肺动脉高压发病机制及有氧运动干预对其改善的分子机制研究进展     

滑艺杰  王友华 《中国体育科技》2020,(5):71-79

肺动脉高压(pulmonary arterial hypertension,PAH)是一类以肺动脉渐进性闭塞导致肺血管阻力逐渐升高继而诱发右心室衰竭的一种恶性肺血管疾病。PAH病理发生、发展的机制包括炎症反应诱发的内质网应激(endoplasmic reticulum stress,ERS),继而促使血管平滑肌细胞过度增殖和迁移;以及线粒体自噬相关蛋白PINK1和Parkin以及LC3的表达增加,使血管平滑肌呈现抗凋亡表型,并伴随有氧氧化功能损伤,无氧酵解依赖性增加等问题。PAH进一步发展会诱发多种并发症,包括低氧血症、肺纤维化以及右心肥大,可直接引起肺动脉压增加,继而增加心脏压力导致心力衰竭,这是病理发展的主要方向。作为可能治疗PAH的手段之一,有氧运动可从调控ERS、线粒体自噬、改善机体代谢3个方面抑制PAH病理进程。研究综述了近年来关于PAH发生、发展的分子机制的研究进展,进一步论述了有氧运动对PAH改善的分子机制。  相似文献   

白俄罗斯皮划艇协会与国际皮划艇联合会体育仲裁案例评述          下载免费PDF全文

邵沁雨 《体育科研》2018,(1):17-25,34

通过对2016年白俄罗斯皮划艇协会与国际皮划艇联合会体育仲裁案例的分析，得出研究结论：禁用药物超长的代谢时间不能成为反兴奋剂规则具有溯及力的理由；虽然《世界反兴奋剂条例》第11条的规定因为存在"集体项目"这一前提而没有违反个人责任原则，但该条第12条由于规定得过于简单仍然违反了该原则；国家司法机关刑事诉讼程序中发现的兴奋剂药物证据，在刑事诉讼程序终止而证据未经质证的情况下，不能直接作为兴奋剂违规行为的认定证据。  相似文献   

What determines the duration of patent examination in China? An outcome-specific duration analysis of invention patent applications at SIPO     

Tony W. Tong  Kun Zhang  Zi-Lin He  Yuchen Zhang 《Research Policy》2018,47(3):583-591

Although China is now the largest patent filing country in the world, research on the duration and outcomes of patent examination remains scarce. In this study, we conduct a replication and extension of Harhoff and Wagner’s (2009) work on the determinants of patent examination duration at the European Patent Office (EPO), using a rich dataset covering the population of about 1.1 million invention patent applications to China’s State Intellectual Property Office (SIPO) from 1993 to 2006. By considering all three competing examination outcomes (grant, withdrawal, and refusal) simultaneously, our competing risks analysis replicates many of the results in prior research and confirms that a number of the determinants have differential effects on pendencies for different outcomes. Our analysis also reveals several applicant and application characteristics whose effects on pendencies for specific outcomes differ from prior research. Finally, by incorporating a number of new determinants, we report a set of new findings about their effects on the examination duration for the three outcomes at SIPO.  相似文献   

Effect of contact and no-contact small-sided games on elite handball players     

Antonio Dello Iacono  Domenico Martone  Alessandro Moura Zagatto  Yoav Meckel  Mahmood Sindiani  Mirjana Milic 《Journal of sports sciences》2018,36(1):14-22

This study aimed to investigate the effect of contact (C-SSG) and no-contact (NC-SSG) handball small-sided games (SSGs) on motion patterns and physiological responses of elite handball players. Twelve male handball players performed 10 C-SSG and 10 NC-SSG while being monitored through the heart rate (HR) and rate of perceived exertion (RPE) as physiological responses and time-motion activities profile using video-match analysis. Both game conditions resulted in similar HR responses (P > 0.05), but the NC-SSG led to a higher RPE scores. The time-motion activity analysis featured NC-SSG with a greater amount of walking (855.6 ± 25.1 vs. 690.6 ± 35.2 m) and backward movements (187.5 ± 12.3 vs. 142.5 ± 8.7 m) combined with fast running (232.3 ± 8.5 vs. 159.7 ± 5.7 m) and sprinting (79.5 ± 4.7 vs. 39.7 ± 3.7 m) activities (P < 0.001). Conversely, C-SSG had a higher percentage of jogging and sideway movements associated with greater frequency of jumping (0.87 ± 0.09 vs. 0.31 ± 0.06 nr) and physical contact (1.82 ± 0.55 vs. 0.25 ± 0.03 nr) events (P < 0.001). No between-regimen differences were found for the number of throws (P = 0.745). In addition, the RPE was significantly correlated with fast running relative distances (r = 0.909, P < 0.001) and sprinting relative distances (r = 0.939, P < 0.001). In conclusion, this investigation showed that both C-SSG and NC-SSG in team handball can effectively represent specifically oriented exercises, according to the sport-task and the performance demands.  相似文献   

江苏省高技术产业人才需求预测研究——基于改进的新陈代谢GM(1,1)模型     

胡峰  陆丽娜  黄斌  周文魁 《科技管理研究》2018,(16)

利用改进的新陈代谢GM(1,1)模型,借助MATLAB对江苏省高技术产业2016—2020年的人才总量进行灰色预测,并与通过模型预测出的广东、浙江省的高技术产业的人才总量进行对比。建模结果表明,改进的新陈代谢GM(1,1)模型的预测精度比常规模型提高了将近50%,也比新陈代谢GM(1,1)模型和背景值优化模型精度高。预测结果表明,"十三五"末江苏省高技术产业人才总量约为2 549 424人,位于广东之后;人才年均增速约为0.5%,位于浙江、广东之后。  相似文献   

Does self-perceived sleep reflect sleep estimated via activity monitors in professional rugby league athletes?     

Johnpaul Caia  Heidi R. Thornton  Vincent G. Kelly  Tannath J. Scott  Shona L. Halson  Balin Cupples 《Journal of sports sciences》2018,36(13):1492-1496

This study examined agreement between self-perceived sleep and sleep estimated via activity monitors in professional rugby league athletes. 63 athletes, from three separate teams wore actigraphy monitors for 10.3 ± 3.9 days. During the monitoring period, ratings of perceived sleep quality (on a 1–5 and 1–10 Likert scale), and an estimate of sleep duration were recorded daily. Agreement between sleep estimated via activity monitors and self-perceived sleep was examined using mean bias, Pearson correlation (r) and typical error of the estimate (TEE). 641 nights of sleep were recorded, with a very large, positive correlation observed between sleep duration estimated via activity monitors and subjective sleep duration (r = 0.85), and a TEE of 48 minutes. Mean bias revealed subjective sleep duration overestimated sleep by an average of 19.8 minutes. The relationship between sleep efficiency estimated via activity monitors and self-perceived sleep quality on a 1–5 (r = 0.22) and 1–10 Likert scale (r = 0.28) was limited. The outcomes of this investigation support the use of subjective measures to monitor sleep duration in rugby league athletes when objective means are unavailable. However, practitioners should be aware of the tendency of athletes to overestimate sleep duration.  相似文献   

烟草源茄尼醇的生物分离制备及转化应用进展     

金凌  柳华贵  钟卫鸿 《科技通报》2007,23(4):492-497,507

茄尼醇是存在于茄科植物中的一种萜类物质，尤以烟草中的含量最高，是重要的药物中间体。本文综述了茄尼醇的分布和工业化生产现状，烟草来源茄尼醇的生物分离制备技术，烟草细胞培养生产茄尼醇及其代谢途径和茄尼醇下游产品的转化应用研究进展。  相似文献   

基于EPG的蒙古语塞音、塞擦音研究     

呼和 《内蒙古大学学报(人文社会科学版)》2005,37(3):17-24

塞音、塞擦音的生理长度远远长于其声学长度。在总长度方面虽然没有明显的差别，但不送气音一般都比相应的送气音长。词首塞音和塞擦音都比相应的词尾塞音和塞擦音长。塞音和塞擦音在长度排列方面所存在的共性，可能代表它们的长度特点，而它们的因人而异的长度排列，可能显示了发音人的个性。从词首[t^h]／[t]和[t∫^h]／[t∫]的标志性舌腭接触面积变化图中可以看出，[t^h]／[t]辅音的舌位主要分布在齿区内，是舌尖上齿辅音。而[t∫^h]／[t∫]辅音的舌位主要分布在齿龈区内，是舌尖齿龈辅音。  相似文献