资源型城市绿色创新能力评价指标体系构建     

程鹤 《科技管理研究》2019,(19)

绿色创新是实现资源型城市经济增长、环境保护、社会和谐的有效途径，而构建资源型城市绿色创新能力评价指标体系是对资源型城市绿色创新能力进行评价的重要环节。本文以国内外具有代表性的机构和文献中的绿色创新能力高频指标为基础，根据绿色创新能力的内涵，结合资源型城市发展特点，海选70个数据可观测的指标，通过数据的正态分布检验后，选取非参数统计方法的灰关联系数与spearman分析方法定量筛选指标。既保证了指标之间信息不重复，又能显著影响评价结果，同时避免了现有研究忽略筛选方法使用条件就加以应用的弊端。以10个典型资源型城市2016年指标数据为样本，筛选并构建了包含27个指标的资源型城市绿色创新能力评价指标体系，验证了筛选方法的可行性和有效性。最后提出了相应的政策建议。  相似文献   

Development of a chemically defined medium for Planctopirus limnophila to increase biomass production     

《Electronic Journal of Biotechnology》2021

BackgroundPlanctomycetes is a phylum of biofilm-forming bacteria with numerous biosynthetic gene clusters, offering a promising source of new bioactive secondary metabolites. However, the current generation of chemically defined media achieves only low biomass yields, hindering research on these species. We therefore developed a chemically defined medium for the model organism Planctopirus limnophila to increase biomass production.ResultsWe found that P. limnophila grows best with a 10 mM sodium phosphate buffer. The replacement of complex nitrogen sources with defined amino acid solutions did not inhibit growth. Screening for vitamin requirements revealed that only cyanocobalamin (B12) is needed for growth. We used response surface methodology to optimize the medium, resulting in concentrations of 10 g/L glucose, 34 mL/L Hutner’s basal salts, 23.18 mM KNO₃, 2.318 mM NH₄Cl and 0.02 mg/L cyanocobalamin. The analysis of amino acid consumption allowed us to develop a customized amino acid solution lacking six of the amino acids present in Aminoplasmal 10%. Fed-batch cultivation in a bioreactor using the optimized medium achieved a final ΔOD₆₀₀ of 46.8 ± 0.5 after 108 h, corresponding to a cell dry weight of 13.6 ± 0.7 g/L.ConclusionsThe optimized chemically defined medium allowed us to produce larger amounts of biomass more quickly than reported in earlier studies. Further research should focus on triggering P. limnophila biofilm formation to activate the gene clusters responsible for secondary metabolism.How to cite: Kruppa OC, Gerlach D, Fan R, et al. Development of a chemically defined medium for Planctopirus limnophila to increase biomass production. Electron J Biotechnol 2021;54. https://doi.org/10.1016/j.ejbt.2021.09.002.  相似文献   

Examining the predictive validity of behavior screeners across measures and respondents     

Corey Jones  Emily Graybill  Brian Barger  Andrew T. Roach 《Psychology in the schools》2020,57(6):923-936

Through this study we compared different informants and different behavior screening tools that are available to screen for behavioral and emotional risk. We examined screening results from 100 students from a high school with a high achiever's magnet program in the Southeastern United States (school demographics: 71% female and 79% black, non-Hispanic). This school conducted behavior screening using both teacher-report via the Student Risk Screening Scale, Internalizing/Externalizing (SRSS-IE) and student report via the Strengths and Difficulties Questionnaire (SDQ). Nonparametric correlation tests were conducted between the SRSS-IE and SDQ externalizing and internalizing scores. Generalized linear regression models were created based on the data (demographics, internalizing, and externalizing scores on both screening tools) to model the two count outcomes (office discipline referrals [ODRs] and absences). Diagnostic accuracy metrics were generated from the scores on both the SRSS-IE and SDQ with the outcome measures (ODRs and absences). Externalizing scores on both screening tools had statistically significant low correlations. The ODR model contained two predictors: externalizing score on the SRSS-IE and internalizing score on the SDQ, while the absence model contained grade and the externalizing score on the SDQ. The highest accuracy and agreement values were seen between students with elevated risks on both screening measures and ODRs. The results confirmed that teacher and student reporting, as well as different screening tools, will result in some different students being identified. The choice of informant and screening tools should be dependent on the needs and resources of the school.  相似文献   

排名前10的与预防运动和体育活动猝死相关的关键问题          下载免费PDF全文

Rachel K. Katch  Samantha E. Scarneo  William M. Adams  Lawrence E. Armstrong  Luke N. Belval  Julie M. Stamm  Douglas J. Cas  朱为模审校 《体育科研》2018,(2):31-46

参加有组织的体育运动和休闲活动存在发生严重伤病甚至死亡的内在风险。虽然造成体育运动或体育活动中猝死的原因有很多，但运动医学和循证标准治疗方面的进展已使临床医生得以更有效地预防、发现和治疗可能致死的伤患。随着研究与技术不断发展进步，当前的治疗标准正在不断发展以更好地改善患者的治疗效果。本文提出了10个与运动和体育活动中猝死的主要原因及其治疗手段有关的关键问题，未来开展的研究将提高运动员和休闲运动爱好者参与运动的安全度。当前证据表明，如采取正确的预防策略或最佳治疗方案，绝大多数的死亡案例是可以避免的。  相似文献   

Policy and evidence: a critical analysis of the Year 1 Phonics Screening Check in England          下载免费PDF全文

Hans U. Grundin 《Literacy》2018,52(1):39-46

“This paper aims to present a critical analysis of the Year 1 Phonics Screening Check (PSC), with special focus on the relationship between the UK Department for Education's policy‐making and the evidence considered in the process of developing and evaluating the PSC. The reports from the in‐house Standards and Testing Agency and from commissioned external organisations with limited remits have been analysed, with emphasis on how the screening check findings have been used in DfE decision‐making. My conclusion is that the department has overestimated both the validity and the reliability of the check: partly because important sources of measurement error have not been explored, and partly because the available evidence has not been analysed in sufficient depth — or perhaps simply been ignored by the department. The whole phonics screening check seems to be the product of policy‐based evidence, rather than evidence‐based policy‐making. This has, in my view, seriously undermined the value of the PSC as a screening instrument, and one must wonder whether it is ‘fit for purpose’.  相似文献   

An audit of total and free thyroxine measurements in screening for hypo and hyperthyroidism in patients using chemiluminescence immunoassay     

J. J. Fleming  S. Rajaratnam  M. S. Seshadri  A. S. Kanagasabapathy 《Indian journal of clinical biochemistry : IJCB》2001,16(1):95-100

An audit of 2509 patient specimens analyzed for both total thyroxine (TT4) and free thyroxine (FT4) by the ACS-180 automated chemiluminescence immunoassay analyzer revealed that there were 219 discrepancies (8.7% of the total). A discrepancy was defined as one analyte within its reference range and the other outside. The discrepant results were divided into 4 groups: group A: normal TT4, but decreased FT4, 101 patients (4.0%); group B: increased TT4, normal FT4, 78 patients (3.1%); group C: decreased TT4, normal FT4, 34 patients (1.4%); and group D: normal TT4, increased FT4, 6 patients (0.2%). TSH measurements were available, by a 3^rd generation chemiluminescent assay, in 142 of these patients, and were consistent with the FT4 result in 72 patients, with TT4 in 61 cases and with neither in 9 patients. The clinical diagnosis was investigated in a subgroup of 43 endocrine patients. Thirteen of the 20 endocrine patients in group A were diagnosed as hypothyroid, with a measured serum TSH, in 11 of them, of median 14.6, range 1.2 to 46.2 μlU/ml. Eleven of the 19 endocrine patients in group B were on thyroid replacement, with a measured serum TSH, in 7 of them of <0.01 μlU/ml. The audit of current laboratory practice led to a suggestion to replace the current thyroid function screening strategy of measuring both TT4 and FT4 by the combination of FT4 and TSH. The reasons for the discrepancies and the alternative strategies for screening of thyroid function are discussed.  相似文献   

高通量药物筛选中靶分子固定化数学物理模型的建立     

李松军  刘白玲 《中国科学院研究生院学报》2005,22(2):179-186

通过对高能量药物筛选基本过程的分析 ,探索了靶分子固定化可能对筛选质量构成的影响 .从分子相互作用看 ,实际的过程远较理想的情况复杂 .分子间存在的静电力、疏水作用力及氢键力能对固定化的机理构成较大影响 ,甚至可能诱发多层吸附的固定化模式 .基于固定化过程中可能存在的靶分子与靶分子、靶分子与微球、体相与表面相之间的相互作用 ,构筑了相应的数学物理模型 ,为实际的筛选工作提供了可参考的理论依据 .  相似文献   

College/University Counseling Centers Supporting Study Away: Challenges and Opportunities     

Charles C. Morse  Janet Dee Spoltore  Paul Galvinhill 《Journal of College Student Psychotherapy》2017,31(4):325-335

Research points to significant numbers of students on college campuses experiencing mental health distress and an ever increasing number of college students who are choosing to make an off-campus educational experience a part of their college careers. When we consider both of these trends together, it is quite apparent that a significant number of students with mental health concerns will spend periods of time studying away from campus, with converging concerns among college mental health and study away professionals about how to best support these students. This article seeks to outline both challenges and opportunities inherent in the collaboration between campus professionals in supporting students with mental health issues before and during their study away experiences.  相似文献   

用西方教育经济理论浅析我国研究生教育改革的必要性     

赵立 《河南职业技术师范学院学报(职业教育版)》2007,(1):90-92

本文运用人力资本理论、筛选理论、劳动力市场划分理论,结合目前研究生教育中出现的主要问题及其原因,分析了研究生教育改革的必要性,并试图提出研究生教育的改革方向。  相似文献   

Developing local oral reading fluency cut scores for predicting high‐stakes test performance          下载免费PDF全文

Sally L. Grapin  John H. Kranzler  Nancy Waldron  Diana Joyce‐Beaulieu  James Algina 《Psychology in the schools》2017,54(9):932-946

This study evaluated the classification accuracy of a second grade oral reading fluency curriculum‐based measure (R‐CBM) in predicting third grade state test performance. It also compared the long‐term classification accuracy of local and publisher‐recommended R‐CBM cut scores. Participants were 266 students who were divided into a calibration sample (n = 170) and two cross‐validation samples (n = 46; n = 50), respectively. Using calibration sample data, local fall, winter, and spring R‐CBM cut scores for predicting students’ state test performance were developed using three methods: discriminant analysis (DA), logistic regression (LR), and receiver operating characteristic curve analysis (ROC). The classification accuracy of local and publisher‐recommended cut scores was evaluated across subsamples. Only DA and ROC produced cut scores that maintained adequate sensitivity (≥.70) across cohorts; however, LR and publisher‐recommended scores had higher levels of specificity and overall correct classification. Implications for developing local cut scores are discussed.  相似文献