Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention     

Mohetaboer MOMIN 《Journal of Zhejiang University. Science. B》2012,13(8):638-644

Objective:To investigate the relationship between renal function and clinical outcomes among patients with acute ST-segment elevation myocardial infarction (ASTEMI), who were treated with emergency percutaneous coronary intervention (PCI). Methods: 420 patients hospitalized in Peking University First Hospital, diagnosed with ASTEMI treated with emergency (PCI) from January 2001 to June 2011 were enrolled in this study. Estimated glomerular filtration rate (eGFR) was used as a measure of renal function. We compared the clinical parameters and outcomes between ASTEMI patients combined renal insufficiency and the patients with normal renal function. Results:There was a significant increase in the concentrations of fibrinogen and D-Dimer (P<0.05) and a much higher morbidity of diabetes mellitus in the group of patients with chronic kidney disease (CKD; eGFR<60 ml/(min·1.73 m2)) (P<0.01). CKD (eGFR<60 ml/(min·1.73 m2)) was an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI receiving PCI therapy rapidly (P=0.032, odds ratio (OR) 4.159, 95% confidence interval (CI) 1.127-15.346). Conclusions:Renal insufficiency is an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI treated with primary PCI.  相似文献   

老年慢性肺心病伴发急性心肌梗死的分析     

顾彬 《泰州职业技术学院学报》2005,5(6):45-46

目的探讨老年慢性肺心病伴发急性心肌梗死(AMI)的临床特点.方法对66例老年慢性肺心病伴发AMI的病人(A组)进行分析,并与老年单纯冠心病AMI152例(B组)作比较.结果A组疼痛发生率(45.4%)显著低于B组(83.9%)(p＜0.01),A组急性左心衰、心源性休克发生率显著高于B组,分别为53.1%与25.0%,48.4%与21.7%(p＜0.05),A组病死率(42.4%)显著高于B组(15.7%),肺心病对其伴发AMI的发生部位无影响.结论对老年肺心病患者突然发生的急性左心衰和/或心源性休克应高度警惕伴发AMI的可能.  相似文献   

刺激K-阿片受体诱导的延迟性心肌保护作用     

汤碧娥  宋丽华徐庆 《金华职业技术学院学报》2006,6(3):76-79

本研究利用κ-阿片受体激动剂U50488H预处理(U50488H pretreatment,UP)大鼠,在离体Langendorff灌流心脏和缺血/复灌模型上观察κ-阿片受体激动剂诱发的延迟性心肌保护作用,研究结果表明U50488H预处理大鼠24h后,可明显改善心肌缺血后的复灌期内LVEDP的抬高,以及LVDP和±dP/dtmax的下降(P＜0.05);其作用可被κ阿片受体选择性拮抗剂Nor-binaltorphimine(nor-BNI)所阻断.结论刺激κ-阿片受体诱导了延迟性心肌保护作用.  相似文献   

淋巴液对不同状态大鼠左心室内压的影响     

邱丽颖  吕莉  王德宝  张静  赵兰平 《河北北方学院学报(医学版)》1997,(1)

淋巴液对正常血压大鼠的平均动脉压[MAP]、左室收缩压[LVSP]及左室舒张末压[LVEDP]与生理盐水对照组各项指标相比无显著差异[P>>0.05];而对失血性休克大鼠的MAP、LVSP具有显著回升作用[P<0.01],而对休克时LVEP的恢复无明显作用[P>0.05]。提示:淋巴液只能提高休克心脏的收缩功能,在低血容量情况下对休克心脏的舒张功能无明显影响,对正常心脏的收缩和舒张功能均无明显影响。  相似文献   

Review:Cell therapy in congestive heart failure     

TAO Ze-wei  LI Long-gui 《Journal of Zhejiang University. Science. B》2007,(9)

Congestive heart failure (CHF) has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout (necrosis and apoptosis) plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells (CSCs) within the heart divide symmetrically and/or asym-metrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells (BMCs) to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by dif-ferentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animal CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, pla-cebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction.  相似文献   

Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi’s with Acute Myocardial Infarction     

V. Nagarjuna Maturu  Nidhi Gupta  Gagandip Singh  Kirandip Gill  Yash Paul Sharma  Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(3):248-254

Human serum paraoxonase-1 (PON1), an enzyme on HDL prevents oxidation of LDL thereby preventing the development of atherosclerosis. Studies done so far have lead to conflicting results. As studies are lacking in North-West Indian Punjabi’s, a distinct ethnic group with high incidence of coronary artery disease, we determined PONase activity in this population. It has been postulated that sudden lowering of serum PONase may lead to precipitation of acute myocardial infarction. We determined serum PONase activity and lipids in 100 patients each of AMI (within 24 h of onset), stable CAD and 100 age and sex matched healthy controls. These were again determined after 6 weeks in AMI patients. The mean serum PONase activity was lowest in AMI patients (23.26 U/ml) followed by stable CAD patients (102.0 U/ml) where as in controls was highest (179.8 U/ml). In patients with AMI, activity was significantly higher at 6 weeks as compared to that after acute event (49.39 %; p < 0.05). Sudden lowering of serum PONase activity in a population which already has lower activity may be one of the risk factors for development of AMI.  相似文献   

不同负荷训练对大鼠心肌细胞热休克蛋白70表达的影响     

陈艳  任建生 《通化师范学院学报》2009,30(2):58-60

通过建立大鼠有氧游泳训练和过度游泳训练运动心脏模型,观察长期不同负荷训练后心肌细胞HSP70的表达情况,探讨运动诱导心肌细胞HSP70表达的规律,旨在为进一步研究运动员心脏提供实验依据．研究结果表明,运动训练可诱导心肌细胞HSP70表达增强,并且HSP70的表达与运动负荷存在一定的关系,随运动负荷增加,其表达呈上升趋势．  相似文献   

超速驱动诱发大鼠离体心脏心肌顿抑的研究   总被引：3，自引：0，他引：3  

李新建  张钢林  邢少东  苏全生  赵广高 《成都体育学院学报》2010,36(4)

目的:通过电超速驱动模拟运动负荷诱发心肌顿抑现象,建立离体大鼠心脏运动性心肌顿抑模型.方法:将36只SPF级成年雄性SD大鼠随机分6组,用电刺激模拟运动负荷的方法来对大鼠离体心脏施加超速驱动,并根据驱动时间的不同进行分组,再分别测量记录各组驱动前后各指标的变化情况加以分析.结果:(1)各组左心室收缩压、发展压在驱动全过程呈下降趋势,舒张压呈上升趋势,而驱动前组间室内压无明显差异.(2)各组冠状动脉流出液CK、LDH在驱动前无明显差异,驱动后各实验组水平均高于对照组.(3)驱动20min组和30min组的心肌坏死率明显高于其他组,而其他组两两比较无组间差异.结论:(1)运动性心肌顿抑存在.(2)过长的高心率负荷将不再发生心肌顿抑现象而出现大面积心肌坏死.(3)本实验中,运动性心肌顿抑存在于5min组和10min组中.  相似文献   

耐力训练性与病理性心脏肥大对心肌超微结构影响的比较研究     

蔡秋  王翔  王步标 《广州体育学院学报》2001,21(2):28-31

为了解耐力运动性与病理性心脏肥大在形态学上的差异，本在大鼠游泳训练心肌肥大和肾血管性高血压肥大模型上，测量了各组心肌细胞参数及心肌线粒体比表面与内膜比膜面。结果表明：病理性心脏为向心性肥大，属于生理代偿反应，出现心肌舒张不全、收缩力下降的现象；长期负重训练对心肌功能的影响具有双重性，一方面通过肌纤维增粗，增强心肌收缩力，另一方面，心肌线粒体体密度、比表面不能随运动出现增加，且内膜的比膜面降低。可能是长期负重训练引起心肌舒张功能降低的形态学基础。  相似文献   

川芎嗪对麻醉家兔缺血再灌注心肌的保护作用     

汤碧娥  陈晓明  张宁 《金华职业技术学院学报》2007,7(4):63-65

目的:观察川芎嗪对家兔心肌缺血再灌注损伤的保护作用.方法:采用在体家兔冠状动脉阻断的缺血/复灌损伤模型,测定心肌梗死面积、血浆中乳酸脱氢酶(LDH)、肌酸激酶(CK)及天门冬酸氨基转移酶(AST)活性及各项心室力学指标.结果:与单纯缺血/复灌组相比,川芎嗪明显降低心脏缺血/复灌后的梗死面积和血浆中LDH、CK及AST含量,促进左室收缩压(LVSP)、最大左室收缩速率( dP/dtmax)和最大左室舒张速率(-dP/dtmax)的恢复.结论:川芎嗪预处理对家兔心肌缺血再灌注损伤有良好的保护作用.  相似文献