瘦素及其临床意义   总被引：4，自引：0，他引：4  

黄学元  梁俊 《安徽教育学院学报》2005,23(3):94-97

瘦素是一种蛋白激素,对调节体重、新陈代谢、生育功能有重要影响,具有广泛的生物学意义.在临床上瘦素浓度还被发现和肥胖症、心血管疾病、Ⅱ型糖尿病、不育症、骨质疏松、肾脏病、骨关节炎、脂肪肝和乳腺癌等许多疾病有关联.  相似文献   

基于深度学习网络的乳腺癌图片分类研究     

程年  俞晨  宁静艳 《教育技术导刊》2019,18(8):26-28

利用深度学习网络对组织病理图片进行分类,以减少病理学家工作量,达到利用计算机辅助治疗的效果。提出利用在两种预训练好的框架下提取的特征进行训练,并研究了多级分类,该成果有利于癌症后期治疗,更加方便临床医学应用;利用迁移学习能够减少训练时间,并解决数据集不足的问题;通过数据增强的方法,可有效提高分类准确度。  相似文献   

多媒体教学融入乳腺外科诊治教学中适用探究     

任光辉  郝晓妍  马斌林 《南昌教育学院学报》2013,(10):53-54

乳腺外科是一门专业性和社会实践性很强的学科,并且对学生医学知识有很高要求。以往学生在传统乳腺外科学习中因为学科枯燥无味而提不起兴趣,而在乳腺外科诊治教学中融入多媒体可将枯燥的医学知识转化为形象生动的动画和音乐,从而提高学生的学习兴趣。本文主要对多媒体在乳腺外科诊治教学中进行探究。  相似文献   

Uncertainty and previvors’ cancer risk management: understanding the decision-making process     

Marleah Dean  Carla L. Fisher 《Journal of Applied Communication Research》2013,41(4):460-483

Women who test positive for a BRCA genetic mutation, but who have not been diagnosed, or 'previvors,' experience intense, chronological risk-related uncertainty. Women’s risk management medical decisions can be a way to manage their uncertainty, but little is known about how uncertainty informs their decision or how uncertainty is impacted by these medical decisions. Using an uncertainty management theoretical lens, we interviewed 46 previvors about their decision-making process. A thematic analysis revealed two uncertainty management (i.e., risk-reducing) decision-making pathways (preventive surgery and increased surveillance) with each pathway encompassing a three-part process of 1) uncertainty appraisal, 2) medical decision (i.e., uncertainty management strategy), and 3) outcomes. The findings advance theoretical thinking about uncertainty and risk management as an ongoing, distressful chronic experience, and highlight the importance of life-span phenomena in women’s decision-making process. Based on the findings, we constructed a translational tool to aid genetic counselors and previvors facing these medical decisions.  相似文献   

Intensity of lifetime physical activity and breast cancer risk among Polish women     

Joanna Kruk 《Journal of sports sciences》2013,31(5):437-445

Abstract

Physical activity is associated with a lower risk of breast cancer, although research findings are inconsistent regarding the type, duration, intensity, and frequency of activities that are necessary to reduce the risk, as well as dependence on menopausal status. To address these issues, I examined the effect of physical activity on breast cancer risk among 858 Polish invasive breast cancer cases and 1085 controls. Data on components of lifetime household, occupational, and recreational activities were collected in 2003–2007, using a self-administered questionnaire. Odds ratios with 95% confidence intervals were estimated using unconditional logistic regression analyses and a full assessment of confounding variables. For all types of physical activity, odds ratios were calculated for self-reported and compendium-based assigned levels of activity. Moderate- and vigorous-intensity total and recreational activities, as well as moderate- and long-lasting low-intensity household activities, lowered the risk by at least 44% for the highest versus lowest quartiles of activity in both menopausal groups. The associations were linear (P_trend≤ 0.009). There was a suggestion of a risk reduction for occupational activity among post-menopausal women. These findings show that a risk reduction can be achieved by vigorous-intensity activities or by longer-lasting activities of moderate-intensity.  相似文献   

乳癌细胞核DNA含量与预后     

雷杰  张振忠  李德仪 《河北北方学院学报(医学版)》1999,(3)

本文应用流式细胞术(Flow Cytometry,FCM)检测了102例石蜡包埋的乳癌组织的细胞核DNA含量,并探讨了DNA指数(DNA Index.DI)和S期细胞比例(S-phase Fraction,SPF)与临床预后因素及病人术后生存状况的关系。结果显示:16例为DNA二倍体,8例近二倍体,78例(77％)非整倍体。非整倍体癌较二倍体/近二倍体癌的SPF高。DI值与组织学分级、淋巴结状况、原发肿瘤大小和临床分期密切相关,而与病人诊断时的年龄无关。淋巴结转移阳性组较阴性组、晚期肿瘤(Ⅲ、Ⅳ期)比早期肿瘤(Ⅰ、Ⅱ期)的DI值高(P<0.05),而非整倍体率仅有降低的趋势但无显著性差异,说明DI值作为一个预后参数比倍性分析统计效率高。SPF与病人的各预后因素及生存情况无明显关系。二倍体/近二倍体癌病人较非整倍体癌病人的生存率高、无瘤生存时间长,说明流式细胞术DNA含量测定确实可为乳癌病人的预后提供有价值的信息。  相似文献   

基质金属蛋白酶-2在乳腺癌中的表达及与侵袭、转移的关系     

任欣  陈英杰  陶雅军  刘健 《大连大学学报》2002,23(6):99-101

[目的]探讨乳腺癌细胞基质金属蛋白酶-2的表达及其与侵袭、转移的关系.[方法]免疫组织化学方法检测60例乳腺癌患者癌组织中MMP-2表达.[结果]MMP-2的表达在乳腺癌细胞明显高于正常乳腺细胞(P<0.01);淋巴结转移组明显高于非淋巴结转移组(P<0.01);在中、低分化组明显高于高分化组(P.<0.01).但与组织学类型无关(P<0.05).[结果]乳腺癌的MMP-2的表达与其侵袭、转移可能相关.  相似文献   

BRCA1/2 associated hereditary breast cancer     

Li-song TENG  Yi ZHENG  Hao-hao WANG 《Journal of Zhejiang University. Science. B》2008,9(2)

Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes,focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial;further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.  相似文献   

微波近场成像法在乳腺癌检测中的应用     

肖李敏  黄江波 《涪陵师范学院学报》2004,20(5):64-66

介绍了乳腺癌微波近场成像方法的优越性及原理，给出了早期乳腺癌微波检测中的时域波束形成模型和嵌入式波束形成器的模块结构。  相似文献   

基于PLAXIS的深基坑支护的有限元分析     

王宏 《嘉应学院学报》2014,(5):74-77

深基坑开挖支护作为岩土工程的一项基本课题,一直以来是研究的热点和难点.以重庆市沙坪坝区某一工程为研究对象,通过有限元分析软件PLAXIS对深基坑的开挖、支护全过程进行模拟分析,研究支护结构的内力变形情况.发现其水平位移、竖向位移均满足设计要求;发现支护结构弯矩剪应力均发生在其中部位置.  相似文献