排序方式： 共有33条查询结果，搜索用时 15 毫秒
31.
Chuan Shao Jing-bo Jiang Hong-cheng Wu Shi-bo Wu Bi-yun Yu Yao-dong Tang 《Journal of Zhejiang University. Science. B》2015,16(3):215-223
Background and objectives: While an increasing number of people who snore are seeking medical consultations, the clinical characteristics of snorers are rarely reported. The aim of this study is to characterize the clinical and polysomnographic features in a population of snorers. Methods: A total of 490 subjects were examined retrospectively. The clinical history, Epworth Sleepiness Scale (ESS) scores, physical examination, and full-night polysomnography (PSG) data were obtained for all the subjects. The correlations between the neck circumference, waist circumference, ESS scores, body mass index (BMI), and apnea-hypopnea index (AHI) of obstructive sleep apnea (OSA) patients were explored. The gender and age differences in OSA patients were analyzed. Results: OSA was diagnosed in 84.7% of the sample, with 21.2% of the patients having a mild form, 15.4% having a moderate form, and 63.4% having a severe form of OSA. The ESS scores, neck circumference, waist circumference, and BMI were positively correlated with AHI in OSA patients. The ESS scores and BMI were negatively correlated with nadir oxygen saturation (SaO2). A greater number of men than women exhibited moderate to severe forms of the disease. OSA affects the work of males more commonly compared with females. Nocturia was a more common complaint in elderly OSA patients. Heart diseases coexisted more frequently with OSA in elderly patients. Conclusions: In a population of snorers, OSA is the most common condition identified. The ESS scores and BMI were well correlated with the severity of the disease. Men had a more severe form of OSA than women. Nocturia frequently occurred in elderly OSA patients, as did the coexistence of heart disease. 相似文献
32.
目的：探讨低氧和运动训练对大鼠学习记忆的作用和交互作用及其与突触可塑性之间的关系。方法：采用交互设计的研究方案对SD大鼠进行8周的14．2％的低氧暴露或／和60 min的无负重游泳训练后,通过 Morris水迷宫检测大鼠的学习和记忆能力,观察大鼠海马的超微结构,并检测海马神经生长相关蛋白‐43（GAP‐43）、突触素（SYP ）和神经细胞粘附因子（NCAM ）mRNA的表达量。结果：1）长期的低氧暴露可使大鼠的潜伏期显著增加（ P＜0．05）,穿越平台的次数显著减少（P＜0．05）,运动训练能使大鼠的潜伏期显著缩短（P＜0．05）,穿越平台的次数显著增加（ P＜0．05）,低氧联合运动训练对缩短大鼠潜伏期、提高大鼠穿越平台次数没有显著的交互作用（ P＞0．05）。2）与 NC组比较,HC组海马突触数量和突触小泡少,突触间隙模糊不清。与NE组相比,HE组海马内突触数量以及突触小泡数量有所减少,突触后膜致密物质（PSD ）厚度减小。3）长期低氧暴露可使大鼠海马区 GAP‐43、NCAM mRNA表达显著降低（P＜0．05）,SYP mRNA表达下降,但无显著性差异（P＞0．05）,运动训练可使大鼠海马GAP‐43、SYP、NCAM mRNA表达显著增加（ P＜0．05,P＜0．01）,在低氧条件下进行运动训练对提高GAP‐43、SYP、NCAM mRNA表达没有显著的交互作用（ P＞0．05）。结论：1）长期的低氧暴露可抑制学习记忆能力,而运动训练能够增强学习记忆能力,虽然运动训练在一定程度上可以改善低氧暴露大鼠的学习记忆能力,但是并不能完全逆转低氧暴露所造成的学习能力下降。2）长期的低氧暴露或运动训练通过下调或上调海马GAP‐43、SYP和NCAM mRNA的表达,抑制或增强海马突触结构的可塑性,可能是影响学习记忆能力的重要机制。 相似文献
33.
高原和低氧训练被认为对于运动员机能状况和运动能力的提高有一定的效果,已有研究表明[1],低氧暴露和高原训练可对免疫功能产生抑制作用.实验以雄性SD大鼠为实验对象,以符合跑台训练方式建立低氧训练模型.实验结果表明:服用贞芪扶正胶囊的大鼠体重及脾重含量明显高于其对照组(P0.05),说明服用贞芪扶正胶囊可以使血液中淋巴蛋白增高,阻止了机体防止免疫球蛋白分解,从而使防御性抗体形成. 相似文献