中老年脂肪肝与高脂血症、糖尿病、高尿酸血症、高血压的相关性研究     

颜庆华 《湖州师范学院学报》2005,27(1):116-118

对2003年9月湖州师范学院教职工体检的471位中老年教职工的脂肪肝与高脂血症、高血糖、高尿酸血症、高血压疾病的相关性进行分析研究．经统计学检验，发现脂肪肝组患高脂血症、高血糖、高尿酸血症、高血压疾病的患病率与非脂肪肝组的患病率比较有显著差异．分析认为：脂肪肝是由各种原因引起的肝脂肪蓄积过多的一种病理状态，脂肪肝与其并存的相关疾病虽然发病机制不同，但均属于生活习惯病，常合并存在，互相影响，且互为因果，彼此相关，严重地危害着中老年人的健康和生命，应当加强宣传和积极防治．  相似文献   

中老年高血压病临床特点的对比观察     

彭日轩 《衡阳师范学院学报》1993,(6)

本文对45例中老年人高血压病的临床观察,结果表明:老年病人平均收缩压、脉压差均明显高于中青年人;且左心室受累,血脂增高,心脑、肾动脉硬化,合并症多,死亡率高。  相似文献   

洛丁新对老年高血压性肾损害的干预作用     

李春秀 《襄樊职业技术学院学报》2004,3(6):33-34

目的观察洛丁新对老年高血压性肾损害患者肾功能的影响。方法将100例老年高血压病伴有肾损害的病人用洛丁新治疗四周,比较用药前后肾功能的变化。结果老年高血压病伴有轻、中度肾损害的患者治疗后较治疗前BUN和Scr有显著减少(P<0.05),Ccr较前有极显著的增高(P<0.01);伴有重度肾损害的老年高血压病患者治疗后BUN和Scr也较前有所减少,Ccr较前亦增高,但此变化无统计学意义(P>0.05)。结论洛丁新能明显的改善老年高血压病伴有轻、中度肾损害患者的肾功能。  相似文献   

VEGFmRNA and eNOSmRNA expression in immature rabbits with bleomycin-induced pulmonary hypertension     

龚方戚  林幼敏  汤宏峰  顾伟忠  汪伟  康曼丽 《浙江大学学报(A卷英文版)》2004,5(8):995-1000

Objective: To investigate the evolution of pulmonary hypertension, the pathological changes of pulmonaryarteries, and the expression of VEGFmRNA and eNOSmRNA of pulmonary arterial endothelial cells in immature rabbitstreated with intratracheal bleomycin (BLM). Methods: Immature rabbits were divided into control and BLM group. Twoand four weeks after intratracheal normal saline or BLM injection, the systolic, diastolic and mean pulmonary arterypressure (PASP, PADP, MPAP) were measured by micro-catheter; the pathological changes and the expression ofVEGFmRNA and eNOSmRNA of endothelial cells in pulmonary arteries were evaluated by HE and in situ hybridization.Results: Two and four weeks after intratracheal injection of BLM, the PASP, PADP and MPAP increased 53%, 49%, 52%in 2 weeks, and 43%, 89%, 56% in 4 weeks; the wall thickness increased and the cavity in middle and small pulmonaryarteries became narrow; the Thickness Index (TI) and Area Index (AI) increased 25%, 14% in 2 weeks, and 22%, 24% in 4weeks; the level of VEGFmRNA and eNOSmRNA expression decreased 46%, 43% in 2 weeks, and 43%, 51% in 4 weeks.There was no significant difference between 2 weeks and 4 weeks BLM groups. Conclusion: The pulmonary artery pressurewas elevated, the thickness of wall increased and the cavity became narrow in middle and small pulmonary arteries, and thelevel of VEGFmRNA and eNOSmRNA expression in pulmonary arterial endothelial cells decreased in immature rabbitsafter 2 weeks and 4 weeks of intratracheal 4 U/kg BLM injection.  相似文献   

门脉高压征门奇静脉断流术后胃破裂的防治     

屈明  薛军  杨东东 《河北北方学院学报(医学版)》2005,22(3):30-31

目的:探讨门奇静脉断流术后胃破裂的原因和防治措施.方法:回顾分析1995.1～2003.2月我院65例门脉高压征行门奇静脉断流术 脾切除术后胃破裂的患者.结果:65例患者中2例患者术后发生胃底破裂,1例经二次开腹修补破裂口痊愈,后因肝功能衰竭死亡,另一例二次术后痊愈出院,随访至今无严重并发症出现.结论:门奇静脉断流术 脾切除术中离断脾胃韧带时尽量靠脾侧切断韧带,近胃侧断端贯穿缝扎并包埋于浆膜腔内,术后持续胃肠减压,同时给予止酸保护胃粘膜药物治疗,可有效防止该并发症的发生.  相似文献   

Science Letters: Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension     

YU Min  WANG Xing-xiang  ZHANG Fu-rong  SHANG Yun-peng  DU Yu-xi  CHEN Hong-juan  CHEN Jun-zhu 《Journal of Zhejiang University. Science. B》2007,8(4)

Idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.  相似文献   

高血压合并高尿酸血症患者的治疗药物选择     

张松波  段娟 《岳阳职业技术学院学报》2011,26(3):80-82

目的比较氯沙坦与氨氯地平治疗老年高血压合并痛风患者的疗效。方法将2009年5月至2010年3月期间收治的高血压合并痛风患者64例,随机分为两组,一组口服氯沙坦50mg/d,另一组给予氨氯地平5mg/d,治疗6周。观察患者服药后舒张压(DBP)、收缩压(SBP)、血清尿酸等指标的变化。结果治疗6周后,氯沙坦与氨氯地平都能有效降压和降低血尿酸水平(P相似文献   

老年高血压病左室肥厚与神经体液因素及室性早搏的相关性   总被引：1，自引：0，他引：1  

郭航远  鲁端  王建安  何红  张湘兰  周斌全  蒋晨阳 《科技通报》2001,17(1):63-66

为探讨老年高血压病左室肥厚（LVH）与部分神经体液因素之间的关系及与室性早搏，心肌缺血的相关性，老年高血压病伴左室肥厚60例为A组，单纯老年高;血压病60例为B组，对比观察心率变异，肾素（Ren)，血管紧张素（AT－II），醛固酮（Ald)，胰岛素峰值（Ins),24h动态心电图和血压等指标，结果显示：1）A组病人交感神经张力明显增高，迷走神经活性下降不明显，室性早搏的发生与交感神经张力增高有关；室性早搏与心肌缺血具有相关性；2）A组病人与Ald及Ins水平有关，与Ren和AT－II无明显相关；3）A组病人与室性早搏和心肌缺血明显相关，结论表明，老年高血压病在室肥厚患者交感神经张力增高，Ald及Ins水平升高，与室性早搏，心肌缺血具有正相关。  相似文献   

VEGFmRNA and eNOSmRNA expression in immature rabbits with bleomycin-induced pulmonary hypertension     

龚方戚  林幼敏  汤宏峰  顾伟忠  汪伟  康曼丽 《Journal of Zhejiang University. Science. B》2004,(8)

INTRODUCTION Pulmonary hypertension is not rare in humanwith some heart and lung diseases. Chronic pul-monary hypertension leads to structural alterationsof the lung vessels. The pathophysiology of thisremodeling process is still poorly understood.Furthermore, the structural damage of the lungvessels limits the clinical success of vasodilatortreatment. Assuming genetic susceptibility, shearstress and inflammation are the principal pathoge-netic factors involved in lung vessel remode…  相似文献   

Uric acid as one of the important factors in multifactorial disorders--facts and controversies     

Pasalic D  Marinkovic N  Feher-Turkovic L 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):63-75

With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.  相似文献