首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   296篇
  免费   0篇
  国内免费   3篇
教育   241篇
科学研究   23篇
各国文化   1篇
体育   8篇
综合类   9篇
信息传播   17篇
  2021年   6篇
  2020年   4篇
  2019年   6篇
  2018年   1篇
  2017年   2篇
  2016年   5篇
  2015年   4篇
  2014年   15篇
  2013年   22篇
  2012年   19篇
  2011年   26篇
  2010年   36篇
  2009年   35篇
  2008年   33篇
  2007年   18篇
  2006年   14篇
  2005年   17篇
  2004年   8篇
  2003年   8篇
  2002年   5篇
  2001年   5篇
  2000年   3篇
  1999年   2篇
  1997年   1篇
  1996年   1篇
  1995年   1篇
  1989年   1篇
  1982年   1篇
排序方式: 共有299条查询结果,搜索用时 46 毫秒
21.
弱势群体权利保护是当前倍受关注的社会问题。于建星博士克服情感冲动,冷静理性思考,立足自由及其自由的实现视角,就弱势群体权利保护问题,提出了一系列令人注目的观点,凝著而为《弱势群体权利保护研究》,这又为当前社会公平正义研究,特别是弱势群体权利保护开辟一个新的理论空间和实践思路。  相似文献   
22.
关于高校文秘专业《现代汉语》教学的一点思考   总被引:2,自引:0,他引:2  
文秘专业的现代汉语教学要以提高学生的语言文字素养为目标,不断调整教学内容,转变教学思路,突出课程的实用性,增强课程的实践性、趣味性和人文性,结合专业实际,丰富教学方法。  相似文献   
23.
Objective: To assess if arachnoid cells have the capability to present antigen and activate T-lymphocytes after stimulation by bloody cerebrospinal fluid (CSF), and to illuminate the mechanism of coagulation-initiated inflammation in the subarachnoid space after subarachnoid hemorrhage (SAH). Methods: Arachnoid cells were cultured, characterized, and examined by immunofluorescence for the basal expression of human leukocyte antigen-DR (HLA-DR). Expression of HLA-DR, after co-culturing arachnoid cells in vitro with bloody CSF, was investigated by immunofluorescence and flow cytometry (FCM). The variation of arachnoid cells' ultrastructure was observed by transmission electron microscope (TEM). Arachnoid cells were co-cultured with peripheral blood mononuclear cells (PBMCs). The content of soluble interleukin-2 receptor (sIL-2r) in culture medium was detected by enzyme-linked immunosorbent assay (ELISA). Results: (1) Arachnoid cells were successfully cultured for many passages. The immunofluorescent staining was positive for HLA-DR in over 95% of the human arachnoid cells. The punctate HLA-DR was distributed in cytoplasm and not in the karyon. (2) After co-culturing arachnoid cells in vitro with bloody CSF, numerous particles with strong fluorescence appeared in the cytoplasm on Day 6. On Day 8, the quantity of particles and fluorescent intensity were maximal. FCM showed that the percentage of HLA-DR expressing cells was (2.5±0.4)% at the first 5 d, increasing to (60.8±3.6)% on Day 7. (3) After co-culturing arachnoid cells in vitro with bloody CSF, many lysosome and secondary lysosome particles were present in the cytoplasm. Hyperplasia of rough endoplasmic reticulum and enlarged cysts were observed, with numerous phagocytizing vesicles also observed at the edge of the arachnoid cells. (4) Arachnoid cells stimulated by bloody CSF were co-cultured in vitro with PBMCs. The content of sIL-2r in the culture medium, having been maintained at around 1.30 ng/ml during the first 3 d, had increased by Day 4. The content of sIL-2r peaked 7.53 ng/ml on Day 7 and then reduced gradually. Conclusions: (1) Basic HLA-DR expression is present in arachnoid cells. (2) After stimulation by bloody CSF, arachnoid cells have the potential to serve as antigen presenting cells (APCs) and the ability to activate T-lymphocytes, indicating that arachnoid cells are involved in the mechanism of coagulation-initiated inflammation in the subarachnoid space after SAH.  相似文献   
24.
25.
中国古代小说中的狐意象,源于远古时期先民的图腾崇拜意识。两汉时期,它呈现出瑞兽和妖兽的双重身分。从六朝到唐代,狐在被神化和妖化的同时,也不断地在向人的方向发展,逐渐获得人的外形和气质。到了明清时期,文学作品中狐的形象和内涵更加丰富多彩,其反映社会生活的广度和深度也达到前所未有的程度。尤其《聊斋志异》中具有人形美、人性美、人情美的狐意象,既是作者寄托情感、慰藉心灵、超越现实、实现生命价值的载体,更是那个时代社会、文化状况的反映。  相似文献   
26.
远程开放教育就是以学生为中心的全方位的助学服务;远程开放教育的教的过程就是为学生提供全方位学习支持服务的过程,而学的过程就是学生使用、接受服务的过程,做好学习支持服务是确保开放教育顺利进行的保证。本文主要从《计算机应用基础》课程的导学过程来说明是如何为开放教育学员提供完善的支持服务的。  相似文献   
27.
细胞生物学教学改革与实践   总被引:1,自引:0,他引:1  
对细胞生物学课程的教学内容、教学方法和手段、课程考核方法等进行了合理的调整和优化改革,以适应新形式下素质教育的需要,全面提高教学质量,努力培养高素质的专业人才.  相似文献   
28.
目的:在康脑液方剂干预下观察皮质区内源性神经细胞干细胞因子(SCF)mRNA在大鼠脑缺血再灌注损伤后不同时间的表达情况。方法:成年SD大鼠,以线栓法建立大脑中动脉缺血再灌注模型,随机分为模型组、药物干预组和假手术组。原位杂交技术检测脑缺血1.5h再灌注1~14d后,脑皮质区SCFmRNA表达情况。结果:脑缺血再灌注后,药物干预组、模型组SCFmRNA的表达在皮质区均明显高于假手术组,于第7天达高峰,第14天下降。结论:药物干预后脑缺血再灌注脑皮质区SCFmRNA表达在不同时间点与模型组具备相同的表达规律,两组SCFmRNA的表达无显著性差异。  相似文献   
29.
开明书店青年读物出版特色探析   总被引:1,自引:0,他引:1  
论文以《中学生》杂志为个案,从《中学生》杂志的出版宗旨及开明书店的出版成果、目标市场的选择等方面分析其青年读物的出版特色。  相似文献   
30.
The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group, is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号