Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Analyzing Food Science Research for Publishing Characteristics as a Model for Understanding the Needs of Researchers     

Lutishoor Salisbury  Jeremy J. Smith  Abayomi Omotola Omolewu 《资料收集管理》2020,45(4):335-353

Abstract

This paper provides a methodology to study the characteristics of the research output from a university department. The faculty publications and their cited references over a 10-year period were used as the basis for this study to identify their publishing patterns and the types of material they are publishing; a core set of journals and other resources they are publishing in and citing over this period; the characteristics of the journals in which they publish and cite; the degree of openness of their publications and their citation advantage; and the age of resources that are referenced.  相似文献   

杭州市老年人体育锻炼的特点和现状的调查研究   总被引：2，自引：0，他引：2  

何晓芸  于可红 《浙江体育科学》2003,25(6):11-13

通过献资料法、问卷调查法和数理统计法，对目前杭州市老年人的生活特点、体育锻炼的目的、内容方式和影响制约老年人进行锻炼的因素进行分析，总结杭州市老年人参与体育锻炼的特点和现状。并通过分析，提出更加合理与科学的锻炼方法，从而能使老年人的锻炼更加有意义，使老年的生命更有质量。  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

高校体育教学改革研究   总被引：7，自引：1，他引：6  

陈桂平 《安徽体育科技》2003,24(3):82-83,101

根据教育部下发的《全国普通高等学校体育课程教学指导纲要》，从当前国内外体育教学现状、未来高校体育教学发展趋势以及体育教学改革中的矛盾等方面进行了分析研究。  相似文献   

谈谈高校外文图书采访改革   总被引：15，自引：0，他引：15  

韩冬丽 《江西图书馆学刊》2003,33(2):21-22

外图书采访一直是高校图书馆献资源建设的重点之一，结合本馆外图书采访的实际工作经验，提出改革外图书采购模式的若干看法。  相似文献   

GM(1,h)系统状态模型在田径训练中的应用   总被引：4，自引：0，他引：4  

刘嘉津  孙桂云 《上海体育学院学报》2003,27(1):78-81,F003

将多因素整体状态GM（1，h)模型及其特列GM（1，1）模型结合起来，用于高水平田径训练的建模问题研究，使建立的系统模型既能反映系统内部多因素的整体关系，又能满足超前预测和规划的需要，旨为田径训练提供了一种有效的科学方法。  相似文献   

电大生《经济数学基础》课程学习困难的成因分析   总被引：1，自引：0，他引：1  

潘红卫 《广西广播电视大学学报》2003,14(4)

本文对电大生《经济数学基础》课程学习困难的成因进行了分析,并对教师在该课程教学中要注意的问题提出了几点建议。  相似文献   

甘肃省中小学青年体育教师综合素质的调查研究     

王建民  谢芳  张永贵  盛建国  丁斌  唐广旭 《北京体育大学学报》2006,29(8):1105-1107

运用问卷调查法、数理统计法等对我省225名中小学青年体育教师的师德修养、文化素质、心理素质、科研能力和社会适应能力等方面进行了调查,对调查结果进行了分析讨论并提出了相应对策,为高师体育教育本科专业教育教学改革提供了依据和参考.  相似文献