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1.
BackgroundAbusive head trauma (AHT) is a preventable form of child abuse.ObjectiveThis project used a mixed method design to assess the feasibility of the Calm Baby Gently educational baby book intervention for promoting safe practices related to infant crying in an effort to prevent AHT.Participants and settingThree pediatric practices participated between June 2016 and January 2018, including 1045 caregivers who attended their infant’s 2-month well-child visit.MethodsPediatric providers gave the educational baby book to caregivers at the 1-month well-child visit. Caregivers completed a survey at the 2-month well-child visit on their use and satisfaction with the book and responses to infant crying. Thematic analysis of qualitative feedback was performed. Responses to infant crying were compared quantitatively between caregivers who had and had not read the book.ResultsOf the 819 caregivers (78%) who received the book, 92% (754) read it, and 51% (421) had another caregiver read it. Caregivers considered the book approachable, understandable, validating, and helpful for improving knowledge and skills related to infant crying. The book was rated more helpful by caregivers of younger age, male gender, and non-white race. Controlling for age, gender, and race, caregivers who read the book were more confident (p = 0.033) and had more knowledge on how to respond appropriately to infant crying (p = 0.019) than caregivers who had not read it.ConclusionsCalm Baby Gently is a feasible and well-received AHT prevention program. Randomized controlled trials are needed to better understand its impact on knowledge, behavior, and AHT rates.  相似文献   
2.
不良生活习惯和伤后康复不佳导致的肌筋膜疼痛综合征已经成为当前影响人们生活质量的因素之一。本文运用文献资料法,梳理肌筋膜疼痛综合征的诱因及外治(非内服药物治疗)手段,探究其干预手段的疗效,由病因入手,研究最佳干预方法。综合研究表明:(1)肌筋膜疼痛综合征病因包括:骨骼肌及筋膜外伤、风寒入侵机体、慢性劳损、局部肌筋膜慢性炎症损伤等;(2)目前对肌筋膜疼痛综合征康复的方法主要以针刺和温和灸为主,本文纳入针刺治疗和温和灸治疗有效率高达89.5%和100%;(3)其发病的常见部位为腰背部及肩颈部,不同部位、不同病因的肌筋膜疼痛综合征应采取不同的治疗方式,复合治疗方法比单一手段干预效果更佳。  相似文献   
3.
摘要:目的:高原因其特殊环境,世居平原运动员初上高原训练时机体会产生一系列应激反应。借助代谢组学技术,从急性应激和慢性适应2个纬度,比较分析高原训练初期运动员代谢功能所发生的改变。方法:以16名优秀赛艇运动员为研究对象,在高原训练前、年度高原冬训的第4天、第14天调整休息后次日晨取肘静脉血5 mL,分离血浆,借助LC-MS平台测量分析各血浆代谢物,以PCA、OPLS-DA比较各时间点代谢谱的变化。高原训练初期的主要训练内容为低强度有氧训练。结果:1)与高原训练前比较,高原第4天和高原第14天发生显著改变的血浆代谢物各有近80种:a)与高原训练前比较,高原训练第4天血浆苯甲酰胺、吲哚-3-乙醛分别升高约35倍、17倍,血浆苯乙胺、苯酚、吲哚等分别升高约4-8倍;b)高原训练第14天与高原训练前相比,血浆苯甲酰胺、吲哚-3-乙醛、苯乙胺、吲哚等显著升高约2-6倍;血浆胆固醇羟化硫酸酯、色氨酸、3-(4-羟基-3-甲氧基苯基)-2-氧丙酸等下降约2-8倍。2)与高原训练前比较,高原训练第4天苯丙氨酸、色氨酸代谢显著加强,同时,苯丙氨酸、酪氨酸、色氨酸、氨酰-tRNA生物合成显著增加,但不饱和脂肪酸的生物合成显著下调;高原第14天,苯丙氨酸、酪氨酸代谢显著加强,同时,苯丙氨酸、酪氨酸、色氨酸、氨酰-tRNA生物合成仍显著增加,不饱和脂肪酸的生物合成显著下调;高原第14天与高原第4天比较,氨酰-tRNA、缬氨酸,亮氨酸、异亮氨酸生物合成显著上调,而不饱和脂肪酸的生物合成显著下调,精氨酸、脯氨酸代谢加强。结论:优秀赛艇运动员高原训练急性应答期,参与中枢神经系统能量代谢调控的苯甲酰胺、吲哚-3-乙醛升高达数十倍,之后升高幅度下降,可能是高原训练初期代谢适应的敏感标志物。中枢神经系统的应激与适应可能在运动员高原训练初期代谢应答中发挥着关键作用。高原训练初期芳香族氨基酸、支链氨基酸代谢较为活跃,不饱和脂肪酸代谢抑制,其确切调节机制尚待深入研究。  相似文献   
4.
肺动脉高压(pulmonary arterial hypertension,PAH)是一类以肺动脉渐进性闭塞导致肺血管阻力逐渐升高继而诱发右心室衰竭的一种恶性肺血管疾病。PAH病理发生、发展的机制包括炎症反应诱发的内质网应激(endoplasmic reticulum stress,ERS),继而促使血管平滑肌细胞过度增殖和迁移;以及线粒体自噬相关蛋白PINK1和Parkin以及LC3的表达增加,使血管平滑肌呈现抗凋亡表型,并伴随有氧氧化功能损伤,无氧酵解依赖性增加等问题。PAH进一步发展会诱发多种并发症,包括低氧血症、肺纤维化以及右心肥大,可直接引起肺动脉压增加,继而增加心脏压力导致心力衰竭,这是病理发展的主要方向。作为可能治疗PAH的手段之一,有氧运动可从调控ERS、线粒体自噬、改善机体代谢3个方面抑制PAH病理进程。研究综述了近年来关于PAH发生、发展的分子机制的研究进展,进一步论述了有氧运动对PAH改善的分子机制。  相似文献   
5.
邵沁雨 《体育科研》2018,(1):17-25,34
通过对2016年白俄罗斯皮划艇协会与国际皮划艇联合会体育仲裁案例的分析,得出研究结论:禁用药物超长的代谢时间不能成为反兴奋剂规则具有溯及力的理由;虽然《世界反兴奋剂条例》第11条的规定因为存在"集体项目"这一前提而没有违反个人责任原则,但该条第12条由于规定得过于简单仍然违反了该原则;国家司法机关刑事诉讼程序中发现的兴奋剂药物证据,在刑事诉讼程序终止而证据未经质证的情况下,不能直接作为兴奋剂违规行为的认定证据。  相似文献   
6.
Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   
7.
This study draws upon data gathered from five parents who have children with Down syndrome (DS), being educated in mainstream settings in England. The parental perspective of practices, both inclusive and otherwise, is explored through a qualitative lens. Findings suggest that early intervention, such as portage, is important. However, access to services varied across authorities. Additionally, some participants highlighted issues around the Education, Health Care Plan and subsequent annual reviews. Overall, this study offers examples of inclusive practice in the areas of supporting language and communication needs, parental partnership and transition between educational phases for children with DS. However, there are inconsistencies across providers and there is a need for more research into these areas in the future.  相似文献   
8.
This study aimed to investigate the effect of contact (C-SSG) and no-contact (NC-SSG) handball small-sided games (SSGs) on motion patterns and physiological responses of elite handball players. Twelve male handball players performed 10 C-SSG and 10 NC-SSG while being monitored through the heart rate (HR) and rate of perceived exertion (RPE) as physiological responses and time-motion activities profile using video-match analysis. Both game conditions resulted in similar HR responses (> 0.05), but the NC-SSG led to a higher RPE scores. The time-motion activity analysis featured NC-SSG with a greater amount of walking (855.6 ± 25.1 vs. 690.6 ± 35.2 m) and backward movements (187.5 ± 12.3 vs. 142.5 ± 8.7 m) combined with fast running (232.3 ± 8.5 vs. 159.7 ± 5.7 m) and sprinting (79.5 ± 4.7 vs. 39.7 ± 3.7 m) activities (< 0.001). Conversely, C-SSG had a higher percentage of jogging and sideway movements associated with greater frequency of jumping (0.87 ± 0.09 vs. 0.31 ± 0.06 nr) and physical contact (1.82 ± 0.55 vs. 0.25 ± 0.03 nr) events (< 0.001). No between-regimen differences were found for the number of throws (= 0.745). In addition, the RPE was significantly correlated with fast running relative distances (= 0.909, < 0.001) and sprinting relative distances (= 0.939, < 0.001). In conclusion, this investigation showed that both C-SSG and NC-SSG in team handball can effectively represent specifically oriented exercises, according to the sport-task and the performance demands.  相似文献   
9.
利用改进的新陈代谢GM(1,1)模型,借助MATLAB对江苏省高技术产业2016—2020年的人才总量进行灰色预测,并与通过模型预测出的广东、浙江省的高技术产业的人才总量进行对比。建模结果表明,改进的新陈代谢GM(1,1)模型的预测精度比常规模型提高了将近50%,也比新陈代谢GM(1,1)模型和背景值优化模型精度高。预测结果表明,"十三五"末江苏省高技术产业人才总量约为2 549 424人,位于广东之后;人才年均增速约为0.5%,位于浙江、广东之后。  相似文献   
10.
The connection between human cognitive development and motor functioning has been systematically examined in many typical and atypical populations; however, only a few studies focus on people with Down syndrome (DS). Twelve adolescents with DS participated and their cognitive control, measured by the Corsi-Block tapping test (e.g., visual working memory), the Auditory Memory span test (e.g., verbal working memory) and the Tower of London test (e.g., cognitive planning), and motor control, measured by the Purdue Pegboard (e.g., fine motor control), were measured in this study. Results indicate that if people with DS have better performance in fine manual dexterity, they will have better performance in cognitive planning and verbal working memory abilities. The co-activation hypothesis of the prefrontal area and the cerebellum may support this positive relationship. Hence, it is suggested people with DS will obtain benefits in cognitive control by participating in further motor intervention.  相似文献   
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