排序方式： 共有41条查询结果，搜索用时 31 毫秒
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美国博德研究所自2004年成立起,坚持科技创新与管理创新并重;不到10年,即迈入世界一流生命科学研究机构行列,成为生命科学前沿创新的“领头羊”“风向标”,其独特的发展模式值得借鉴。研究表明,聚焦重大疾病诊治需求牵引科研攻关,打通从基础研究到转化应用的通路,构建跨学科、多层次整合研究模式,发挥战略科学家的领航领军作用,集聚小而精的杰出科学家团队,实施高度灵活的项目组织管理,以及打造背靠一流、辐射全美、拓展全球的创新网络,有效支撑了博德研究所高质量创新发展。我国可借鉴其经验,从将生命科学作为建设科技强国的突破口、面向人民生命健康加强顶层设计、夯实生命科学人力资源根基、深度融入生命科学全球创新网络4个方面,推进生命科学前沿创新。 相似文献
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药剂学是以多学科理论为基础的综合性应用技术科学,是药学研究中不可或缺的重要一环,这对药剂学专业研究生培养提出了更高的要求。针对现有本专业研究生教育现状,文章提出以下改进方案:(1)改变传统教学模式,培养研究生主动思考能力,及时追踪研究前沿;(2)突出军事特色,致力于将药剂学最新研究成果应用到军事药剂学中;(3)减少集中授课时间,鼓励研究生尽早进入科研一线;(4)改变应试教育下研究生的固有思维模式,鼓励源头性创新;(5)亦师亦友,因材施教;(6)全方位培养,提升综合能力。研究生导师责任重大,要明确研究生培养目标,为国家科技发展培养更多高层次人才。 相似文献
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Ying Wang Guoxing You Peipei Chen Jianjun Li Gan Chen Bo Wang Penglong Li Dong Han Hong Zhou Lian Zhao 《Biomicrofluidics》2016,10(2)
The mechanical properties of red blood cells (RBCs) are critical to the rheological and hemodynamic behavior of blood. Although measurements of the mechanical properties of RBCs have been studied for many years, the existing methods, such as ektacytometry, micropipette aspiration, and microfluidic approaches, still have limitations. Mechanical changes to RBCs during storage play an important role in transfusions, and so need to be evaluated pre-transfusion, which demands a convenient and rapid detection method. We present a microfluidic approach that focuses on the mechanical properties of single cell under physiological shear flow and does not require any high-end equipment, like a high-speed camera. Using this method, the images of stretched RBCs under physical shear can be obtained. The subsequent analysis, combined with mathematic models, gives the deformability distribution, the morphology distribution, the normalized curvature, and the Young''s modulus (E) of the stored RBCs. The deformability index and the morphology distribution show that the deformability of RBCs decreases significantly with storage time. The normalized curvature, which is defined as the curvature of the cell tail during stretching in flow, suggests that the surface charge of the stored RBCs decreases significantly. According to the mathematic model, which derives from the relation between shear stress and the adherent cells'' extension ratio, the Young''s moduli of the stored RBCs are also calculated and show significant increase with storage. Therefore, the present method is capable of representing the mechanical properties and can distinguish the mechanical changes of the RBCs during storage. The advantages of this method are the small sample needed, high-throughput, and easy-use, which make it promising for the quality monitoring of RBCs. 相似文献
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目的从昆明鼠睾丸中克隆Bmi1基因,构建真核表达载体,并转染支持细胞,以便用作培养精原干细胞（SSCs）的滋养层.方法以5日龄昆明鼠为材料,提取小鼠睾丸组织中总RNA后,以RT-PCR技术克隆小鼠睾丸Bmi1基因,构建真核表达载体,并转染TM4细胞（睾丸支持细胞株）,在转染后40 h进行免疫荧光鉴定.结果成功克隆小鼠睾丸Bmi1基因的cDNA,测序正确;免疫荧光细胞染色显示,转染后的支持细胞中有Bmi1蛋白表达.结论本研究为以转染了Bmi1基因的支持细胞作饲养层培养SSCs奠定了基础. 相似文献
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Dynamic response of RPC-filled steel tubular columns with high load carrying capacity under axial impact loading 总被引：3，自引：0，他引：3
Experimental investigation into impact-resistant behavior of reactive powder concrete (RPC)-filled steel tubular columns was conducted,and dynamic response of the columns under axial impact loading was studied by means of numerical simulation method.Increase coefficient of load carrying capacity and ratio of load carrying capacity between steel tube and RPC core of col-umns were obtained. 相似文献
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基础医学研究论文"讨论"部分的编辑加工 总被引：4，自引：0，他引：4
基础医学研究论文中一般都有“讨论”部分。由于作者对此部分的重视程度不够，加上专业知识的限制，“讨论”成为论文最薄弱的部分。编辑更应重视对讨论部分的编辑加工。 相似文献
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充分发挥编委作用增强学术刊物竞争力 总被引：8，自引：2，他引：6
编委会是学术性期刊不可缺少的组成部分.编委既是各学科领域的科研带头人,也是刊物水平的代表.使身兼数职的编委在繁忙的科研与事务性工作中关心刊物的近况与发展、热心编委工作,是刊物提高竞争力,在竞争中取胜的重要途径之一. 相似文献
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杨兆弘 《中华医学图书馆杂志》2014,(3):62-65
目前,我国学术论文出现明显向SCI等数据库收录期刊及核心期刊的现象。本文探究了这种流向的原因,指出发表论文的客观要求、科研人员的自利性因素、科研评价的导向与推动、科研人员的投稿偏好性等是影响学术论文发表的重要因素,并提出有效完善科研评价制度、客观分析科研人员自利性因素,制定学术道德的相应规范、提高期刊质量和完善学术出版规范是吸引高质量论文的措施。 相似文献