心血管系统的保护机制,并可改善以血粘度为代表的血液流变学指标。本研究未见随增龄而血粘度增高的情况  相似文献   

Free radical generation and lipid peroxidation among the dry cell industry workers exposed to carbon     

K. K. Reddy  T. P. K. Reddy  B. V. Somasekharaiah  K. Soorya Kumari 《Indian journal of clinical biochemistry : IJCB》1998,13(1):27-32

A total of 75 healthy male dry cell industry workers exposed to carbon for 5, 8 and 10 years were compared with 48 controls matched for age and economic status with respect to free radical generation, lipid peroxidation and antioxidant levels. Lymphocytes were seperated from the whole blood and used for estimation of free radicals and antioxidants. Plasma lipid peroxidation products were estimated in the form of thiobarbituric acid reactive substances. Significant increase in free radical generation and lipid peroxidation products were observed in carbon exposed population than controls, and the increase was found to be significant with increase in the period of exposure. The levels of antioxidants i.e., superoxide dismutase (SOD) and catalase were found to decrease with the increase in exposure to carbon in industrial workers. These results suggest that exposure to carbon augments free radical generation, lipid peroxidation and promotes decline in antioxidant enzymes.  相似文献   

Role of Oxidative Stress in Various Stages of Psoriasis     

Kadam DP  Suryakar AN  Ankush RD  Kadam CY  Deshpande KH 《Indian journal of clinical biochemistry : IJCB》2010,25(4):388-392

Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently, it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects) and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects. As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and decreased antioxidant potential in psoriasis.  相似文献   

大数据视角下的技术创新路径识别研究   总被引：1，自引：0，他引：1       下载免费PDF全文

周潇  黄璐  马婷婷 《科研管理》2017,38(10):1-9

近年来,以信息技术为代表的新兴技术受到社会各界的广泛关注。然而,由于新兴技术的高度不确定性,如何有效预测并选择合适的商业化路径是目前学术界的研究难点。本文从大数据的角度出发,提出了一种基于文本分析、三元组提取法(SAO)、技术路线图等方法构建而成的"技术创新路径识别模型",对多种异构数据反映的技术发展规律进行探索。该模型在获取研究领域主要技术点的基础上,可以对技术点间动态演化关系以及技术创新路径进行识别。在案例部分,本文以固体脂质纳米粒子(SLN)为例,研究其在医药及化妆品领域的商业化创新路径。研究表明,目前SLN有4条创新路径,其中,在化妆品产业的创新应用是未来市场开发重点。  相似文献   

Ⅱ型糖尿病血脂特点的观察   总被引：2，自引：0，他引：2  

马恩龙  董枫  裘红梅  阎秀丽 《大连大学学报》2003,24(2):89-91

[目的]观察Ⅱ型糖尿病患者血清中总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、载脂蛋白AI(apoAl)、载脂蛋白B(apoB)的浓度与正常人是否有差异,以了解Ⅱ型糖尿病病人的脂类代谢是否有变化以及变化趋势对Ⅱ型糖尿病患者并发症的影响。[方法]对50例临床已确诊的Ⅱ型糖尿病病人和10例健康人分别测定血清中的TC(CHOD-PAP)、TG(GPO-PAP)、HDL-C、LDL-C(直接法-液体双试剂)、apoAl、apoB(免疫比浊法).[结果]部分Ⅱ型糖尿病患者脂类代谢出现异常,其中TC、TG、LDL-C、apoB水平升高,而HDL-C、apoAl降低,这些患者从临床资料看,多数并发大血管病变(冠心病、脑血管病变、肢体的动脉硬化等);部分Ⅱ型糠尿病患者血脂与正常对照组无显著性差异,临床资料显示,这些患者仅为单纯血糖升高,没有并发症出现.[结论]Ⅱ型糖尿病患者的血脂代谢异常与并发症的关系密切.  相似文献   

顽拗性种子低温敏感性与膜脂过氧化的研究     

宋松泉  傅家瑞 《中山大学学报论丛》1992,(3)

木菠萝和黄皮种子在湿藏过程中对低温敏感,随着温度下降,种子的发芽率、萌发指数和超氧物歧化酶的活性下降,丙二醛和脂质氢过氧化物的含量增加。其低温敏感性的原因可能是种子在低温湿藏时,发生膜脂过氧化作用,从而使膜脂丧失,膜的结构和功能受到损伤,种子的生活力丧失。  相似文献   

金樱子多糖体外抗脂质过氧化和红细胞溶血作用研究     

皮建辉  胡朝暾  郑晴  蔡婧 《怀化师专学报》2012,(5):11-15

采用体外实验研究了金樱子多糖（RP）对小鼠肝脏自发性脂质过氧化、H2O2诱导的脂质过氧化、Fe^2＋-Vc诱导的肝线粒体氧化损伤和H2O2诱导的红细胞氧化溶血的影响,比较了金樱子多糖和维生素C（Vc）的抗脂质过氧化作用．结果表明：金樱子多糖具有较强的体外抗脂质过氧化作用,且呈现良好的量效关系;其抗氧化活性明显高于维生素C．  相似文献   

游泳加中药淫羊藿综合疗法对去势大鼠血脂的影响   总被引：2，自引：0，他引：2  

罗丽娜 《吉林体育学院学报》2008,24(4):98-99

妇女绝经后雌激素的缺乏易导致骨质疏松的发生,也易导致绝经期机体脂代谢的紊乱。利用去势大鼠骨质疏松模型,观察了游泳、中药淫羊藿以及游泳加中药等几种防治手段对去势大鼠血脂主要生化指标的影响。结果表明：中药淫羊藿、游泳以及游泳加中药淫羊藿综合疗法等几种防治方法均能通过降低甘油三酯（TG）、低密度脂蛋备（LDL）防治去势大鼠发生高血脂从而避免引发心脑血管疾病,其中游泳加中药淫羊藿综合疗法降脂作用要优于单纯运动及中药组。  相似文献